Sickle Cell Disease Sickle cell disease is a hereditary blood disorder caused by an abnormal hemoglobin in the red blood cell. Hemoglobin is a type of protein that carries oxygen in the body. In order for someone to have sickle cell disease they would need to have been passed down from at each one of their parents, by inheriting a total of two hemoglobin genes. The fact that this is a hereditary disease means that it is not considered to be contagious. This disease comes in about six different forms, but the most severe of them all is sickle cell anemia. Sickle cell is an inherited disease that affects the red blood cells causing debilitating symptoms, however, with treatment people with this disease can quite possibly live an otherwise …show more content…
(NHLBI, 2015) There are a few scenarios of the passing of the disease or trait from the parent to the offspring. If one parent has the gene it can be passed to the child, causing the child to be a carrier of the trait. In other words, the child will be able to produce normal hemoglobin as well as the sickle shaped hemoglobin. They will also be able to pass it to their offspring. If both parents carry the trait the child has a 50 percent chance of being a carrier, percent chance of not getting the gene at all, and 25 percent chance of having sickle cell anemia. In most cases, people with sickle cell begin experiencing symptoms at the age of 4 months’ symptoms include fatigue which happens due to the loss of red blood cells after they rupture as they are extremely fragile. Another symptom will be the pain, it develops when other is a blockage within the blood vessels in your chest, abdomen, and joints. Intensity varies and can even lead to hospitalization. Delayed growth and vision problems of blood cells blocking areas of the body. You are more prone to infections and will also experience swelling of the hands and feet. The gene is most common in countries such as Africam India, Mediterranean countries, Sauda Arabia, the Caribbean islands, South and Central America, and also in the United States. According to American Society of Hematology, the United States, sickle cell is mostly in the black community.
When the sickle cells go through they can block up blood vessels and cause severe pain, fatigue, paleness, rapid heart rate, shortness of breath, and/or yellowing of eyes and skin. This can also start in early childhood and cause you to have a low number of red blood cells. This disorder can affect major organs such as lungs, kidneys, spleen, and brain. Anemia can cause shortness of breath, fatigue and Delayed growth development. The severity of the pain varies from person to person. The pain is usually medium to
People with sickle cell anemia also may have bouts of pain in the chest, stomach, arms, legs, or other parts of the body. This is caused by sickle cells blocking blood flow through the blood vessels. Feeling tired and having trouble fighting
In this article, sickle cell anemia is defined as a hereditary disease that destroys red blood cells by causing them take on an elongated and rigid "sickle" shape. In addition, a different type of hemoglobin called Hemoglobin S, is the protein in red blood cells that carry oxygen throughout the body. This protein starts to wrap around other red blood cells when oxygen is lacking to form a helical shape. Once this happens the cells cluster together and elongate and the cells start to "sickle". A person who has sickle cell anemia can only get it if both of their parents carry the sickle cell trait, if only one parent has the trait then there children are at risk for having the trait.
Sickle cell anemia can produce mild to severe symptoms and complications. Anemia symptoms are tiredness, irritability, dizziness, lightheadness, a fast heart rate, difficulty breathing, pale skin color, jaundice, slow growth and delayed puberty. Hand-foot syndrome which is usually the first symptom of sickle cell anemia is the swelling of the hands and feet (“Facts About Sickle Cell Disease,” 2016). The signs and symptoms can vary from person to person and change over time in sickle cell anemia (https://www.nhlbi.nih.gov/health/health-topics/topics/sca/signs). Over time sickle cell anemia can worsen. (“Facts About Sickle Cell Disease,” 2016)
Sickle cell is a blood disease. People with sickle cell anemia have crescent moon shaped blood cells that are hard and sticky. When the Sickle cells move through blood tubes, they can clog blood flow and break apart. This can cause main, damage, and a low blood count. The symptoms of the disease are not life threatening, however are not enjoyable. Sickle cell anemia can cause you to experience dizziness, headaches, and shortness of breath. Your skin may also turn more yellow or pale than it usually is. Sickle cell is an inherited disease. It is an unpreventable disease that you are born with. If you have a sickle cell gene, you do not have sickle cell, however your children have a 25% chance of having sickle cell anemia. This blood disorder can cause pain and discomfort but it is unlikely that your life will be in danger if you have the disease.
Sickle cell disease is an inherited form of anemia. This means both parents must pass on the defective gene for a child to be affected. The gene is more common in families that come from Saudi Arabia, Africa, Mediterranean countries, India, the Caribbean islands, and North, South, and Central America of African descent.
Not only this disrupts oxygen from delivered, but the lack of oxygen also results in pain or crises for most. For children the pain scale can be from zero to very little pain, but for adults the pain may be severe. Doctors will often recommend the person to drink large amounts of liquid and take medications for instance ibuprofen. People with this disease are usually very tired and have a decrease in red blood cells. A normal red blood cell lives up to 120 days and automatically kills itself. A sickle cell lives up to 14 days so the body cannot necessarily keep up because the cells are rapidly
Sickle cell anemia is a severe condition in which there aren’t enough healthy, round red blood cells to carry adequate oxygen throughout your body. It is a form of anemia in which a mutated form of hemoglobin--a red protein responsible for transporting oxygen in the blood of vertebrates--distorts the red blood cells into a crescent shape. This causes low oxygen levels. Normal red blood cells are flexible and round allowing for easy movement throughout your blood vessels. In sickle cell anemia, the red blood cells are rigid and sticky and are shaped like a crescent moon--or a sickle. The effect is the red blood cells get caught in small vessels and block blood from reaching different parts of the body. This can cause pain and tissue damage.
Most adolescents and adults with Sickle Cell anaemia suffer from chronic pain, stemming from frequent pain episodes which occur when oxygen levels are decreased caused by sickle cells blocking blood flow. These pain episodes are commonly known as acute sickle crisis. It is believed that these episodes can be triggered by a secondary illness, temperature, stress and dehydration (G.Gibbons
Hemoglobin is a protein within erythrocytes responsible for binding, carrying, and delivering oxygen throughout the body. These disorders are inherited and therefore not contagious. For an individual to have sickle cell anemia each of their parents must have an abnormal hemoglobin gene and both of these genes must be expressed.
Sickle cell disease (SCD) is an inherited and noncontagious, lifelong condition. More specifically, per Ohaeri, Shokunbi, Akinlade, & Dare, 1995, SCD is a generic term for a group of genetic disorders characterized by the predominance of sickle cell hemoglobin (Hgb). Hemoglobin is a protein in the red blood cells that carries oxygen throughout the body. The disease produces significantly abnormal Hgb molecules in red blood cells (RBCs). In sickle cell anemia, the red blood cells become rigid and sticky and are shaped like sickles or crescent moons. These irregularly shaped cells can get stuck in small blood vessels, which can slow or block blood flow and oxygen to parts of the body (Ohaeri, Shokunbi, Akinlade, & Dare, 1995, p. 955.Individuals
Sickle-cell anemia is a genetic disease. People who are affected have two copes of the mutant gene. Normally, if a patient is heterozygous for the sickle-cell gene, they do not display any symptoms of the disease. Sickle-cell anemia is characterized by a deformation of red blood cells that are elongated and resemble sickles. In sickle-cell disease, mutated hemoglobin binds together to form large masses, which give the red blood cells their sickle shape. The hemoglobin found in this disease is referred to as hemoglobin S (Hb S), as opposed to normal adult hemoglobin, hemoglobin A (Hb A).
Normal red blood cells live about 120 days in the bloodstream and then die. They carry oxygen to and remove carbon dioxide from the body. In sickle cell anemia, the abnormal cells usually die after only about 10 or 20 days. The bone marrow can't manufacture new red blood cells quickly enough to replace the abnormal cells that are dying, leading to a seriously low red blood cell count. The signs and symptoms of sickle cell anemia vary widely. Some people have mild symptoms, such as fatigue, dizziness, jaundice, and shortness of breath. Others have very severe symptoms and often are hospitalized for treatment, usually needing blood
Sickle Cell Anemia or Sickle Cell Disease is an inherited blood ailment. Those suffering from Sickle Cell Disease have abnormal S/ sickle hemoglobin in the red blood cells. Hemoglobin is the protein in the blood that aids in carrying oxygen throughout the body. The ailment takes its appellation from the shape of the red blood cells of a person affected by Sickle Cell Disease, which have the shape of a sickle. They are stiff and adhesive rather than a disk like normal cells. The misshapen cells tend to get trapped in the small blood vessels hindering the movement of blood and oxygen to the many areas of one’s body. This causes pain and organ damage. Hemoglobin molecules are comprised of an alpha and a beta. People with Sickle Cell Disease have an aberration occurring on a gene in their chromosomes 11 and 16. ("Sickle Cell Disease.") Chromosome 11 is the “gene that codes for the beta subunit of the hemoglobin protein” ("Sickle Cell Disease.") This causes the particles in the hemoglobin not to manifest accurately.
This disease is a genetic disease and it is hereditary. It is inherited as an autosomal recessive disease. This means that in order to get the gene you must receive a recessive trait from your mother and your father. The parents could both be heterozygous for the trait and therefore not have the disease, but instead they would both be a carrier. There are only a few ways that the parents could possibly pass the trait. One possibility of having a child with sickle-cell disease is if both parents are heterozygous and they both pass on their recessive allele, (25% chance for offspring to have sickle-cell disease). Another possibility