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Investigation Of Heat Transfer During Hyperthermia

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Proceedings of Heat Transfer
MAE 589
Spring 2015, Tempe, Arizona, USA
MAE589-00001

ANALYSIS OF HEAT TRANSFER DURING HYPERTHERMIA

Syed Hussaini
Arizona State University
Department of Mechanical and Aerospace Engineering
Tempe, AZ, USA Pratik Sankhe
Arizona State University
Department of Mechanical and Aerospace Engineering
Tempe, AZ, USA

Abstract
Hyperthermia is a cancer treatment wherein the cancerous cells are killed by electromagnetic heating of malignant tumor tissue. This study is focused on the effect of using a 432 MHz antenna heating source for hyperthermia treatment of tissue. Temperatures of 42 °C to 46 °C are required to kill the cancer cells while the healthy tissue is unaffected. The Pennes Bio-Heat Equation is used to obtain a numerical solution of the tissue temperature profile. A 1-D analytical solution required to make quick calculation is derived and compared with the 2-D numerical solution solved by Finite Difference Method (FDM). Also, the effect of variable tissue properties in the tissue region of tumor and healthy tissue is determined and the effect of a large blood vessel is also determined.

INTRODUCTION
Cancer is a malignant disease that can cause death if not treated on time. Hyperthermia is a treatment in which Electromagnetic (EM) waves are used to heat up the tissue containing the tumor for therapeutic purposes. The cancerous cells are killed if they are heated in the range of 42 °C to 46 °C for an established period of time which is

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