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Myocardial Infarction

Satisfactory Essays

Available online http://ccforum.com/content/12/2/R36

Research
Vol 12 No 2

Open Access

Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings
Wendy Lim1, Paula Holinski1, PJ Devereaux1,2, Andrea Tkaczyk2, Ellen McDonald2, France Clarke2, Ismael Qushmaq3, Irene Terrenato4, Holger Schunemann2,4, Mark Crowther1 and Deborah Cook1,2
1Department 2Department

of Medicine, McMaster University, Canada of Clinical Epidemiology and Biostatistics, McMaster University, Canada 3Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia 4Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy Corresponding author: …show more content…

Conclusion Systematic screening detected elevated cTn measurements and MI in more patients than were found in routine practice. Elevated cTn was an independent predictor of hospital mortality. Further research is needed to evaluate whether screening and subsequent treatment of these patients reduces mortality.

Introduction
Diagnosing myocardial infarction in critically ill patients is challenging [1]. Ischaemic chest pain is uncommon due to analgesic use and communication of ischaemic symptoms – when

they occur – is hampered, since these patients are frequently endotracheally intubated, sedated or comatose. The second challenge in MI diagnosis is that cTn levels are typically only measured in critically ill patients with known coronary artery

APACHE, Acute Physiology and Chronic Health Evaluation; CI = confidence interval; cTn = cardiac troponin; cTnT = cardiac troponin T; ECG = electrocardiogram; ESC/ACC = European Society of Cardiology/American College of Cardiology; ICU = intensive care unit; IQR = interquartile range; MI = myocardial infarction; NSTEMI = non-ST elevation myocardial infarction; OR = odds ratio; STEMI = ST elevation myocardial infarction.

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Critical Care

Vol 12 No 2

Lim et al.

disease, or when MI is considered as an explanation for hypotension or arrhythmia. Thus, it is possible that many elevated cTn levels are never identified and as a result,

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