:
This was cross sectional non- matched case-control, hospital based study
Discussion: Longitudinal growth assessment is essential in child care especially in those who complain of chronic illness like epilepsy. that because the disease may affect growth parameters directly or indirectly through the long term use of AEDs. In this study we found that the majority of epileptic children either using valporate mono therapy (57.7%) or valporate with other drug (7%). while carbamazepine was used in (25.4%) as monotherapy or with other drug in (2.8%). More than 50% of the doses were ranged between 10 to 28 mg/kg which is a moderate dose with (60.6%) of the patient's duration ranged between 1 year and 5 year.
…show more content…
Albert P. Educational Underachievement in Children with Epilepsy: A Model to Predict the Effects of Epilepsy on Educational Achievement. J Child Neurol, 2005; 20:175-180.
(8). Hackett R, Iype T. Malnutrition and childhood epilepsy in developing countries. Seizure jour, 2001; 10(8):554-8.
(9). Cabral FR, et al. Malnutrition in infancy as a susceptibility factor for temporal lobe epilepsy in adulthood induced by the pilocarpine experimental model. Dev Neurosci , 2011; 33(6):469-78.
(10).Gonzalez-Reyes RE et al. Manganese and epilepsy: a systematic review of the literature. Brain Res Rev. 2007; 53(2):332-6.
(11). Moreno CB, Gutiérrez-Alvarez AM, González-Reyes RE : Zinc and epilepsy: is there a causal relation between them? . Rev Neurol , 2006; 42(12):754-9.
(12). Bertoli S, Cardinali S, Veggiotti P,et al . Evaluation of nutritional status in children with refractory epilepsy. Nutr J, 2006; 5:14.
(13).Biton V. Effect of antiepileptic drugs on bodyweight: overview and clinical Implications for the treatment of epilepsy. CNS Drugs ,2003; 17:781–91.
(14). Klein KM, , et al .Topiramate, nutrition and weight change: a prospective study. J Neurol Neurosurg Psychiatr, 2008; 79:590–3.
(15). Crepin S et al. Link between epilepsy and malnutrition in a rural area of Benin. Epilepsia, 2007;
Despite the vast research on nutrition and health, malnutrition is still a major fatality in this present day. Policymakers, social scientist and medical experts have expressed alarm about the growing problem. While most agree that the issue deserves attention, consensus dissolves around how to respond and resolve the problem. Malnourishment continues to be a primary health liability in developing nations such as Asia, sub-Saharan Africa and Latin America. It is globally the most significant risk factor for illness and death, predominantly with hundreds of millions of pregnant women
Treatment for epilepsy is often focused on controlling the seizures with the least amount of medication as possible. Antiepileptic drugs (AEDs) are the class used to accomplish this. Some of the AEDs that are used most often are Clonazepam, Diazepam, Divalproex, Gabapentin, and Phenytoin. The most common side effects of these medications include nausea, vomiting, sedation, fatigue, and lethargy. (Kwan,1; Benbadis, 3-5; Huethers,637)
Standard measurements- the child’s height and weight could be tested to see if they are growing at the speed of their age. If the child is smaller than they should be that could be because they have a disability or from the characteristics of their parents.
References Shashidhar, H. (2016, March 10). Malnutrition. Retrieved September 27, 2016, from
The ketogenic diet; one of the oldest treatments for epilepsy is based on the creation of ketones in the body. The creation of ketone bodies is accomplished through high fat intake, carbohydrate depletion and a fasting-metabolism; over long periods of time. When the body is in a fasting state, it creates ketones, a by-product of a fat-burning metabolism. It has long been recognized that seizures often lessen or disappear during periods of fasting in some individuals with epilepsy (Richard Senelick, 2014). This fat-burning metabolism is slowly become popular amongst dieters and endurance athletes. Besides the clear loss of body fat there is the increase in brain processes that create extreme amounts of clarity.
The purpose of this study was to find another alternative medication to be used in managing status epilepticus in a hospital setting. This study compared intravenous (IV) valproate and diazepam infusion in patients with status epilepticus (SE). The main goal of this study was to evaluate the efficacy and safety of IV valproate and continuous diazepam infusion as second-line anticonvulsants. Side effects were also evaluated in this study. The major goal from this study was to maintain and terminate the status epilepticus
Rascati KL; Richards KM; Johnsrud MT; Mann TA. (2009). Effects of antiepileptic drug substitutions on epileptic events requiring acute care. pharmacotherapy.
Idiopathic generalized epilepsy (IGE) is a major health concern, constituting up to one third of epilepsies (1). They are determined by genetics and affects people of all sexes and races. Many IGEs are lifelong, and have an onset during childhood or adolescence (1). One drug that is used to treat IGEs is the barbiturate, phenobarbital (2). This medication is one of the oldest available antiepileptics, and is low cost and effective (2). However, there are some serious side effects of the drug which include somnolence, neuralgic pain, hyperactivity, hypotension, respiratory depression and impairment of fine motor skills (3).
Choosing an appropriate antiepileptic drug is the key to successful medical management of epilepsy in children. The choice of antiepileptic drug depends on several factors, of which the most important is accurate seizure classification. The other factors used to choose an appropriate antiepileptic drug include the side effect profile of the drug, The available age- and patient-appropriate preparations of the drug, Whether therapeutic levels are needed quickly or not (depending on the frequency and severity of the patient’s seizures), and the patient’s comorbidities.
Status epilepticus are seizures lasting >20 minutes, or repeated seizures without regaining consciousness [71]. Physicians should be particularly careful with it, since the background may be other than epilepsy. Infection, haemorrhage, trauma, hypoxia, ischemic or haemorrhagic stroke, hypoglycaemia, hyponatremia, drug toxicity and alcohol withdraw should be ruled out. In any of the above, the provoking cause should be treated. If the cause is epilepsy, the treatment of choice is benzodiazepines and the second choice is phenytoin/ fosphenytoin, but with caution as rapid infusion may induce cardiovascular problems. For resistance in those two drugs, the Neurocritical Care Society’s Status Epilepticus Guideline
Myth #3: Only children have Epilepsy, or you have to be born with Epilepsy to have it. Once upon a time people began the belief that children are the only people who can have the disease. False, men, women, and children can have this disease. Epilepsy is not confined to a certain age or gender. People can acquire this disease by heredity, or by a severe head trauma. Adults are not excluded because they may experience tumors, strokes, cysts, or infections sometime in their lives, which would cause post-traumatic Epilepsy. Children on the other hand, were once believed to be the sole carriers of the disease, probably because children can grow out of it. Children who have Epilepsy have one specific treatment options available to them, which is not available for adults. The Ketogenic diet, a diet high in protein and low in carbohydrates has worked to stop
Epilepsy is one of the most complex neurological disorders there are. It occurs mostly in children in many different ways, like through genetics or even because of something as simple as a high fever. Most epilepsies are managed with medications whose effects vary not just from person to person, but also by the type of epilepsy. There are many cases of epilepsy that cannot be managed with medication. Just one medication could take at least two years to find the right dosage and often that patient would have to incorporate an accompanying medication to balance the effects of the fist medication, thus resulting in high toxicology. But in 1921 the Mayo Clinic’s Dr. Wilder suggested that the Ketogenic diet, a diet in high fats and low carbohydrates,
Epilepsy is one of the most common neurodegenerative disorders that affect around 1% of the global population worldwide. Although the optimal use of the 24 approved anti-epileptic drugs in The United States has successfully treat some of the symptoms-related epilepsy, but not the underlying epileptogenesis processes, particularly in neonatal epilepsy. Newborn are more subjected to early-onset of epilepsy because of the common complications of labor in human, such as hypoxia-ischemia and pre-eclampsia. Such complications may cause major damage in the neonates’ brain, including inflammation, neuronal degeneration and other types of damage-related brain injuries. In recent years, great number of evidence point to inflammation as a potential pathway
An individual can be diagnosed with GLUT1 deficiency using multiple tools to deduce its presence. The primary testing for GLUT1 deficiency is through measurement of glucose and lactate concentration in the cerebrospinal fluid. Low levels of glucose and lactate in the fluid indicate the onset of the disease (Suls et al., 2009). Most of the phenotypic abnormalities can be treated or reduced utilizing a ketogenic diet. Since ketone bodies utilize a different transporter to facilitate the movement of nutrients they can supply the brain with a viable fat-derived source of energy which ultimately can reduce the onset of epilepsy (Leen et al., 2010).
At least 1 million malnourished children die every year because they lack access to the necessary treatment; 17 million children suffer from severe acute malnutrition, a deadly condition if not treated according to Action against Hunger and organization taking steps to alleviate hunger around the world. Not only is malnutrition a current issue presiding in our world it is that of a growing nature and stemming far beyond that of a hunger issue. Inadequate intake of essential vitamins and nutrients has repercussions on the entire body. One of the most concerning aspects of malnutrition on the body is that of its impact on the brain. The brain is singularly in charge of thinking, conducting emotion and producing bodily reactions; with that the