Pathophysiology Of ACS Essay

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Pathophysiology of ACS:

The pathophysiology of ACS occurs as sequelae of atherosclerotic plaque rupture, which leads to thrombus formation that results in reduction of coronary blood flow which further causes myocardial ischemia.5 American College of Cardiology divided ACS to three segments, which include; unstable angina, ST segment elevation-ACS (STE-ACS) and, non-ST segment elevation myocardial infarction (NSTE-ACS). 4


NT-pro-BNP is one of the natriuretic hormones that belongs to the vasoactive peptide group which can be measured in the blood.15 NT-pro-BNP release is triggered by volume or pressure overload/myocardial Ischemia and increases as necrosis to myocardial muscle proceeds.12 This biomarker holds a promising future in determining the prognostic and diagnostic value in the setting of ACS, which will be effective in the utilization of health care setting to assess patients’ outcomes.14
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The results of this study showed that high levels of NT-pro-BNP are superior and are independent predictors of short-term mortality compared to cTn I in ACS patients. The authors concluded that NT-pro-BNP maybe utilized in clinical practice for risk stratification in patients with normal cTn I levels.6
NT-pro-BNP has become well known as one of the diagnostic tools in heart failure and acute dyspnea, but its role in ACS is not very well established. Even though it has been used as a risk predictor, NT-pro-BNP does not have a strong diagnostic value in ACS.15
The prognostic value of NT-pro-BNP has been investigated in several studies, it has been suggested that one measurement of NT-pro-BNP in the early period of diagnosis of ischemic episodes provided prognostic importance in ACS. The increased levels of NT-pro-BNP in STE-ACS, NSET-ACS and, unstable angina provided predictions of increased risk of
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