Symptoms And Symptoms Of Sjogren Syndrome

1128 WordsFeb 3, 20165 Pages
Pulmonary histologic manifestation of Sjogren syndrome include nonspecific interstitial pneumonia , organizing pneumonia , usual interstitial pneumonia , lymphocytic interstitial pneumonia, primary pulmonary lymphoma , non caseating granuloma, bronchiolitis and diffuse interstitial amyloidosis. Acute fibrinous and organizing pneumonia (AFOP) is a histological pattern characterized by intra-alveolar fibrin deposition and associated organizing pneumonia. AFOP has been associated with rheumatologic disorders in the literature but has not been described in association with Sjogren’s syndrome. We present a case of a 75 year old female with history of Sjogren’s syndrome who was not compliant with her medications. She presented to our clinic…show more content…
The histological pattern are devoid of hyaline membrane, eosinophils, granulomatous inflammation or extensive pneumonia or abscess1. Other minor features include acute or chronic inflammation, type 2 pneumocyte hyperplasia and alveolar expansion with myxoid tissue1. This entity was first published by Beasley et al in 2002. The case of 17 patients showed male and Caucasian predominance with average age of 62 years. Average time to onset of symptoms was 19 days, and the most common symptoms includes cough, shortness of breath and constitutional symptoms like fatigue or malaise1. AFOP etiology could be idiopathic or due to a wide range of medical conditions including rheumatologic diseases like systemic lupus erythematous, ankylosing spondylitis, polymyositis, polymyalgia and juvenile dermatomyositis 1,2. Sjogren’s syndrome is a slowly progressive autoimmune disorder that affect many organ systems. Patients with Sjogren’s syndrome represent about 2 percent of the population and most commonly present with symptoms related to diminished lacrimal and salivary gland function 3. Pulmonary involvement in Sjogren’s syndrome is common. Histological pattern seen include nonspecific interstitial pneumonia , organizing pneumonia , usual interstitial pneumonia ,
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