The influenza virus and Streptococcus pneumoniae are two of the most common pathogens to affect humans; both generally pose no major concern to human life but have the potential to cause catastrophic damage to the lives of susceptible individuals. With many strains of the influenza virus being a constant presence around the world, and S. pneumoniae being a normally harmless commensal bacterium residing in the nasal cavities and upper respiratory tract of healthy individuals , it is likely impossible to quell the spread of either pathogen and so treatments must be found to ensure those with detrimental risk factors are either protected or receive sufficient medical attention in a timely manner in order to prevent irrevocable damage.
Influenza
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There are two important proteins used in the determination of the type of influenza; haemagglutinin (HA) and neuraminidase (NA). There are 18 known variations of the haemagglutinin protein and 11 of the neuraminidase protein, giving hundreds of possible variations in the subtypes of the virus . These subtypes are further divided into different strains that have a divergent molecular makeup, giving rise to viruses that differ in virulence, ease of transmission and severity of symptoms. Not all strains of influenza can cause disease in humans; influenza D subtypes cannot infect humans and influenza C infections are rare and usually very minor. Influenza A and B are the subtypes that are responsible for the common infections and the epidemics and pandemics that occur periodically, with influenza A causing the majority of these infections. The virus is transmitted through the inhalation of droplets which are expelled when an infected person coughs or sneezes, through contact with a contaminated surface and through the exchange of saliva . The infected person becomes infectious to others around 12 hours after first contact with the virus and remains contagious for around the next five days; this can vary as the immunocompromised can take longer to subdue the virus and children tend to be more infectious than adults . The virus incubates in the respiratory tract by invading cells through the cleavage of the viral protein haemagglutinin by human proteases . The pathogenicity of a certain strain is determined by the spread of proteases in the respiratory tract that can cleave the proteins of the virus; a strain is typically milder if the proteases that reside in the lungs and throat are the only ones capable of cleaving the virus, causing an upper respiratory tract (URT)
According to Center for Disease Control (CDC), influenza viruses are divided into three types, designated as A, B, and C. Influenza type C usually only causes either very mild symptoms or no symptoms at all. Types A and B, however, are responsible for epidemics of respiratory illnesses that can result in hospitalization, or even death. Influenza is constantly changing over time by mutations. This continual change allows the virus to evade the antibodies that were meant to kill it. A host infected with influenza virus develops antibodies against that virus; as the virus changes, the "first" antibody no longer recognizes the "newer" virus and infection can occur because the host does not recognize the new flu virus as a problem until the infection is well under way. The first antibody developed may, in some instances, provide partial protection against infection with a new influenza virus. According to Medicine Net.com, In 2009, almost all individuals had no antibodies that could recognize the novel H1N1 virus immediately. It quickly spread throughout the world so fast that the WHO declared this new flu strain (termed novel H1N1 influenza A swine flu). There are currently four main strains of influenza circulating worldwide. Three of the viruses are type A, and one is type B. Type A viruses are divided into subtypes based on the differences in two viral proteins called hemagglutinin (H) and neuraminidase (N). The three subtypes of influenza A are A(H1N1), A(H3N2), and A(H5N1). The reason for several strands of type A are because of the two kinds of change influenza A
Every year, millions of people start talking about the influenza virus and getting their vaccines as the flu season approaches, which starts around the October-November period and reaches its peak between December and March. Therefore, public health officials around the world- and in the U.S in particular- are constantly challenged by properly preparing for the annual influenza dilemma, given that this viruses, and other respiratory viruses, are a serious health threat to the U.S population and the world as a whole. Furthermore, what makes the influenza virus even more challenging to control is that it can mutate rapidly and reassort to form new strains, having the ability to reside in multiple animal hosts. In fact, many scientists and researchers have been doing in-depth intensive research so as to understand the mechanism behind this unique characteristic of the virus, try to find new ways to control it, and explore different areas of protection and vaccination.
Influenza, also known as the flu, is a contagious respiratory illness caused by the influenza virus that infects the nose, throat, and lungs (Centers for Disease Control and Prevention,
According to the CDC there was a breakout in “1918-19 Flu pandemic, which killed as many as 50 million people worldwide”causing the biggest breakout for Influenza (Reconstruction of 1918 Influenza Pandemic Virus). Influenza originated from Asia and the Middle East. Virtually all mammalian species have influenza. Influenza is a contagious respiratory illness caused by the Influenza virus. There are three types of Influenza: type A, type B, and type C. Influenza has numerous symptoms, vaccinations, and is unlikely to kill it’s host.
According to the Centers for Disease Control and Prevention (CDC, 2013) national healthcare disparities report for 2010, influenza and pneumonia are ranked within the top ten major causes of death in the United States. The influenza viruses that will be discussed throughout this case study include the human influenza viruses: A and B. These viruses are responsible for seasonal epidemics during the fall and winter around the globe in temperate environments. Historically influenza outbreaks have had a seasonal distribution and characteristic time course although according to the CDC (2017) factors influencing the extent and severity of an outbreak are less clear. Generally, there are two or three different influenza strains typically circulating concurrently in any given
Paula Sullivan, a seasoned nurse practitioner, discusses how influenza is an infectious disease that takes place “in temperate regions around the world” which results in approximately the death of 500,000 people “annually” worldwide; 226,000 people get hospitalized and 36,000 die from influenza annually in the United States alone (Sullivan). Most of the people who die from the influenza virus are aged 65 years or older and that is usually because other diseases are
Influenza is a highly contagious viral infection of the respiratory passages that causes severe body aches, high fever, and can sometimes lead to death. To be protected, you must be immunized every year. “A new study found that the influenza vaccine prevents type A and type B in only 1.5 out of every 100 vaccinated adults, but the media portrays these statistics as this meaning the vaccination is 60 percent effective” (Medline Plus). Unfortunately, this does not mean 60 out of 100 people who receive the flu shot leads to protection against influenza. Researchers can confirm that most strains of influenza are harmless against healthy individuals; however, the virus has an ability to mutate into different strains which can cause an extensive
Once there was a virus named Birdie. This virus was a Bird Flu, or Avian Influenza, virus of the subtype H5N1, the first strain of Avian Influenza having the ability to infect humans (Normandin and Solan). Birdie looked like a microscopic pomander, a fragrant orange with cloves stuck in it. Inside, she had eight pieces of single stranded ribonucleic acid or ssRNA. Birdie was deadly to humans, but was not able to spread from one human to another. She could only spread from birds to humans ("Bird Flu"). Birdie started out inside a chicken named Cluck, where she was formed. A little while later, Cluck's farmer Mark, sold his Cluck, to Joe, another poultry farmer because Mark did not realize that Cluck had H5N1. After a few months of Cluck living
Usually, Influenza can be treated, and the majority of people who are infected can be cured, but in some cases it can cause the death of some people. Pregnant women and oboe patients are very likely to die if they get infected by influenza. Furthermore, the chance of death increases in patients whose ages are less than 5 years (especially children of age two years), and in adults whose ages are older than 65 years. Chance of death also increase in immune compromised patient, and people who suffer from chronic diseases (2). Sometimes, these patients need to be admitted in the hospital
According to Healthy People 2020 a goal of theirs is to “increase immunization rates and reduce preventable infections.” The influenza virus is one of these preventable infections, which can cause serious harm to patients. The influenza virus is known as the “flu.” Everyone in his or her life has had some experience with the flu, whether that is himself or herself or a family member. What if there was a way to ensure people from contracting a strain of the influenza virus? Well, thanks to technology and medical research there is.
Influenza is one of the most contagious illnesses caused by airborne viruses. I can lead to mild or severe illness and even death. Influenza can come suddenly and is marginally different to a ‘Cold”. The virus can cause infections of the lower respiratory tract (lungs) and the upper respiratory tract (throat, nasal). Influenza is disease that may cause symptom such as the following; fever (high body temperature), sore throat, muscle or body aches, cough, Headaches, runny or stuffy nose, fatigue/tiredness (CDC, 2016). it belongs to “Orthomyxoviridae” family of infections, “myxa” meaning ‘mucus’ in Greek. There are three major types of influenza that may also be addressed as different terminologies, such as flu
Influenza (also known as the flu) is a contagious respiratory illness caused by influenza viruses. It can cause mild to severe illness, and at times can lead to death. The best way to prevent the flu is by getting a flu vaccination each year.
Avian influenza results from infection by viruses belonging to the species influenza A virus, genus influenza virus A and family Orthomyxoviridae. These viruses are also called type A influenza viruses. Influenza A viruses are further classified into subtypes based on two surface proteins, the hemagglutinin (HA) and neuraminidase (NA) (Tong et al, 2013). The viruses are roughly spherical (120 nM) with glycoprotein spikes on the surface and genome consisting of also eight RNA fragments that encode 10 proteins. The haemagglutinin (HA), neuraminidase (NA) and matrix (M2) proteins are embedded in the envelope lipid bilayer derived from the host cell (Lamb and Krug, 2001) (figure1). The M1 protein underlying the envelope is the major determinant
Background & Audience Relevance: Influenza is an infection that can affect anyone around the world. Am quite sure almost everyone, if not all of us, have been infected with influenza at some point in our lives.
With a huge number of victims, 80 to 100 million, since 1918, the influenza is considered as one of the most pandemic diseases ever. There are three types of influenza virus: influenza virus A, influenza virus B, and influenza virus c. These are a subtypes of the virus family orthomyx-oviride. The types B and C do not cause pandemic diseases while type A does. The type A classified into three main subtype H1.N1, H1.N2, and H3.N2. The (H.N) refers to the two kinds of proteins on the surface of the virus (hemagglutinin and neuraminidase). The difference in numbers is due to the difference in protein variability. A H1.N1 virus which is widely known as Spanish flu is the only type that can transmit from human to human. The H5.N1, or “bird flu”