Influenza Infection Study

Decent Essays
In this article, Sun & Metzger (2014) propose the mechanism for influenza- induced predisposition to methicillin- resistant Staphylococcus aureus superinfection. They hypothesize that suppression of NADPH oxidase, an enzyme responsible for the production of intracellular reactive oxygen species during phagocytic bacterial killing plays a pivotal role to enhance susceptibility to secondary MRSA infection. They conduct a mouse model influenza infection experiment followed by S. aureus respiratory challenge to demonstrate impairment of innate antibacterial defense by influenza virus. They find high bacterial burden on influenza and MRSA- coinfected mice as compared to MRSA alone, which infer decreased bacterial clearance capability and survival
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