The Cause Of Alzheimer's Disease

Even today, after so much study, Alzheimer’s is not fully understood. However, researchers do agree that this degenerative disease is caused by the gradual buildup of fibrous protein compounds in the brain, which are known in the scientific world as amyloids. These amyloids in the brain area act like plaque and as a result of their presence, the normal brain functioning is disrupted.

Throughout history there have been reports of decreased memory and mental deterioration that accompanied old age. Alzheimer’s disease (AD) was named after Dr. Alois Alzheimer who described the symptoms in a woman in Germany in the 1907 but it was not until the 1970’s that AD was considered to be a major disorder and AD continues to be a major health concern worldwide (Reger, 2002).

According to Lu and Bludau (2011), Alzheimer disease is a degenerative disease of the brain that can lead to dementia and impair all brain functioning. Biologically, Alzheimer’s disease is believed to be caused by abnormal plaques called amyloid plaques, which are a buildup of protein fragments that are thought to be damaging to the brain cells. However, scientists are still unsure if this buildup actually cause the disease or is a result of the disease itself. This disease can also be a result of a genetic mutation, increasing individuals with the gene mutation risk as much as eight times higher than individuals

In general terms, Alzheimer is a word that is used to discuss the condition where an individual undergoes the decline in their mental ability to an extent where they start forgetting about things. In a layman’s language, it involves times and occasions when the patient loses their memory and also face the difficulty to carry the basic steps during the daily routines, like carrying out solving or thinking about general concerns in life. In all conditions and types of the issue dementia, Alzheimer’s in dementia is known as the most common condition that leads to memory loss (Dennis, 2005).

Alzheimer’s disease is incurable, but there are many stages, warning signs, and risk factors that can serve as detection devices for those who have older adults in their lives. One of the most common early signs of this form of dementia is memory loss. While it is normal for people to occasionally forget things, such as appointments and names, people with Alzheimer’s tend to forget these things more often and are not able to recall them even after a period of time. Other signs that signify a possible case of Alzheimer’s is difficulty performing familiar tasks (cooking, brushing teeth), problems with language (using odd words, failing to remember correct words), disorientation (forgetting where one lives, not knowing how he got to a certain place), problems with abstract thinking (forgetting what numbers represent), misplacing items (putting a hair brush in the freezer), moodiness, personality changes (confusion, suspicion, fearfulness), and loss of initiative

“Alzheimer’s Disease (AD) is a type of dementia, which is affecting the population that develops in the brain and can lead to problems with memory, thinking and behavior”. The Amyloid Hypothesis claims that the build up of the beta-amyloid in the brain is a cause in the development of Alzheimer disease in patients. This plaque of the beta-amyloid and its cascade of events can be linked to the deterioration and negative effects of cognitive function of the brain over time. The beta-amyloid is described to be a “sticky” protein located in the brain therefore plaques or build up of the amyloid is common. These plaques in turn can block the brain cells from communicating with each other. Which then activates an immune system, that leads to inflammation

More than five million are living with Alzheimer’s disease in the United States and the number is set to almost triple by the year 2050. It is common in the elderly and generally occurs in persons over 65 years of age, but early onset of Alzheimer’s has also been documented (“Alzheimer’s disease facts,” 2016, para. 1). It starts in the medial temporal area of the brain, usually in the hippocampus, and then spreads to other areas of the brain. Blows (2011) explains, “Alois Alzheimer was a German psychiatrist who in 1906 described a dementia with two specific changes found in the brain after death... these changes were the presence of extracellular plaques and intracellular neurofibrillary tangles and these became the hallmarks of this disease” (p. 286). Loss of neurons takes place and amyloid plaques form. This is due to build-up of non-functioning proteins and can be observed by imaging techniques (Radin, 2003, p. 41). There are many risk factors that increase the risk of Alzheimer’s disease. The greatest risk factor is family history, but other risk factors include diabetes, hypertension obesity, hyperlipidemia, smoking, depression, physical inactivity, low estrogen levels, and head trauma (Huether & McCance, 2014, p. 546). The actual cause of Alzheimer’s is unknown, but there are genes associated with it that make the disease heritable. What is clear is that

Don’t forget what you want to know, and know what you don’t want to forget. Alzheimer’s Disease does not give people this option. Alzheimer’s tears families apart, takes loved ones away, and makes them forget who you are. Imagine hearing your grandmother, a woman who lived through some of America’s most exciting periods, and who completed a successful career before you were born, saying with total belief, “Did you hear my mother just died.” Imagine having your father tell you that your grandmother probably doesn’t know who you are. Imagine your grandmother, who traveled an hour every week for years to play with you, meeting you with a blank stare.

Alzheimer’s Dementia has seven stages. Stage one is no impairment or normal function. Stage two is very mild cognitive decline. This stage can be the earliest signs of Alzheimer’s or age-related changes such as forgetfulness. Stage three is mild cognitive decline. This is when doctors can diagnose the beginnings of Alzheimer’s. Common stage three difficulties include trouble remembering names, greater difficulty completing or staying on task, and increased trouble with organizing and planning. Stage four is moderate cognitive decline. Symptoms in this stage become more clear such as forgetting recent events, becoming moody or withdrawn, and greater ability to perform complex tasks. Stage five is moderately severe cognitive decline or mid-stage Alzheimer’s. During this stage the patient may not be able to remember his or her address or telephone number and become confused about where he or she is and what day it is. The patient will still be able remember significant details about his or her family and past. Stage six is severe cognitive decline. During this stage memory continues to worsen and personality changes may begin to take place. This stage also includes wandering, changes in sleep patterns, incontinence, and remembering names of family members. The final stage is seven: very severe decline or late-stage Alzheimer’s. In this final stage the patient will lose his or her ability to respond, have a

First described by German physician, Alois Alzheimer, in the early 1900s, Alzheimer’s disease is now the fourth most prevalent cause of death- after heart disease, cancer, and stroke (AD- a guide for families). Most common in adults 65 or older, Alzheimer’s disease (AD) is regarded as “a loss of intellectual abilities sufficient enough to interfere with everyday social and occupational functioning” (AD- a guide for families). Victims of AD are unable to think abstractly, find similarities and differences between related words, and have trouble defining words and concepts. Other common symptoms include disturbances in language, or aphasia, an inability to carry out motor activities, or apraxia, and a failure to recozinge or identify

Damage or lesions to the brain are the main causes of Alzheimer’s disease; the two main causes of these lesions are neurofibrillary tangles and senile plaques. (4) These are commonly known as plaques and tangles and are caused by the build-up of two proteins. The plaques are a build-up of the protein beta-amyloid (β-amyloid) while the tangles are formed by the build-up of the protein tau, even though both are found in Alzheimer's disease only the β-amyloid plaques are unique to the disease and it is these plaques that are believed to be the primary cause of Alzheimer's.

Alzheimer’s is a type of dementia that causes complications with memory, thinking, and behavior. Long before any signs of memory loss, there a microscopic changes occurring in the brain, altering its functionality (Alzheimer 's Association Organization, 2016). The brain has billions of nerve cells that work together, and when one portion of the brains neurons are malfunctioning it leads to breakdowns in other parts of the brain. The two most noted abnormal structures that are suspected to damage and kill neurons in the brain in patients with Alzheimer’s are plaques and tangles. Plaques are deposits of a proteins fragment called beta-amyloid that build up in the spaces between nerve cells; and tangles are twisted fibers of another protein called tau that build up inside cells (Alzheimer 's Association Organization, 2016).

There have been said to be ten major signs and symptoms that indicate the early onset of Alzheimer’s disease. Memory loss that disrupts daily life, Challenges in planning or solving problems such as not being able to keep track of monthly bills. Difficulty doing simple task at home, work, or leisure. Confusion with time or place may be a warning sign. Trouble understanding visual images and spatial relationships such as having difficulty reading. Misplacing things are unable to retrace steps. Poor judgement is also an indicator of this disease. Withdraw from work or social activities. Then changes in mood and personality such depression, anxiety, and confusion. Alzheimer’s Association (2015) Know the Early Signs, Early Detection Matters.

Imagine greeting your grandmother and being met with a blank stare. Think about how it would feel to watch as your father forgets how to drive or dress himself. Picture your own mother crying out for her long dead parents and siblings. Try to envision the look on a loved one’s face as you tell them that they can no longer live at home alone. Now put yourself in their place-- slowly losing your freedom, your memory, and your very identity. Welcome to the world of Alzheimer’s disease. This is the reality that nearly fifteen million caregivers and over five million patients must face every day. Public awareness must be raised about Alzheimer’s disease and the people it affects.

While scientists are still working on understanding the details of Alzheimer’s, they do know that the disease involves the build up of plaque and tangles in between neurons that interfere with cell signaling and cause the death of these cells. Plaques are made of a protein called beta amyloid, which is a