Risk For Developing Kidney Disease

According to the office of the minority health, approximately 48% of African American women and 44% of African American men suffer from some form of the cardiovascular disease which includes heart disease and stroke and adults are 40 percent more likely to have high blood pressure while the women are 1.6 times more likely to die from heart diseases and complications than other ethnic groups (The Office of Minority Health, 2016).

Chronic kidney disease (CKD) is a worldwide problem that is currently three times higher for African Americans, Hispanics, Pacific Islanders, American Indians and seniors (The National Kidney Foundation, 2013). CKD occurs when the kidneys are damaged by a pathogen or injury and they can no longer adequately maintain proper levels of regulated chemicals in the bloodstream. There are many risk associated with CKD. According to the National Kidney Foundation, two of the major risks are Chronic Renal Failure (CRF) and Cardiovascular Disease. Currently twenty million American adults have CKD and millions of others are at increased risk. Age has no barrier on getting CKD. People with pre-existing health issues, and a part of certain population

(2012) suggest that, “genetic ancestry has a significant association with type 2 diabetes above and beyond its association with non-genetic risk factors for type 2 diabetes in African Americans, but no single gene with a major effect is sufficient to explain a large portion of the observed population difference in risk of diabetes. and that there is a interplay among specific genetic factors, which may both be associated with overall admixture, leading to the observed ethnic differences in diabetes

Socioeconomic status is a health disparity in the United States. In 2012, McHenry concluded that there are approximately 84,000 preventable deaths that occur each year. Although the ACA has provided accessible health care to many people that would otherwise not be able to afford health insurance there still is a large population uninsured (Brown & Divenere, 2017). African Americans have a high prevalence of

African Americans are the third largest racial or ethnic population, totaling 13.2% of the United States population (CDC, 2015). Giger (2013) states, some health disparities associated with African Americans is due to discriminatory practices and inequalities in social, economic, and educational opportunities, rather than biological factors. Statistics identifies higher health disparities for this population reflected in overall mortality rates compared to other populations. According to the Office of Minority Health (2014), the adult mortality rate is higher in African Americans for heart disease, stroke, cancer, asthma, influenza, pneumonia, and diabetes, as well as higher rates of infant mortality. For instance, the overall adult mortality rate for African Americans is 860.5 per 100,000 population compared to 731.0 per 100,000 population in Caucasian Americans according to 2012 data (KFF, 2015).

“researchers have repeatedly documented racial and ethnic differences in access to invasive diagnostic and therapeutic interventions for heart disease and stroke. Study findings have consistently indicated that African Americans are less likely to receive pharmacological therapy, diagnostic angiography and catheterization, and invasive surgical treatments for heart disease and stroke relative to white Americans with similar clinical disease characteristics (2000).”

Race-based medications seem highly personalized to the consumer but are simply a short cut to the goal of individually-specific medication. Marketing drugs targeted at particular phenotypes such as race is incredibly lucrative for pharmaceutical companies. For NitroMed, this factor will be especially important because African Americans have far higher cases of hypertension than whites while tending to be less responsive to normal treatments than their white counterparts.

“Minorities were referred less for cardiac cath, received less pain medication for fractures, received less surgical treatment of lung cancer, received fewer referrals for renal transplant, received fewer referrals for congestive heart failure and pneumonia, and received fewer major procedures for myocardial infarct (in the elderly) (Thomas, 2014, p. 7495).”

Hypertension is a developing problem worldwide associated with an increased risk of cardiovascular morbidity and mortality. In 2020, the world population will be approximately 7.8 billion people, and there will be 1 billon people who may be affected by hypertension (Tomson & Lip, 2005). One in three adults in the United States has high blood pressure. According to the report “Health, United States, 2010 with Special Feature on Death and Dying,” the prevalence of hypertension among adults 20 years old or older increased from 24% to 32% during 1988-1994 and 2005-2008. The African-American population has a higher prevalence of this health condition than white Americans do. In 2005 to 2008, the prevalence of hypertension among black males (41.4%) was more than 10%,

Chronic kidney disease (CKD) is an irreversible condition that progresses causing kidney dysfunction and then to kidney failure. It is classified by a GFR of <60mL/min for longer than 3 months. There are five stages of CKD: Stage 1 has kidney damage but has a GFR ≥ 90. Stage 2 has mild damage and a GFR of 60-89. Stage 3 has moderate damage and a GFR of 30-59. Stage 4 has severe damage and a GFR of 15-29. Stage 5 is also known as end stage renal disease (ESRD), this is kidney failure with a GFR of ≤ 15 and theses patients are typically on dialysis or in need of an immediate transplant. The leading cause of CKD is diabetes. Hypertension is also a major cause. Since most DM patients have HTN,

Chronic Kidney Disease (CKD) is among the leading causes of mortality throughout the world, and its prevalence and the health care costs resulting from it are considerable and increasing. CKD commonly is silent and asymptomatic until its late stages. Accordingly, CKD is diagnosed prior to symptomatic stage of kidney failure, resulting in delays in proper interventions and the emergence of adverse consequences in the CKD patients

Diabetics is the most common cause of CKD, and accounts upto 60% of people who develop ESKD.

Kidney failure is a public health problem, which has dramatic effects on patients' health. In some

Factors that contribute to hypertension are age, ethnicity, gender, and lifestyles as shown in Figure 1 (Yoon, Burt, Louis, & Carroll, 2012). While the prevalence of hypertension is relatively equal among men and women, certain ethnicities have a higher propensity for developing hypertension. The prevalence of hypertension in African-Americans is among the highest in the United States for a single ethnic group (Ferdinand & Armani, 2007). In the United States, around 78% of people suffering from hypertension are aware of their condition, with only 68% using hypertensive medications to control their blood

In the U.S. kidney disease is the 8th leading cause of death with an estimated 31 million people having chronic kidney disease. Women are more likely to have chronic kidney disease than men. Compared to whites, African Americans chance of developing this disease is 3.8 times higher, Native Americans risk is 2 times higher, and Asians it is 1.3. Diabetes