Introduction Major depressive disorder (MDD) is currently labeled one of the world’s greatest health problems, with an estimated prevalence of 4.7% and the second highest cause of years lived with a disability in 2010. The economic impact on patients with MDD is extensive particularly in patients that do not respond to treatment. Severe MDD can lead to loss of productivity and increase mortality. There remain several antidepressant treatments (ADTs) available to patients with MDD, but there is a significant minority that do not respond to first-line treatments. Secondary treatment options, including changing the current ADT or adding another ADT to the treatment regimen, such as a second generation antipsychotic. Currently, aripiprazole and quetiapine are the approved therapies in the United States for unresponsive MDD patients, including the adjunctive usage of fluoxetine and olanzapine. Their efficacy has been proven countless times in randomized controlled trials of these agents, but their tolerability profiles has limited their clinical usage. Side effects fluctuate between medications, but most regularly comprise of akathisia for aripiprazole, increased appetite and weight gain for olanzapine-fluoxetine combination, and excessive sedation for quetiapine. Weight gain can be a particularly menacing side effect as it increases a patient’s overall risk of metabolic abnormalities; extrapyramidal symptoms (EPS) which is equally linked with eventual risk of tardive
Major depressive disorder is a common mental disorder characterized by low mood, decreased mental and motor activity, pessimistic view of everything around, loss of interest in life. It is one of the most common types of depression, in contrast with other type depression, major depression represent complex of symptoms. Major depression is also known as major depressive disorder, clinical depression or unipolar depression. The word unipolar refers to the presence of one "pole" - a range of emotions, which is characterized by only one type mood, without manic episode. According to the WHO about 350 million people is suffered from depression. It damages not only people with depression, also to the relatives and other. Mullarkey et.al. suggest that due to reduced ability to work of depressed workers employers annually loss approximately 30 billions $. Thesis statement_____ Preview_______
Major depressive disorder is one of the most common mental disorders, with a 12-month prevalence of 6.7% of adults in the United States (NIMH). There is no definite etiology of depression, but several risk factors have been identified. Functional and structural changes in the brain have also been explored. The most common treatment for depression is the use of drugs that act on monoamine transmitters, including norepinephrine, dopamine, and serotonin. Decreases in these transmitters, especially serotonin, were hypothesized to play an important role in the cause of depression (Breedlove & Watson, 2013). The serotonin hypothesis led to the development of selective-serotonin reuptake inhibitors (SSRIs), which increase the amount of serotonin in the brain. Further research suggests that the serotonin hypothesis is not entirely accurate and the neurobiology of depression is much more complex. The “chemical imbalance” explanation of depression may not reflect the full range of causes and may be given greater credibility by patients and doctors than is supported by evidence based research.
Major depressive disorder, we all have probably heard of it, but do we really know what is it is ? Major depressive disorder is “a mood disorder that causes a persistent feeling of sadness and loss of interest… major depressive disorder or clinical depression, affects how you feel, think and behave and can lead to a variety of emotional and physical problems”(Mayo Clinic Staff). Having this disorder puts you in a very unstable position because you are constantly feeling depressed so it affects the way you think and feel and that can be very dangerous. Sometimes this happens to a person for one day, but put yourself in the shoes of someone who experiencing this for more than two weeks? When you have major depressive disorder, the signs of depression disorder can last for two weeks or more(myers646). This dis order must be treated immediately because “depression may make you feel as if life isn 't worth living”(Mayo Clinic Staff). Feeling this way can lead you to doing things that you can not take back such as committing suicide and sadly that can happen when you have major depressive disorder. Kiyohara and Yoshimasu conducted a research that showed that 90% of suicides have were dealing with major depressive disorder(qtd. in The World Health Organization). Throughout this paper I will be discussing the causes, symptoms and treatment when dealing with major depressive disorder.
Mental disorder is a common term to refer people’s mental health conditions in Canada and internationally. People who have studied Hamlet, a play that’s written by William Shakespeare, know that Ophelia is one of the characters who suffer from a mental disorder, which known as major depressive disorder. At the beginning of the play, Ophelia’s mental state is very healthy, she falls in love with her boyfriend Hamlet, yet their relationship is controlled by her father. During the play, Ophelia experiences a transformation of her mindset, which causes by Hamlet. As the play closer to the end, the death of Polonius, father of Ophelia, makes Ophelia’s mental becomes more unstable, which leads her to suicide at the end. Thus, due to all the unhappy events that happen to Ophelia’s life all at once, the psychological harms slowly turn Ophelia becomes insane and eventually brings her to death.
d. A nurse gives a PRN dose of an antipsychotic drug to a patient to prevent violent acting out because
In an attempt to better understand depression in today’s youth, I have chosen to explore the depths of Major Depressive Disorder and how it affects the young people in our society. Depression amongst school age children and adolescents are the primary focus. The prevalence, adversities, and treatment of the depression are discussed as well. After exploring these few facets of the disorder, I will talk briefly about the Ecological Model developed by Urie Bronfenbrenner and Morris in 1998 that is used by counselors to help evaluate and assess the children who are referred by teachers or medical
The typical description of a disease would be something that causes unwanted effects on the body; however, mental illnesses show few physical symptoms and cause problems that outsiders can rarely see. Major Depressive Disorder (MDD), to be specific, is a complex disorder that occurs when a person has five of the following symptoms: a depressed mood, diminished pleasure, weight loss or gain, insomnia, lethargy, problems with concentrating, fatigue, feeling worthless, or having thoughts of suicide (Myers 3). While MDD is chronic, depression is the infrequent counterpart. The official etiology of depression is important because it is widespread and is becoming increasingly more common. Knowing why an illness occurs, in theory, can help physicians
Major Depressive Disorder or MDD is a very common clinical condition that affects millions of people every year. According to the Agency for Health Care Policy & Research, “ depression is under diagnosed & untreated by most medical doctors, despite the fact that it can almost always be treated successfully.
Major Depressive Disorder is defined as a “moderate-to-severe mood disorder in which a person experiences only major depressive episodes but no hypomanic, manic, or mixed episodes” (Butcher, Hooley, & Mineka, 2014, p. 618). Major Depressive Disorder (MDD) is also referred to Major Depression. MDD is also “characterized by a combination of symptoms that interfere with a person’s ability to work, sleep, study, eat, and enjoy once-pleasurable activities. Major depression is disabling and prevents a person from functioning normally. Some people may experience only a single episode within their lifetime, but more often a person may have multiple episodes” (National Instittute of Mental Health, 2014, p. 2)
According to the The Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM–5; American Psychiatric Association [APA], 2013); Major Depressive Disorder (MDD) is a medical illness that affects how you feel, think and behave producing persistent feelings of sadness and loss of interest in formerly enjoyed activities. Depression can lead to a variety of emotional and physical problems. It is a chronic illness that is usually characterized by episodes of remission and episodes of relapses. (APA, 2013) Antidepressant medications are effective in treating depression, but not all people with MDD, can attain remission for long periods of time and fewer will completely recover with antidepressants alone. According to Hollon et al. (2014)
Major Depressive Disorder and Major Depressive Episodes affect many across the country in various forms and degrees. Though many are affected by MDD/MDE most do not receive the help they need. A group that may not always be acknowledged in suffering from major depressive disorder/major depressive episodes are adolescents. Consequently, more often than not, adolescents do not receive a diagnosis or support with their struggles. Mental illness symptoms in adolescents may be dismissed for various of reasons, but can have a serious impact on various aspects of their lives.The struggles could be mitigated and managed by a public health approach. Public health approach may help to first collect the information on the extent of the issue. The
Major Depressive Disorder : Major depressive disorder (MDD)is a serious clinical mood disorder that severely impacts a person's everyday life and wellbeing. Catatonic Depression : Catatonia is a state where a person appears unresponsive and moves little, if at all. It is a type of depression that often confuses doctors. Seasonal Affective Disorder : Seasonal affective disorder (SAD) is a type of depression that is common during winter months where exposure to sunlight is minimal. Dysthymia (Chronic Depression) : An estimated 35 million people in the U.S. have suffered from dysthymia at some point in their lives. Atypical Depression : Atypical depression can be difficult to treat as its criteria isn't as easily defined as other types
Major depression disorder (MDD) is a serious mental disorder that has an intense impact on the individuals social and economic mobile functioning, directly related to increased disability, absenteeism from employment, and social exclusion (Haddad & Gunn, 2011). Research suggests that mothers who are depressed have the potential to genetically predispose their children to social, cognitive impaired development; it appears as though offspring may experience heightened susceptibility to experience occurrences of depression and other mental health problems later in development (Haddad & Gunn, 2011). An individual that has MDD may experience feelings of worthlessness, and inappropriate guilt (American Psychiatric Association, 2013). Feelings of hopelessness initiate an distorted view of self, this can be lethal, by way of suicidal ideations or substance misuse. Relevantly, approximately 60 percent of individuals that have committed suicide have had depression, and individuals who are younger in age that commit suicide are more likely to have alcohol use disorder (AUD) or another substance use disorder (SUD) in addition to MDD (Haddad & Gunn, 2011).
Depression is a normal emotional reaction to perceived loss and hopelessness (Segal, Williams, & Teasdale, 2002). There are a number of different types of depression such as chronic depression, manic depression and the primary focus of this essay Major Depressive Disorder (MDD). MDD is a clinical depression, which is more chronic and more severe compared to other types of depression. It significantly disrupts the individual’s ability to meet the normal demands of life. According to many clinicians, clinical depression should be considered as a medical illness in need of medical intervention. Other mental health professionals believe this is an overstatement of the role of physiology and the
Depression is the most common of all psychological disorders, affecting 100 million people worldwide. The depression ranges from mild feelings of uneasiness, sadness, and apathy to intense suicidal despair. (Kasschau) If left untreated, it could lead the