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Map Case Study

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Haloperidol is one of the choice treatments for treating MAP. Haloperidol is also an aggressive dopamine blockade (antagonist) which has been hypothesized to worsen craving and reduces motivation to continue medication and which may lead to a high chance of a drug relapse. Quetiapine targets dopamine D2 and serotonin 5-HT2A receptors and therefore may have fewer side effects that may lead to a lower risk of drug relapse. “The aims of this study were to compare the antipsychotic and adverse events of quetiapine, an atypical antipsychotic drug, to haloperidol, a standard treatment for primary psychotic disorder, in individuals with MAP.” It is hypothesized that overall Quetiapine may be a better option for treating MPA because it may help…show more content…
The study was approved by the local ethical Committee of the Thanyarak Institute and was performed with ethical standards based on the declaration of Helsinki. Patients were randomly assigned into either a quetiapine group consisted of 36 patients or a haloperidol group consisted of 44 patients by block randomization. The quetiapine group had 30 males and six females there mean age was 25.2. All quetiapine group used speed pills and 11 also used ice (crystal meth). There were 13 female and 31 males in the haloperidol group. The mean age was 22.8. All users in this group used speed pills and 15 used iced (crystal meth). The quetiapine group was started at 100 mg per day and the haloperidol group started at 2 mg per day orally, once a day at bedtime. This study lasted 4 weeks. The pharmacist at Thanyarak Institute created identical capsules of quetiapine and haloperidol. They also used block randomization. The treatment was blinded for the patients, investigator, doctors and research nurses. The doses for quetiapine were increased from 100mg to 200mg to 300mg every five days if psychotic symptoms continued. Haloperidol was increased from 2mg to 4mg to 6 mg every five if psychotic symptoms continued. If violent aggression occurred and need to be controlled immediately, 10 mg of diazepam was admitted every 4 hours. “Psychotic symptoms were measured using the Positive and Negative Syndrome Scale (PANSS). The PANSS was scored every day in the first week, then every 2 days
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