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Pretreatment Differentiation of Renal Cell Carcinoma Subtypes by CT

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The study presented in the article „Pretreatment differentiation of renal cell carcinoma subtypes by CT: the influence of different tumor enhancement measurement approaches“ was designed as a continuation of previously performed similar uroradiologic studies in the field of renal cell carcinoma (RCC) differentiation with minimally invasive cross-sectional imaging methods such are ultrasound, computed tomography (CT) and magnetic resonance imaging. In this study, differences in enhancement between solid forms of clear cell RCC(ccRCC) and other subtypes of RCC (papillary, chromophobe, and collecting duct RCC) measured using two distinct techniques were retrospectively assessed to determine the most accurate and simple method of assessing tumor enhancement. The results of these solid renal carcinomas enhancement measurements were expressed in the form of tumor attenuation values and tumor enhancement ratios with formulas originally defined by Herts et al.(Herts BR, Coll DM, Novick AC, et al. Enhancement characteristics of papilary renal neoplasms revealed on triphasic helical CT of the kidneys AJR Am. J. Roentgenol. 2002;178:367-372), and were then correlated with pathologic reports (tumor histologic subtype). The cutoff number for each approach to the tumor enhancement measurement was chosen in order to achieve apropriate sensitivity-specificity balance with emphasis on the specificity. To the best of our knowledge, this is the first report to examine CT-based solid renal

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