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Hyphal Development: Fumagillin Analysis

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Other toxins Another important toxin produced by Aspergillus fumigatus during hyphal development is Fumagillin having a molecular weight of 458.6 Da (Fallon 2011) Fumagillin suppresses the generation of ROS thereby preventing the immune response, neutrophil function, angiogenesis through a covalent interaction with methionine aminopeptidase-2 (MetAP-2) thereby facilitating hyphal growth. (Fallon et al., 2011) Apart from these A.fumigatus produces various toxic metabolites like Verruculogen, Pseurotin, Sulochrin, asterric acid, trypacidin, fumiquinazolins. Verruculogen is a potent tremorgen and is capable of modifying the electrophysical properties of the human nasal epithelial cells. Pseurotin A inhibits immunoglobulin E function

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