The Cause Of Huntington's Disease

Huntington’s Disease is a brain disorder affecting movement, cognition, and emotions (Schoenstadt). It is a genetic disorder generally affecting people in their middle 30s and 40s (Sheth). Worldwide, Huntington’s disease (affects between 3-7 per 100,000 people of European ancestry (Schoenstadt). In the United States alone, 1 in every 30,000 people has Huntington’s disease (Genetic Learning Center). Huntington’s Disease is a multi-faceted disease, with a complex inheritance pattern and a wide range of symptoms. There is also much research being done in the field of Huntington’s disease, because as of 2012, this disease is untreatable. THESIS.

Huntington's Disease is a genetic autosomal disorder which effects the brain. It affects about 1 in 20,000 individuals. The symptoms of the disease do not start to occur until after or around 40 years of age. With the onset of the disease the patient starts to gradually deteriorate intellectually, this deterioration also causes involuntary movements. Scientists have only recently found the section of the gene which causes Huntington's disease, and this is allowed them to devise pre-symptomatic tests. However, a cure for the disease is yet to be found.

Huntington's Disease (HD) is an autosomal dominant, progressive, neurodegenerative disorder (Walker, 2007 and Harmon, 2007). The gene that causes the disease is located on the fourth chromosome and causes an abnormal number of repeats in the patient's genetic code (Harmon, 2007). Huntington's Disease can have devastating effects on patients' quality of life. The first symptoms of HD generally start between the ages of 30 and 45 and patients are typically asymptomatic prior to this time (Terrenoire, 1992 and Walker, 2007). However, the disease progresses with subtle changes in motor control, personality, and cognition. Patients eventually develop distinct

Huntington’s disease is a degenerative neurological disorder affecting movement, cognition, and emotional state (Schoenstadt). There are two forms of Huntington’s disease (Sheth). The most common is adult-onset Huntington’s disease, with persons usually developing symptoms in their middle 30s and 40s (Sheth). There is an early onset form of Huntington’s disease, beginning in childhood or adolescence, and makes up a small percentage of the Huntington’s population (Sheth). Huntington’s disease is a genetic disorder with a short history, a plethora of symptoms, and devastating consequences, with no current cure in sight.

Huntington’s disease may be irreversible but it can be treated with proper treatment may slow down the effects of the disease and medical attention. In children who have symptoms of Huntington’s disease, some of the symptoms would be a rapid deteriorating in school performance, lack of swift movements, behavior changes etc...

Huntington's disease is an inherited genetic disease which can’t be cured. (Staff, M. C , 2014) Huntington's disease is caused by an inherited defect in a single gene. A parent with a defective Huntington gene could pass along the defective copy of the gene or the healthy copy. Each child in the family, therefore, has a 50 percent chance of inheriting the gene that causes the genetic disorder.Huntington’s disease has a broad impact on a patients’ functional abilities and thinking and psychiatric disorders. They get involuntary jerking or writing movements (chorea), have difficulty organizing tasks and learning new things. (Staff, M. C , 2014) Patients act like the girl in Andersen’s fairy tales

Huntington's disease is an autosomal dominant disorder, which is found on the # 4 chromosome. George Huntington discovered it in 1872. It mainly has an effect on the nervous system. There are around 210,000 bases between D4S180 and D4S127. The disease itself is found in 2% of people in their childhood, and in 5% of the people they were older then 60. (Miller p 16) In the majority of the affected people the disease is detected between the ages of 35-45. In males the disease begins around the time of their childhood. However, in females it begins later in life. This severe symptom has a tendency for the condition to worsen as it is passed on from generation to generation. Huntington’s disease is paternally

It is caused by the same mutated gene, but many juvenile Huntington's Disease cases have shown that well over 40 CAG may be the cause of such early development. Earlier appearance of symptoms leads to faster progression of the disease. Beginning signs include decline in school performance, and seizures may follow. Likewise to adult onset Huntington’s Disease, depression can result from the decline in functionalities. However, many early onset Huntington’s Disease can also lead to different symptoms, such as rigidity or

Huntington’s disease is a hereditary disorder that affects a person’s nervous system and kills brain cells. It is caused by a defective gene on chromosome four, which is one of the chromosomes that holds our genetic code. This disease has been known to cause problems with the body’s abilities to produce energy from nutrients taken in from the body. Patients that have more advanced stages of Huntington’s Disease commonly experience increased weight loss.

Huntington’s disease is a neurological (nervous system) condition caused by the inheritance of an altered gene. A neurological disorder is a disease that can affect the central and peripheral nervous systems. Huntington’s disease is an incurable genetic brain disorder. The disease is an autosomal dominant disease, meaning a child only needs to inherit the gene from one parent to develop Huntington’s. Nerve cells become damaged when someone holds the HTT gene that produces a protein called huntingtin, as too much of this protein damages cells, and causes various parts of the brain to gradually deteriorate. Huntington’s disease causes changes in the central area of the brain, the basal ganglia, which can affect movement, emotions, and mental

Huntington’s Disease is a genetic disease that causes gradual brain deterioration in a wide range of ages. Early onset conditions can occur in an individual younger than twenty and some late onset conditions can develop as late as 80. Early symptoms are subtle, such as emotional changes, as time goes on symptoms worsen to memory loss and loss of cognitive functions, then there is complete loss of the body. In most cases, death occurs for related complications such as pneumonia, infections, falls, and inability to swallow within ten to twenty years of symptom appearance. If someone has Huntington’s Disease, there isn’t anything to prevent brain deterioration. Even If someone without symptoms is tested and predicted HD(Huntington's Disease),

Huntington Disease is a rare inherited Neurological illness. This illness is passed down from generation, but may not show up until you are an adult and is may no never show up. It often appears in more than one member if it occurs in a family. This a Genetic Condition. The change in the genetic information that is passed down is what causes Huntington's Disease. This illness causes involuntary movements, severe emotional disturbance. Huntington causes parts of the brain to break down and lose some natural functions and affects the Nervous system. The very first noticeable symptoms of this illness in changes in personality and muscle twitches. You would usually start to notice these symptoms around the age of 30 to 50. The men and women with

The Huntington disease is a type of disease people suffer when they gradually got older, around 30 to 40 years old. It provides instructions for making proteins. The function is unknown, although it plays an important role in the nerves cells, in the brain. HTT mutation causes the Huntington disease and involves a DNA segment known as a CAG trinucleotide. Unfortunately there is no cure for the disease but drugs, physiotherapy and talk therapy can help manage some symptoms.

Huntington’s Disease (HD) is a late-onset, chronic neurodegenerative disease characterized by impairments in motor, cognitive, and psychological functions. It is caused by a mutation in Exon 1 of the IT15 gene, which encodes the huntingtin (Htt) protein. Mutant huntingtin (mHtt) has an expanded CAG repeat in its N-terminal region, encoding a poly-glutamine (polyQ) track that can either form toxic aggregates in neurons or interact with various cellular proteins, leading to altered cellular processes and neuronal apoptosis. In HD, the loss of inhibitory medium spiny neurons within the striatum causes involuntary movements characteristic of the disease; These neurons are involved in refining the excitatory outputs of the cerebral cortex, which

The Huntington disease is a condition inherited in an autosomal, dominant pattern, meaning one copy of the altered gene in each cell, sufficient to cause this disorder. The affected person inherits the altered gene from the affected parent. HTT gene is passed from generation to generation and when the CAG trinucleotide repeats over time, it increases in size. People with adult-onset with the form of the Huntington disease have around 40-50 CAG repeats in a HTT gene. People with a juvenile form of disorder have more than 60 CAG repeats, whilst an individual person have around 27-35 CAG repeats in a HTT gene which cannot develop the Huntington disease but have the risk of having children who will develop this disorder.