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Mucosal Oedema Lab Report

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Introduction

Exchange of heat and moisture is one of the primary functions of the respiratory system. The nose has a network of thin walled veins which helps to heat the inspired air thereby increasing the water carrying capacity. Numerous goblet cells present in the pseudo stratified columnar ciliated epithelium and submucosal glands of the upper respiratory mucosa aid humidification of the air. After endotracheal intubation, exposure of respiratory tract to cold and dry air gases (anaesthetic agents / oxygen) damages the epithelium, causes thick and dry secretions, and potentiates bronchospasm (1). Furthermore relative immobility of sedated and ventilated patients lead to atelectasis, weakness and impaired cough which contribute to thickened secretions.

To tackle this ubiquitous problem in our unit, all patients are either on heat and moisture …show more content…

Apart from hydration, HS has the added benefit of reduction of mucosal oedema by osmosis(8,9). Studies have demonstrated that HS improves mucus elasticity and viscosity(10,11), breaks ionic bonds within the mucus gel (8), improves mucociliary transport(12).
Although, the use of HS has not been systematically studied and compared to NS, at Nottingham University Hospital 7% HS is used in adults with tenacious secretions(11).

Methods

As a quality improvement project, we aim to prospectively evaluate the indications, dose and number of days of nebulised NS, concomitant use of bronchodilators, evidence of airway obstruction, Max Ppeak and Min Ppeak in 24hrs, development of new onset fever/new consolidation on chest x-ray.
All patients admitted to the intensive therapy unit and prescribed NS nebulisation will be added to the study. Data collection will be done daily until the end of the NS nebulisation on the case report form.
This study will also aim to calculate the risk of VAP in the

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