Plasticity Of Mesenchymal Stem Cell

3461 Words Oct 21st, 2014 14 Pages
PLASTICITY OF MESENCHYMAL STEM CELL
INTRODUCTION
Mesenchymal stem cells (MSC), also regarded as marrow stromal cells, are multipotent adult stem cells that are able to differentiate into limited mesodermal lineage and are able to self renew. MSCs possess characteristics that make them useful in regenerative medicine including, immunomodulation, secretion profile and homing characteristics. Depending on where they are used, these characteristics can have a positive and negative influence on the disease. This review will focus on the immunomodulatory characteristics of MSCs, several isolation points of MSCs, and differentiation which make them useful tool in treatment of post myocardial infarction, diabetic foot disease (wounds), immune disease and their role in cancer progression.
HISTORY OF MSCS
The presence of MSCs dates as far back as the 19th century but in 1960 Friedenstein and colleagues described MSCs as a group of stromal cells isolated from bone marrow that were plastic adherent , colony forming and able to differentiate into bone, stromal and hematopoietic tissues.1 Over the years what is known about MSCs has evolved, described and defined by several scientist but in 1990 the term “mesenchymal stem cell” as coined by Caplan2 and in 2006, the international society for cell therapy defined MSCs as cells that express all of these three characteristics: (a) plastic adherence in culture conditions (b) expression of surface markers CD105, CD73, CD90 but not…
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