Huntington Disease Research Paper

Huntington’s Disease is a brain disorder affecting movement, cognition, and emotions (Schoenstadt). It is a genetic disorder generally affecting people in their middle 30s and 40s (Sheth). Worldwide, Huntington’s disease (affects between 3-7 per 100,000 people of European ancestry (Schoenstadt). In the United States alone, 1 in every 30,000 people has Huntington’s disease (Genetic Learning Center). Huntington’s Disease is a multi-faceted disease, with a complex inheritance pattern and a wide range of symptoms. There is also much research being done in the field of Huntington’s disease, because as of 2012, this disease is untreatable. THESIS.

Huntington's disease is an inherited neurodegenerative disorder. It is passed on to children from one or both parents (though two parents with Huntington's is extraordinarily rare) in an autosomal dominant manner. This is different from autosomal recessive disorder, which requires two altered genes (one from each parent) to inherit the disorder.

It is said that Huntington's disease was first introduced to Australia by a Somerset woman who arrived in Tasmania aboard the "Arab" ship in 1842. She had thirteen children; eight with her first husband and five with her second. Five of the six females and four of the seven males inherited the disease.

At present, there is no cure for the disease, but dynamic progress has been made as researchers explore this illness. HD is inherited as an autosomal dominant condition. In March 1993, scientists realized that HD is caused by a mutation in a gene located on chromosome 4. This gene has a unique genetic sequence for CAG (cytosine-adenine-guanine) and codes for the amino acid glutamine, a building block for the huntingtin pr otein. Normal individuals have this sequence duplicated from 11 to 40 times in their genetic coding without having symptoms of HD. However, individuals with the disease have from 40 up to 100 repeated CAG segments. Juvenile Huntington's Disease occurs wit h 60 or more repeats, linking the longer chains of CAG sequences to earlier and more aggressive onset of the disease.

4. “Huntington Disease - Genetics Home Reference.” U.S. National Library of Medicine, National Institutes of Health, ghr.nlm.nih.gov/condition/huntington-disease.

Huntington's Disease (HD) is a disability that will continue to get worse and worse over time. The lifespan for someone living with HD is 10 to 25 years after they are diagnosed and showing symptoms, which is usually around the ages of 30 to 50 ("What Is Huntington's Disease," 2017). These symptoms begin at different times and depend on the individual. Overtime, the person affected will begin to lose their ability to walk, talk, and eat over the course of these 10 to 25 years resulting in the need for 24 hour care.

Two Diseases, One Hope: Fetal Neural Transplantation in the Treatment of Parkinson's and Huntington's Disease

The disease that I have chosen is Huntington’s disease. Australian Huntingtin’s Disease Association (NSW) says that five in one hundred thousand people have Huntington’s disease. Huntington’s disease is rare in people who descended from Europe, but according to the U.S national library of medicine it is less common in people of “Japanese, Chinese and African decent” to name a few (2017). The symptoms may include: subtle changes in personality and physical skill. The most recognisable symptom is random sporadic movements throughout the body. This is called chorea; this can reduce coordination and cause other minor motor abnormities. This would lead to difficulty chewing, swallowing, speaking, cause unusual facial expressions

Huntington's disease is an autosomal dominant disorder, which is found on the # 4 chromosome. George Huntington discovered it in 1872. It mainly has an effect on the nervous system. There are around 210,000 bases between D4S180 and D4S127. The disease itself is found in 2% of people in their childhood, and in 5% of the people they were older then 60. (Miller p 16) In the majority of the affected people the disease is detected between the ages of 35-45. In males the disease begins around the time of their childhood. However, in females it begins later in life. This severe symptom has a tendency for the condition to worsen as it is passed on from generation to generation. Huntington’s disease is paternally

HD affects men just as much as it affects women. HD is a genetic disease that affects a gene on the 4th chromosome. The defective gene codes the blueprint for a protein called huntingtin. This protein 's normal function isn 't yet known, but it 's called "huntingting" because scientists identified its defective form as the cause of Huntington 's disease. Everyone has two copies of the HD gene. Part of the gene is a repeated section that is called trincleotide repeat. The code for HD is HTT. A trincleotide repeat is defined ad “a class of clinically heterogeneous disorders defined by the presence of an abnormal and unstable expansion of DNA, triplet repeats in the

Huntington 's Chorea or Huntington 's Disease is a rare progressive genetic disorder which afflicts roughly 7 out of every 100,000 people in North America (Rawlins, 2016, pp. 144–153). The disease manifests primarily in tissues of the brain, and affects the shutdown of many primary functions including speech, movement, and cognitive abilities. With a strong genetic component, there is a 50% chance of just one parent passing the gene linked with Huntington 's Disease along to offspring; additionally, studies have proven that everyone with the defective gene will eventually develop Huntington 's Disease. Though medications are used to mange some symptoms of the disease, there is no cure, and there are currently no medication options to manage the psychological and physical decline which comes with end-stage Huntington 's Disease.

3). In this gene, there is an expansion of CAG, or cytosine-adenine-guanine, which gives rise to an abnormal protein that modifies and damages cells in the brain (Roos, 2010, p. 1). The gene for the disease is dominant, which means that children of those with Huntington’s Disease have a 50% risk of acquiring the disease, with no regard to sex of the individual. This disease was probably discovered by Charles Waters, but named after George Huntington, who provided a better description, in 1872 (Roos, 2010, p.

Huntington’s disease, also known as Huntington’s chorea, is a rare pathology among the nervous system. With fewer than 200,000 US cases per year is an inherited condition in which nerve cells in the brain break down over a period of time. This disease will usually start to effect people when they are in their 30s or 40s. Huntington’s usually results in psychiatric symptoms, progressive movement and thinking. No cure to this disease exists but physical therapy, drugs, and talk therapy can help manage symptoms.

What is huntington's Disease? How can I get it? Should I be tested? Is there a cure? These are all really good questions a lot of people would ask about Huntington's Disease. Huntingtons Disease is a brain disorder in which you get from genetics. This means you can only get this disease if somone in your family has had it. Usually you start seeing the symptoms from the ages of 30-50. Huntington's Disease is deadly. I am 30 years old and my father had this disease. Should I get tested for it?

HD is a rare, progressive neurodegenerative disease which usually manifests itself between 30 and 45 years of age . It's characterised by a loss of motor control, jerky movements, psychiatric symptoms, dementia, altered personality and a decline in cognitive function. As the disease is adult onset, many people have already had children before they are diagnosed and have passed the mutant gene onto the next generation. In 1983, a genetic marker linked to HD was found on Chromosome 4, making it the first genetic disease to be mapped using DNA polymorphisms. However, the gene was not finally isolated until 1993