In this discussion, I will be looking at the different forms of pain and how this pain is caused within the body. The number of different types of drugs used to treat pain is forever expanding but I will examine the main types of painkiller, how they were discovered and how they work to relieve the symptoms of pain.
There are many different types of pain which can be categorised depending on how the pain is caused and how long the pain lasts. If pain results from tissue damage then it is called nociceptive pain and this includes pain from pressure applied outside of the body, like a cut or a burn, or from pressure inside the body such as a tumour. Another type of pain is neuropathic pain which is pain experienced when there is damage to
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These pain relievers are small polypeptide chains made in the brain and are also responsible for the feelings of euphoria encountered when you eat spicy food or after exercise. Opioid drugs mimic the action of these peptide chains, however some enkephalins are a thousand times as effective as drugs such as morphine. Because of this, chemists are trying to synthesise new drugs based on the enkephalins but their duration of analgesic action is short as they can be easily hydrolysed in the body by the enzyme peptidase2.3,10.
Other methods to reduce pain have been around for thousands of years. Hippocrates was the first man to advise people to chew on willow bark as a form of pain relief. However, it was not until 1763 that Edward Stone, an English clergyman, noticed that another property of willow bark was to reduce fever3. Almost one hundred years later in 1860, a compound called salicin was extracted from the willow bark and found to be the reason the bark could provide pain relief. This salicin was hydrolyzed to glucose and salicyl alcohol, which could then be oxidised to salicylic acid4. The bulk of salicylic acid is now produced using the Kolbe synthesis method which is a process that rearranges sodium phenyl carbonate. This chemical is obtained by heating dry sodium phenate under pressure with carbon dioxide, the sodium salt is then decomposed to the acid by dilute hydrochloric acid5 (see figure 1). Derivatives of salicylic
In America, the use of opioids is at an all time high, it has became such an issue nationwide, that it has became an epidemic. Because of the opioid epidemic, America is tearing apart, children all across the country are dying everyday, these children are dying from overdoses due to poisoning. The opioid problem is not just because of a person's decision to pick up a needle or a pill bottle, but it is because in the 1990’s doctors gave up on trying to treat patients for their overwhelming pain and discomfort, causing opioids to become over prescribed. Due to the carelessness of America, opioids are being distributed more and more everyday, causing the skyrocketing number of deaths.
Prescription pain medications are not always an effective treatment for chronic pain. Medications target the pain sensors, but they cannot fix a curved spine. For permanent pain relief, the person needs to try a different treatment option.
The use of medication to relieve pain has become a very controversial topic due to the dependence and addiction aspect of it. Many people are unaware of the variety of alternatives that are available instead of using medication to decrease pain levels. It also isn’t common knowledge that these methods could be just as effective as pain medication.
Specific receptors are stimulated for us to feel this type of pain. These receptors sense changes in temperature, vibration, stretch, and chemicals which damaged cells release. "Nociceptive" means causing or reacting to pain - the cause of the pain comes from outside the nervous system, and the nervous system reacts to it. "Non-nociceptive" means the pain comes from within the nervous system itself.
Patients undergoing surgery and just in general do not have enough pain control. We are a nation that relies heavily on narcotic use. While using pharmacological interventions i.e. pain medication is effective there need to be some alternatives to using pharmacological interventions. I see chronic illness and chronic pain every day where the patient complains that it is not enough and they are sometimes on the max dosage of several different pain medications. The side effects of some medications can be awful and require another medication to help with the side effect of one which can lead to polypharmacy. The problem is we need to have some alternatives to just putting more medications into the body or letting our patients suffer.
what i am about to reveal on this page is a system capt as a secret by high profit organizations, they capt that secret so you will have to pay more over time. a few questions to consider ,how often does your back hurts? or is it your shoulders? maybe its not your shoulders , is it your knees? do you feel tension building up in your neck? does it cause you headaches migraine or stress? do you have problem sleeping at night?
Even though its hurts, its also something that can be helpful to us simultaneously, to an extent. The presence of pain can prevent further damage to an injured area or even prevent an injury from occurring, but pain that continues, after treatment or even after healing, can be debilitating (Loeser and Melzack, 1999). In the past 30 years that pain research has made advances in both the treatment and the understanding of pain. There are three basic categories of pain: transient, acute, and chronic (Loeser and Melzack, 1999).
Pain is subjective and numerous factors may affect individuals pain experience, with physical, emotional, psychological, spiritual and cultural wounds. The severity of pain, however, depends on the individuals who are dealing with It (noble, 2006) As such no one approach to pain is effective for all kinds of individual pain experiences. For instance, Physical pains could be easily treated with pharmaceutical medications while emotional, psychological, spiritual and cultural pain are treated best by finding a resolution to the source of pain. Therefore, nonphysical pains are the most difficult pain to treat for they are not always real but perceived. Nevertheless, pharmaceutical medications are helpful to alleviate nonphysical pain temporarily
There are several point in the pain pathway where the signal can be modify your nervous system is made up of two main parts your brain and your spinal cord. Doctors and other professional use a person pain as a clue in figuring out what's wrong about 70% of people with chronic pain treated with pain medication. While care has grown more sophisticated the most effective care still is not widely available.
Chronic Pain is a major health problem for many people, and it is defined as pain that persists or progresses for more than three months. Chronic pain can be related to many other medical conditions such as cancer, fibromyalgia, diabetes, and arthritis as well as previous injury. Studying chronic pain is important because inadequate treatment of chronic pain significantly reduces many people’s ability to be active participants in their daily activities, which has the potential of negatively affecting employment status and could possibly lead to depressive and anxious symptoms in people with chronic pain. While there are increasing types of drug regimens to manage and relieve some aspects of chronic pain, the main source of persistent pain
Everyone loves pain relievers for one thing, their ability to take away all the sores and pain from whatever ails at the moment. However, the FDA is strengthening its warning about pain relievers and how they increase the risk for heart attack and stroke from the ingredient known as NSAID or Non-Steroidal Anti-Inflammatory Drug (http://www.webmd.com/arthritis/features/pain-relief-how-nsaids-work).
Despite all the advances erupting from therapeutic research, current treatments for pain management remain inadequate. The efficacies of modern pain therapies are challenged by “adverse tolerability profiles, unfavourable side effects, concerns with long-tern use and potential for misuse or abuse” (Carven & Roberts, 2013). While the major analgesic medicines on the market today include “narcotic (opioids) and non-narcotic analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), and heat therapy” (Carven & Roberts, 2013), engineered biologics are emerging as a promising approach to reconcile various inadequacies of existing pain therapies, since they can be manufactured with capacities such as target specificity to minimize unnecessary, adverse reactivity.
Pain can be classified based on its type. It can be acute, cancer or chronic of by pathophysiology that can either be visceral or somatic. Neuropathic pain is the pain ensuing from injury to the tissues hence causing nerve dysfunction. Neuropathic pain is therefore described as a shooting, throbbing, or cold sensation. Cancer pain can also be defined as the pain that arises from both neuropathic and nociceptive pain. It is therefore important to identify the mechanisms as well as different forms of pain considering that selective treatment helps improve the outcomes of pain control.
Pathophysiology and pharmacology of pain remain complex despite of the recent advancements in pain molecular and neurobiology (1, 2). Current findings suggest several new drug targets such as transient receptor potential (TRP) channels, voltage-gated potassium, sodium channels, imidazoline receptors, cholecystokinin (CCK) receptors and novel strategies like designer receptor G protein coupled receptors (DREADDs) and optogenetics for the pain management (3-5). Enzymes of the endocannabinoid cascade such as N-Acylphosphatidylethanolamine-selective phospholipase D (NAPE-PLD), Fatty acid amide hydrolase (FAAH), Diacylglycerol lipase (DAGL) α, α, β-Hydrolase domain containing 4, (ABHD-4), ABHD-6, ABHD-12 and Monoacylglycerol lipase (MAGL) and the
Animals have slowly been showing up more and more in common spaces, from a cat boarding a plane to dogs being allowed more freely in areas generally thought of as pet free. Therapy dogs have begun roaming the halls of schools, and puppies have been popping up in the local therapist's office. This animal friendly phenomena has been growing over the years and it is greatly due to the rise in mental health awareness and increase of new treatment methods such as Animal Assisted Therapy - also known as Animal Assisted Intervention. Animal Assisted Therapy (AAT) seems to be helping broaden the scope of possibilities in treatment options for the sick and the overall acceptance of animals.