Rheumatoid arthritis is an autoimmune and systemic disease damaging many joints in all parts of the body. In this state, body’s immune system activates a self-regulated immunological cascade that ultimately leads to joint damage. Rheumatoid arthritis begins in synovial tissues attached to the joints and then extends towards cartilage. It is described by
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. While inflammation of the tissue around the joints and inflammatory arthritis are characteristic features of rheumatoid arthritis, the disease can also cause inflammation and injury in other organs in the
Rheumatoid arthritis is a systemic disease that affects whole systems of body particularly cardiovascular system, nerves, respiratory system (RACGP, 2009). The causes of rheumatoid arthritis are unknown but it is hereditary which assists to have a risk of rheumatoid arthritis by 50%-60% (RACGP, 2009).
Rheumatoid Arthritis(RA) is the most common type of autoimmune arthritis. RA is a progressive and debilitating musculoskeletal disorder that affects the joints symmetrically, causing a range of systemic effects. What it causes is still not well known; nevertheless, findings of new research points towards a believe that it is triggered by a defective immune system, which causes the release of inflammatory chemicals. These chemicals cause damage to cartilage and bone, usually affecting the wrists, the joints of the hand, including the knuckles, the middle joints of the fingers and feet. While this condition can affect any joints, besides, important body organs such as the eyes and the lungs can also be affected by the inflammation that occurs as a result of this chronic condition. Only in America 1.3 million of people are affected by this ailment, and 75 % of them are mainly women. Its onset usually occurs between fourth and sixth decades; however, RA can occur at any age("Diseases And
Rheumatoid arthritis is a chronic syndrome that is characterized by inflammation of the peripheral joints, but it may also involve the lungs, heart, blood vessels, and eyes. The prevalence of this autoimmune disease is between 0.3% to 1.5% of the population in the United States (Feinberg, pp 815). It affects women two to three times more often than men, and the onset of RA is usually between 25 and 50 years of age, but it can occur at any age (Reed, pp 584). RA can be diagnosed by establishing the presence of persistent joint pain, swelling in a symmetric distribution, and prolonged morning stiffness. RA usually affects multiple joints, such as the hands, wrists, knees, elbows, feet, shoulders, hips, and small
Rheumatoid arthritis is a chronic, systemic inflammatory autoimmune disease. The disease happens when the immune system mistakenly attacks a healthy tissue as if it was a foreign invader, such as a virus or bacteria. If left untreated it can lead to permanent joint damage, decrease in quality of life, and total disability. It affects over a million people in the U.S. alone. Rheumatoid arthritis symptoms include persistent joint inflammation which causes joint pain, stiffness, and swelling. Fatigue and stiffness are usually early symptoms. Joint pain can be an early symptom in a variety of diseases. Symptoms of rheumatoid arthritis often develop slowly over a period of weeks or longer, but this is not always the case, it can have an acute
Many people all over the world may have rheumatoid arthritis. Rheumatoid Arthritis is a chronic inflammatory disorder that affects the small joints in the hands and feet (Mayoclinicorg, 2015). It is also an autoimmune disease, where the immune system sees the body as a foreign object and attacks it (Mayoclinicorg, 2015). As the chronic disorder matures, it could seep into the blood vessels and into other organs: heart, lungs, skin, and eyes (Mayoclinicorg, 2015). This chronic pain is found mostly in women around forty to sixty years old; however, men with low testosterone could also have the chronic disorder (Mayoclinicorg, 2015). Because smokers burn off certain cells to prevent infection, they are also at risk for rheumatoid arthritis. This
Rheumatoid arthritis is a chronic autoimmune disease that is characterized by inflammation and destruction of the joints (1). It usually affects joints asymmetrically, or on both sides of the body
Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease that is systemic in nature but primarily targets and damages the synovial joints. It is characterized by painful, swollen, stiff joints, which manifest primarily in the hands, wrists, elbows, knees, ankles, and feet. RA is more common among women than men and increases in prevalence with age, however it can also occur in young adults and children (Lee & Weinblatt, 2001).
Occurs when the immune system attacks the synovium (lining of membrane surrounds the joints). The resulting inflammation thickens the synovium, which can eventually destroy the cartilage and bone within the joint. The tendons and ligaments that hold the joint together weaken and stretch. Gradually, the joint loses its shape and alignment. While your genes don 't actually cause rheumatoid arthritis, they can make you more susceptible to environmental factors — such as infection with certain viruses and bacteria — that may trigger the disease. Immune system starting to attacks own body 's tissues mistakenly.
Rheumatoid arthritis (RA) is an autoimmune disease where the body’s immune system protects the body’s health by attacking unknown substances like bacteria and viruses, and mistakenly attacks the body’s joints. This creates inflammation causing the tissue that lines the inside of joints to thicken, which results in swelling and pain in and around the joints. The tissue makes a fluid that lubricates joints and helps them move smoothly. If inflammation goes unchecked, it can damage cartilage, the elastic tissue that covers the ends of bones in a joint, as well as the bones themselves. Over time, there is loss of cartilage, and the joint spacing between bones may become smaller. Joints can become
Rheumatoid Arthritis is a systemic autoimmune disorder. There are more than 100 different types of Arthritis, yet it is estimated that it affects approximately 1% of the population in the Western World. The disease is generally diagnosed in middle aged adults and the elderly. In rarer cases, children can also develop the disease and it is called Juvenile Rheumatoid Arthritis. Women are three times more likely to have rheumatoid arthritis than men. (Stevens) Many people living with Rheumatoid Arthritis appear to be healthy individuals, but suffer internally. Today, I will discuss what rheumatoid arthritis is, how it is diagnosed, and how it affects the body.
“It occurs worldwide and, until age 65, is three times more common in women than men” (Rosdahl and Kowalski, 2012, p.1235). However, this disease is more common in the middle aged- elder adults. It is considered an autoimmune disease because the body will begin to attack its own body tissues. Rheumatoid arthritis can also cause harm to other body systems (systemic), such as the cardiovascular system resulting in issues of blood vessels, the integumentary system causing issues with the eyes and skin, and of the respiratory system which can cause problems of the lungs (Staff, 2014). Hypothyroidism is a disease that is the most closely associated autoimmune disease to rheumatoid arthritis, and its characteristics are determined by a rheumatologist to rule out and distinguish between the two diseases (Vij and Kumar,
Rheumatoid arthritis is an autoimmune disease in the general family of lupus. For reasons that are not understood, in rheumatoid arthritis the immune system goes awry and begins attacking tissues, especially cartilage in the joints. Various joints become red, hot, and swollen under the onslaught. The pattern of inflammation is usually symmetrical, occurring on both sides of the body. Other symptoms include inflammation of the eyes, nodules (or lumps) under the skin, and a general feeling of malaise.
Thank you Prianca for taking the time to share about the cytokines and their interaction in the inflammatory process of the Rheumatoid Arthritis. Indeed, the epidemiology incidence of Rheumatoid arthritis (RA) is increasing every minute. Like you well explain above in your post, we have more than 1.3 million of people in the US affected with RA (Ruderman & Tambar, 2013) and 1 percent of the worldwide population is affected with RA (Lubberts & Berg, 2003). It seems like this epidemic is going to continue. 75 percent of that 1.3 million are women, and statistically, 1 of 3 women may get rheumatoid arthritis in their life. Rheumatoid arthritis can affect anybody at any age, but in most of the cases, the disease begins in the 40’s and 60’s (Ruderman & Tambar, 2013).