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Postmortem Interval Estimation

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Abstract Postmortem interval estimation is very important in a suspicious death investigation. Myoglobin is a hemoprotein present in striated muscles of living body. After death, myoglobin is exuded from muscles to blood, tissues and organs. So, the aim of this study was to estimate postmortem interval from myoglobin concentrations in glandular tissues. This study was done on rats to detect the postmortem concentration of myoglobin in pituitary, parotid and adrenal glands at different time intervals. There was a significant correlation between myoglobin concentration in glandular tissues and postmortem interval. By multiple stepwise linear regression analysis, the most predictable model was the combination between pituitary, adrenal and parotid myoglobin concentrations (R2= 0.992). The second predictable model was the combination between adrenal and pituitary myoglobin …show more content…

Following irreversible cardiac arrest and death, cessation of cellular metabolic activity occurs. These changes are both biochemical & structural. Biochemically, cellular breakdown occurs due to the conversion of the cellular metabolic pathways to autolytic activity and structurally changes occur in tissues & decomposition appears well [4]. There are 2 stages of death, somatic (immediate death) and cellular death. In somatic death, there is loss of movement, cessation of respiration and circulation [5]. The stage of cellular death includes eye changes in the form of loss of corneal reflex, shrunked eye and pale retina. Algor mortis (body cooling), hypostasis, rigor mortis are early postmortem changes that occur in cellular death. Late postmortem changes include putrefaction. The process of postmortem decomposition could be divided into five stages: Fresh (autolysis), putrefaction, black putrefaction, butyric fermentation and dry decay. These gross changes will be quite unreliable with times [6,

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