A Review of Maryn McKenna’s Superbug: The Fatal Menace of MRSA When penicillin was released to the public in 1944, it was a miracle drug. Infections that had been killers were suddenly treatable. Doctors recommended it generously, both for illnesses that needed it and illnesses that didn’t. Before long, however, it took much stronger doses to see penicillin’s effects. When the antibiotic arms race began in 1944, most physicians assumed that new antibiotics would be discovered or created to keep up with the evolving resistance in bacteria, but the bacteria are constantly evolving new defenses and doctors are starting to run low on antibiotic ammunition. MRSA, methicillin-resistant Staphylococcus aureus, is one of many types of bacteria …show more content…
She begins with the discovery of the strain S. aureus phage type 80/81, a precursor to MRSA, in 1953, less than a decade after penicillin was released to the public. From there, she describes the emergence of MRSA strains first in hospitals and later in the general population. McKenna continues with the emergence and rise to dominance of the virulent and potentially deadly strain of USA 300. She includes the spread of MRSA to pets, pigs, and even an elephant. She additionally addresses the problems faced by schools and prisons in limiting MRSA’s spread. The history of MRSA includes over sixty years of outbreaks, discoveries, and setbacks. Superbug explicates this long and convoluted history so that it is both understandable and interesting to students interested in …show more content…
The main hospital strains are already partially or fully resistant to the effects of commonly used antibiotics. Resistance is also emerging to last resort drugs like vancomycin. The more virulent community strains of MRSA are infiltrating hospitals while the more resistant hospital strain is leaking into the community. The history of MRSA as described in Superbug shows how quickly bacteria can evolve when we add a strong selective force like antibiotics. Around the world, species of bacteria are becoming “superbugs” that are resistant to conventional treatments. Pharmaceutical companies are cutting research on new antibiotics in favor of more profitable investments. We are quickly running out of options for treating multi-drug resistant bacteria. As we move toward a “post-antibiotic” world, there are valuable lessons to be found in the history of MRSA, one of the first superbugs. Students in Emerging Diseases should read Superbug to learn about the complex emergence of
“Superbug” is the nickname given to the bacterium MRSA. It is called this because of its resistance to most antibiotics (1). Each year there are approximately 126,000 people hospitalized and 19,000
Some germs that commonly live on the skin and in the nose are called staphylococcus or "staph" bacteria. Usually staph bacteria don't cause any harm. However, sometimes they get inside the body through a break in the skin and cause an infection. These infections are usually treated with antibiotics. When common antibiotics don't kill the staph bacteria, it means the bacteria have become resistant to those antibiotics. This type of staph is called MRSA (Methicillin-Resistant Staphylococcus Aureus).
Methicillin-resistant Staphylococcus aureus, or more commonly, MRSA, is an emerging infectious disease affecting many people worldwide. MRSA, in particular, is a very interesting disease because although many people can be carriers of it, it generally only affects those with a depressed immune system; this is why it is so prevalent in places like nursing homes and hospitals. It can be spread though surgeries, artificial joints, tubing, and skin-to-skin contact. Although there is not one specific treatment of this disease, there are ways to test what antibiotics work best and sometimes antibiotics aren’t even necessary.
Methicillin Staphylococcus aureus is defined as strains of bacteria that are resistant to beta-lactam agents, including the synthetic penicillins (eg, methicillin, oxacillin) and the cephalosporins. MRSA can resist the effects of many common antibiotics, so it is difficult to treat. If the infection spreads to the blood stream and becomes systemic may increases risk for life threatening complications. First sign of MRSA are small red bumps that resemble pimples, boils or spider bites. Next they may mature into deep and painful abscesses that require surgical draining. If the bacteria is not confined to the skin and infect the blood stream, causing potentially fatal infections in bones, joints, surgical wounds, the bloodstream, heart valves and lungs.
Preventable infections regardless of the causative agent, have become major triggers of unintended patient outcome, increased morbidity, and mortality (Arias, 2010). Methicillin Sensitive Staphylococcus Aureus (MSSA) and Methicillin Resistant Staphylococcus Aureus (MRSA) are the most common causes of healthcare associated infections (HAI) and outbreaks in acute care hospitals and community settings (CADTH, 2010). The widespread infection with the MRSA pathogen is believed to have increased from 2.4 percent in 1975 to 29 percent in 1991 and 2003 in hospitals across the United States (U S) (CADTH, 2010). The prevalence is even greater among Intensive Care Unit (ICU) patients at 53 percent (CADTH, 2010) and continues to rise due to the widespread
Infections caused by antibiotic-resistant strains often occur in epidemic waves initiated by one or a few successful clones. Methicillin-resistant S. aureus (MRSA) is prominently featured during these epidemics. Historically associated with hospitals and other healthcare settings, MRSA now has emerged as a widespread cause of community infections. The majority of Staphylococcus aureus strains are now resistant to penicillin and methicillin (MRSA). Golden staph is creating headlines across the world, the superbug is becoming unstoppable. According to government statistics “one in five cases were resistant to antibiotics” (Alexander, 2017). Scientist are trying to eradicate golden staph with antibiotics, however they are adapting rapidly. Scientists are yet to identify how exactly the bacteria keeps adapting. Antibiotics attack infections by meddling with the bacterial ribosome, which is the part of the cell that makes proteins. If a cell cannot make protein, it dies. “The way the antibiotic works is it throws a spanner in the works. The drug comes in and jams up the machine so the cell can't make protein anymore. “Antibiotic-resistant bacteria find a way to apply oil and restart the machined Belousoff's team compared the cell structure of resistant and non-resistant strains of golden staph under an electron microscope to learn that the latter infections had developed a mutation several
MRSA (Methicillin Resistant Staphylococcus Aureus) is one of the most recent superbugs to become a health problem. MRSA is a species of Staphylococcus Aureus that is resistant to the antibiotic methicillin and antibiotics like it. Doctors are struggling to find proper treatment because of its resistance to the beta-lactam ring, the core of most antibiotics. The most lethal strain is the CC398 strain, most commonly found on livestock. There are approximately 80,000 invasive MRSA infections and 11,000 deaths every year. (CNN.com)
Historically MRSA infections have been confined to hospitals and infected those that generally were very sick to begin with. In recent years, MRSA has started to become prevalent in healthy individuals; specifically those on high school and collegiate sports teams. Studies have shown that the rates among athletes tend to be higher in contact sports like football and wrestling (Buss, 2014). The rates also seem to be higher than in the past due to the lack of policy regarding the infections and lack of people following through on the policies in place (Fritz, 2012). MRSA can be prevented for student athletes, especially if those around them are committed to doing what they can to protect the health of the students.
MRSA stands for Methicillin-resistant Staphylococcus aureus (MRSA) and is a bacterial infection that is highly resistant to some antibiotics. In short, antibiotics have been used since the 40's to stop the growth of bacteria. However, the more antibiotics are used, the quicker the bacteria become resistant to it while each year more types of bacteria adapt and become resistant to antibiotics. With MRSA being so resistant to many of the antibiotics, classifying it as a “super-bug”, it makes treatment of skin infections and invasive internal infections much more complicated. This leads to many yearly deaths. In fact, MRSA statistics show that more people die each year from MRSA infections than the
The article “The End of Antibiotics” discusses a 57 year old man that was dying and how doctors could only sit by while his condition deteriorated. This man was not shot or stabbed, he was infected with antibiotic resistant bacteria that was slowly killing him. He died months later after being bombarded with antibiotics in the form of capsules, tablets, and IVs (Begley par.1). This is the unsettling power that superbugs like this one has over modern day medicine. A superbug is a bacteria that has evolved its cellular structure to resist antibiotics. Dr. Richard Wenzel of the University of Iowa stated, “Only a few years after penicillin came into wide use with World War II, strains of staph had emerged
Methicillin-resistant staphylococcus also referred to as MRSA is a type bacterium that becomes immune to many antibiotics used to treat even the most common infection. MRSA has become an issue in hospitals around the globe as it is known to constanly change over time. Methicillin-resistant staphylococcus (MRSA) usually occurs in day care home, hospitals and other related health care facilities. It was reported that in 2005 the majority of all infection related cases came from an antibiotic-resistant bacterium, resulting in a high rate of death (Tacconelli, et al 2007). In 1961 (Enright, et al 2002) methicillin-resistant staphylococcus (MRSA) was first discovered in the United Kingdom and later made its way to Asia and after to the United States.
Methicillin resistant Staphylococcus aureus (MRSA) has been a type of multidrug resistant organism and staph bacteria known to cause serious infection that can lead to long hospitalizations and death. It can begin as a simple infection on skin or in the lungs, and if left untreated, can lead to traveling to the bloodstream and causing sepsis (“Methicillin-resistant Staphylococcus aureus (MRSA), 2015”). The Centers for Disease Control and Prevention reports that 33 percent of individuals carry the staph bacteria intranasally and two percent of individuals carry MRSA (“Methicillin-resistant Staphylococcus aureus (MRSA), 2015”). Even though this is a serious issue among healthcare settings all over the country, the number of people affected
It is undeniable that the recent discovery of antibiotics and disinfectants in the past century is leading to the creation of increasingly dangerous antibiotic-resistant bacteria. Super bugs like Methicillin-resistant Staphylococcus have begun breaking out in hospital areas, killing more and more patients due to the lack of people following through with simple safety measures. In order to stop the creation and spread of antibiotic-resistant super bugs, proper precautions must be taken such as avoiding antibacterial cleaners, following through with instructions when taking prescriptions and maintaining adequate hand hygiene. Through adhering to basic safety rules, the creation and spread of super bugs can be minimized and all together
Take for example MRSA (Methicillin-resistant Staphylococcus aureus), a S. aureus strain that was discovered in 1961 to be resistant to the antibiotic methicillin. Webmd indicates that MRSA has now grown its resistance from methicillin to “amoxicillin, penicillin, oxacillin and many other common antibiotics” (MRSA). This increase in resistance of a methicillin-resistant strain of S. aureus can be attributed to the increasing use and overuse of antibiotics, not only in the doctor’s office but also in agriculture. MRSA is only one of many antibiotic resistant strains of bacteria. New resistant strains are evolving rapidly. According to Dr. Ed Warren, “there are high levels of antibiotic resistance in bacteria causing common infections (e.g. urinary tract infections, pneumonia, bloodstream infections) in all regions of the world” (21).