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Herpes Simplex Virus Research Paper

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Herpes Simplex Virus(HSV) was identified as a highly attractive candidate for oncolytic virotherapy due to several reasons including the naturally cytolytic life cycle of HSV and the ability to infect a broad range cell type, a highly prevalent human pathogen which in vast majority of cases causes a self-limiting disease that can be treated with antivirals in life threatening cases and so on. The initial focus of oncolytic HSV (oHSV) virotherapy involved demonstrating the safety of oHSVs for the treatment of cancer. Melanoma is the most aggressive type of skin cancer. It accounts for a large proportion of skin-related deaths. Among all cancer types, melanoma has a particularly high propensity to metastasize to the brain, occurring in >50% of all patients with advanced disease. Current therapeutic options of chemotherapy, surgery, and radiation have very limited efficacy for patients with melanoma brain metastasis. These patients either have multiple metastatic lesions or diagonistically challenging asymptomatic lesions, making surgery an inadequate therapeutic option by itself. …show more content…

To model the progression of metastasis seen in patients and to overcome the hurdles of systemic delivery of OV, here, melanoma brain metastasis model was developed in immunocompromised and immunocompetent mice and then the fate and the efficacy of oncolytic herpes simplex virus(oHSV) armed mesenchymal stem cells (MSCs) were

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