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Melanoma Research Paper

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Disease Condition
Melanoma is a malignant condition arising from melanocytes in the basal layer of the skin. Melanocytes are the cells that produce melanin, which gives skin its pigmentation and shields the deeper layers of skin from the damaging effects of ultraviolet radiation. When skin is exposed to ultraviolet radiation, melanocytes increase their production of melanin, which generates darker pigmentation of the skin. Ultraviolet radiation stimulates malignant changes within the melanocytes by mutating DNA, stimulating cutaneous growth factors, decreases immune defenses, and promotes species of melanin that cause DNA impairment and suppress apoptosis. The abnormalities caused by ultraviolet radiation in the melanocytes predispose it to …show more content…

Those who have light skin, hair, and/or eye colors are at an increased risk for developing melanoma over their opposite counterparts. Risks escalate for those who are sensitive to the sun and develop sunburn easily, have a history of intense sunburns, or never tan. A family history of melanoma is another risk factor associated with developing the disease. Persons with a personal history of melanoma are at a greater risk of recurrence. Significant numbers of freckling and moles in an individual is an additional risk factor in developing melanoma. Controllable risk factors include the use of ultraviolet radiation tanning beds, and the time one spends in the sun under natural ultraviolet radiation (Calianno, 2011). Sunburns in later life and cumulative lifetime exposure to ultraviolet radiation are important factors in the development of melanoma, but blistering sunburns in early childhood markedly increase a person’s risk …show more content…

The first is the ABCDE rule. Each letter stands for a sign or symptom to be on the lookout for. “A” is for asymmetry. Melanoma lesions are typically not symmetrical. “B” stands for border. The borders of melanoma are jagged and blurry, usually with no definitive end. “C” represents color. Melanoma varies in color within the lesion and can be tan, brown, black, red, blue, or white. “D” or diameters in melanoma lesions are usually larger than an eraser on a pencil, about 6 mm. “E” corresponds to evolution. Evolution is characterized by any change happening within a lesion, or growth of a satellite lesion (Calianno, 2011). The second rule is the “Ugly Duckling” rule. This rule points of the significance of a lesion that is different than those that immediately surround it, or a lesion that is in an area by itself (Pullen,

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