For instance, one theory about how mutations affect ageing is the somatic mutation theory. The somatic mutation theory indicates that a vital part of ageing is determined by the consequences of our genes after it has been inherited. Its ideology refers that when mutations occur in somatic cells (all body cells except reproductive cells), it would lead to a substantial functional failure of them, which results in a decreased efficiency of organs and eventually death. One other theory is the mutation accumulation theory which was proposed by Sir Peter Medawar in 1952. He had suggested that in later life, when mutations accumulate, they cannot be selected against in view of the fact that these genes would have already been passed onto the offspring,
There are various genetic changes that people can experience the ill effects of that will presumably never be finished unless we effectively mediate and genetic engineering the cutting edge to withstand these issues. Case in point, Cystic Fibrosis, a dynamic and risky sickness for which there is no known cure, could be totally cured and annihilated with the assistance of particular genetic engineering, so it can almost never aging effect humans.
According to the text, __________ refers to biochemical or genetic changes that cause cell mutations and that account for predictable for age-related diseases.
2. The MSNBC webcast recounts different stories of the aging population in America. One of the cases mentioned in the web cast is Arden peters and his wife Maxine. The aging theory of wear and tear can be applied to the case of Arden peters who has lost his wife Maxine due to dementia and Parkinson’s. He himself became too weak to care for himself due to the process of aging (MSNBC, n.d). He reached a point where he required someone to care for him. His friend Warren DeWitt is taking care of him and previously helped him take care of his wife until she passed away (MSNBC, n.d). The theory of wear and tear is based on the notion that aging is caused by damages done at the cellular level over time (Hawkley, Berntson, Engeland, Marucha, 2005). The processes that could damage the cells could be sickness, radiation, and accumulation of toxic materials over time
To illustrate, the theory of evolution by natural selection is the process by which organisms change over time as a result of changes in heritable physical or behavioral traits. Darwin was the first to formulate the theory and alludes to the fact that given enough time and enough accumulated changes, natural selection can create an
The mutation accumulation theory was proposed by Peter Medawar in 1952. It stated that harmful mutations expressed at a younger age are selected against by natural selection to maximize the fitness of an individual. Deleterious mutations expressed at an older age are not affected by natural selection because the genes are already passed onto the next generation (Hughes 424). Over the next generations, the late-acting deleterious genes accumulate resulting in degradation of biological processes. The mutation accumulation theory and the antagonist pleiotropy theory are similar to a certain extent and can occur at the same time. However, an important difference is that harmful genes at old age accumulate from previous generations in the mutation accumulation theory while
A theory of ageing is a explanation or reason for the natural cause of ageing. It explains the changes a person goes through when they age. Theories can be proved or sided by laws and facts and tested hypotheses.
With the various developments in progress in the biological sciences , particularly genetics then subsequently enriched Darwin 's Theory of Evolution . Natural selection no longer be the sole causative agent of evolution , but there are additional factors other causes , namely : mutation , gene flow , and genetic drift . Therefore the theory of evolution that we now called the Neo - Darwinian seirng or Modern Systhesis .
The change brought about by a mutation is either beneficial, harmful or neutral. If the change is harmful, and then it is unlikely that the offspring will survive to reproduce, so the mutation dies out and goes nowhere. If the change is beneficial, then it is likely that the offspring will do better than other offspring and so will reproduce more. Through reproduction, the beneficial mutation spreads. The process of culling bad mutations
The relationship between infertility and lifespan is unique because it serves as a juncture of the fields of evolutionary biology and epidemiology. As such, relevant theories regarding the bond between fertility and longevity define their models in an evolutionary context, and depend on studies that examine population demographics to support them. Given that these theories are evolutionary in their perspective, they usually gravitate around the trade-off or “compromise” dogma widely accepted within the field of evolutionary biology. One such example is the Antagonistic Pleiotropy Theory of Aging developed by George Williams in 1957. Antagonistic pleiotropy
Two environmental factors that increase the mutation rate in an organism are: viruses and radiation. Viruses insert their DNA into the host’s cells, which disrupts the gene sequence. Radiation is another environmental factor that increases the mutation rate in an organism and its effect is that it damages the
To deduce if UV Radiation induced a mutation in the DNA of Serratia Marcescens and prevented the production of the red pigment called Prodigiosin.
DNA is stable molecule and its replication is done with highest fidelity. However, there are instances in which an error happens and may cause catastrophic effect to the organisms. There are errors or mutations that cause diseases or disorders. Among the vast list of diseases or disorders, I have chosen to look into the rare form of juvenile amyotrophic lateral sclerosis, known as ALS4. The purposes of this paper are to determine the gene mutation and how it causes the disease.
Aging is the process of becoming older, as we age, multiple mutations occur that concern all the processes of aging well as it compromising a number of different genes. There are many theories of biological aging, such as the Cellular Aging Theory, Immunological Theory, and the Wear and Tear Theory. The Cellular Aging theory describes the process of aging in which cells slow their number of replication, thus giving each species a “biological clock that determines its maximum life span” and how quickly one 's health will deteriorate(Hooyman, 42). After a certain number of years, each cell which follows an apparent biological clock starts to replicate itself less, thus the specific individual or species slowly deteriorates. This theory gives
Caenorhabditis elegans (C. elegans) are transparent roundworm, that range about 1mm in length and lack a respiratory and circulatory system. C. elegans is a model organism in genetics, its short life cycle, ease of cultivation, small size, and high cell number and development makes it an easy animal to use in experiments (International Journal of Molecular Science). In this experiment, two strains of worms will be used. Virgin hermaphrodite and him-8 males, which will be the wildtype. Him-8 strain is being use in this experiment because this gene has an increased rate of X-chromosomes, giving a forty percent change of producing male and sixty percent chance of hermaphrodite. This will help produce wildtype and mutant genes in the genetic offspring of the two. Hermaphrodites can be distinguishing from the male counterpart because they have wispy threadlike structure for their tail, whereas male have a blunt-end tail. (C. elegans as a genetic organism) The tails are a great way in telling the difference between these two mutant strain. When crossing these two strain together, the hypothesis that was made would be that we would find more male mutation of an offspring because the male strain is a more recessive gene trait. Dumpy A with a phenotype of dyp-10, this affects body shape and movement, causing the worm to be half of the normal length but the same width, which causes a stumpy effect.
The theories on aging can broadly be classified as programmed and damage based. While the former argues that the complex process of aging is primarily pre-programmed by genes and not due to any random or