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Mice And Non-Human Primate Model

Decent Essays

In late 18th century France it was common to lose one’s head due to political strife, but could the number of beheadings increase in the early 21st century by elective choice? One of the most controversial and discussed surgeries for the past century has been the concept of allo-head and body reconstruction, i.e. head transplantation. A major advocate for this surgery, Sergio Canavero, has increased its publicity and made major movements to get this procedure to happen in human subjects in the next decade. A recent article published in The Guardian has illustrated this surgeon’s enthusiasm to perform this procedure at all costs and was even quoted to state that there is nothing left to learn from animal studies (1). Although there is much that can be learned from applying this surgery to humans, we have not exhausted the information that animal studies can give us over this topic. …show more content…

Although the physiology and function is somewhat different in rodents and human spinal cords there are many biological functions that are conserved in vertebrate animals (2). In many spinal cord injuries, rat models are employed to study cell death, inflammation, and regeneration (2). In surgical modeling, recapitulating the physiology is important to insure surgical techniques can be employed across species. Non-human primates contain spinal cords that are more like humans due to closer evolutionary distance (3). Using both model organisms can help to answer questions on the cellular level as well as the macroscopic concept of

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