Pros And Cons Of Third Generation Vaccines

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However, third generation vaccines are considerably more immunogenic, than HBsAg due to their uses of pre-S1 and pre-S2 antigens, but they aren’t used widespread yet. Third generation vaccines are also manufactured with recombinant DNA technology by mammalian cells (155) (156)
1-13-3-1 High risk Groups should be administered HBV vaccine:
 All infants, preferrably before hospital discharge at birth. (Additionally, infants born to HBsAg-positive mothers need HBIG within 12 hours of birth.)
 All children and adolescents not previously vaccinated.
 All individuals at risk of HBV infection:
 Persons with occupational risk like health care workers (HCW).
 Clients or staff of institutions for the developmentally disabled
 Hemodialysis patients

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