Recently we have been studying genetic disorders. We were given the opportunity to choose what genetic disorder that we wanted to learn more about by writing a paper about the disorder. The topic at hand is one that hits close to home to everyone at Milford High School. In a recent, disappointing, and discouraging loss, Milford lost one of its own members of its student body to this serious disorder. Rhabdomyosarcoma is a soft-tissue cancer that grows in the muscle cells of young adolescents. The disorder is a disease in which malignant cells begin growing in muscle tissue. Rhabdomyosarcoma is a type of a sarcoma, which means a cancer of the bone, soft tissues, or connective tissue (e.g., tendon or …show more content…
Several tests can be run once symptoms are noticed to earmark the disease with a proper diagnosis. Some of the tests include; a biopsy of the tumor, X-rays, a CT scan, a skeletal survey, bone scans or bone marrow aspiration (fluid sample) and biopsy (tissue sample). Once diagnosed, the treatments begin to hinder any advancement the cancer would or could make. Possibly removing the cancer completely through surgery is a possibility, while others include chemotherapy, radiation treatment, and bone marrow transplantation. Many times these treatments can be used concurrently with one another.
“In the Rhabdomyosarcoma (268210) cell line TE125.5, Schwienbacher et.al (1988) found a G-to-A transition at nucleotide 688 that introduced an arginine in place of a cysteine in the product of the BWR1A gene. The change was present in a homozygous state, suggesting that loss of the normal allele occurred during the tumorigenic conversion.” (John Hopkins University, 1998.) A number sign (#) is used with this entry because of evidence that Rhabdomyosarcoma, which maps to 11p15.5, is caused by mutation in the Beckwith-Wiedemann region 1A gene.
Screening tests are only available through biopsies. This means that basically once symptoms arise, one would be able to go and get a prognosis as to whether or not they have this disease.
Genetic
Many people believe that the symptoms of cancer are not present until the malignant tumor has spread beyond the stages at which it can be treated. This is not entirely true. Some types of cancer tend to be particularly "elusive" and do not manifest themselves in any way. However, most forms of the condition have noticeable symptoms. The problem is that they are usually similar to the ones of common and much less serious illnesses.
Rhabdomyosarcoma is an awfully common childhood and adolescent sarcoma characterized by skeletal muscle differentiation (Carroll & Nodit, 2013). According to the American Cancer Society (2014), rhabdomyosarcoma is a lot more prevalent in children due to the fact that rhabdomyblasts start to form approximately seven weeks into the development of an embryo and these are the cells that
Diagnosis of cancer typically requires obtaining a tissue specimen from the patient by a doctor. A histologic exam of the tissue specimen is performed by a pathologist to determine if cancer is present. If you're diagnosed with a form of cancer then you certainly want to contact a cancer treatment center through your doctor and obtain the treatment that is right for you. Many of
Surgery is often the initial treatment for the cancer. The tumor, a portion of the intestines and lymph nodes are surgically removed and sent to a pathologist for examination. The healthy portion of the intestines are then re-attached. If the cancer has spread to the lymph nodes, chemotherapy is used to kill the remaining cancer cells.
On which can help the patient who has this cancer be able to live for a more longer time than back then where you aren’t able to stop the cancer cells to affect the rest of your body. Some test perform to help with the research to help scientist and also doctors to help detect and be able to stop the source it’s by looking at ultrasounds. As well as not only that but also CT Scanning, MRI, and even ERCP. Thanks to this technology doctors are able to treat these cancer by doing series of surgeries to extract tumors created and remove the organs or parts where it's most affected by the cancer. Another possible cure for this cancer is chemotherapy which is basically usage of certain chemicals and even specific
Treatments: the treatment options depend on the type and stage of the cancer that the patient has. These treatments can include, surgery, radiation therapy, chemotherapy and stem cell transplants. Occasionally more than one type of treatment might be
Depending on the stage of the cancer can depend on what kind of treatment is given. The treatment can consist of chemo
Rhabdomyosarcoma is a tumor of undifferentiated skeletal muscle and is considered to be the most common soft tissue sarcoma in children, representing 3% of all pediatric malignancies in the United States (Ojo, Chen, Pelaez, & Younis, 2014). RMS is more common in Caucasians than African Americans (3:1) and in males than females (1.5:1) (Wang, 2011). In order to accurately diagnose rhabdomyosarcoma a thorough clinical workup is performed. The workup begins with a clinical examination and history, where gathering information such as family history of genetic syndromes, associated conditions and signs and symptoms are crucial. Research has revealed negative association between RMS and environmental factors, however, a family genetic history of neurofibromatosis (NF1), Li-Fraumeni syndrome,
The cells are then sent out to a laboratory for testing. This generally takes two weeks. Most labs use the Bethesda System SIL to measure the amount of cell changes, if any. This system measures “normal” at one end of the chart, to “invasive cancer” at the other end. Generally it is difficult to determine the stage or grade of cell changes which occur. This often means diagnosis and treatment are difficult to make. (623).
Your doctor takes a small piece of tissue from your stomach to look at under a microscope for signs of cancer cells. He might do this during an endoscopy. If you need to do the surgery to cure the cancer,the treatment that your doctor picked for you depends on how long you’ve had the disease or how much it has spread in your body. So is the surgery.
The most common treatments are: surgery- to remove the cancerous tissue and even the limb if necessary, radiation therapy- shooting high powered beams of energy into the cancerous cells, chemotherapy- a drug treatment used to kill cancerous cells, or targeted drug treatment- which blocks certain chemical signals from occurring and is also a bit newer (Mayo Clinic Staff). Unfortunately, one must also consider what stage the cancer has advanced to, for if it has reached somewhere such as stage II, III, IV, it may be very difficult or nearly impossible to treat it and be successful since the cancer is do advanced. It is advised to make healthier choices such as eating better, exercising, and resting, but most people are also advised with doing that also (American Cancer
Bone cancer is caused by an error in a cell’s DNA. The error tells the cell to grow
Radiation therapy is another treatment that can be done. This is where doctors deliver doses of radiation to the tumor. If the treatments above do not work, chemotherapy, the use of chemicals or drugs, would be the next approach for trying to get rid of the tumor. Even after all that, the patient still has to go back to their doctors for more tests. I cannot remember everything when I was younger but I do remember visiting my farther in hospitals all the time. I think I spent more time with him in the hospital than any other time in my life. I look back now with regret that I did not spend as much time with him when he was home, I wish I would have!
Osteosarcoma is the most common type of bone cancer. Approximately 800 new cases of this disease are diagnosed in the United States every year and about 400 of these are in children and teens (American Society). This type of bone cancer commonly affects adolescents and young adults, but is not limited to this age range. This cancer occurs about twice as often in males than females. This illness can undoubtedly emerge in any bone but most of the times it occurs in long bones before possibly spreading to others areas of the body. The negative impact that Osteosarcoma has on patient’s life is not different from other cancer patients. It is important to inform others about what Osteosarcoma is, how it is diagnosed and treated, and explain organization and research being done in order to create better awareness about this condition because it is life threatening.