The Clinical, Serologic And Genetic Models

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pCD. The clinical, serologic and genetic models were studied individually as well as in combination to identify the model with the highest AUC.

Baseline Characteristics
One thousand seven hundred and twenty one CD patients were identified with mean disease duration of 10.2 years (range, 4 months – 51.5 years). Nine hundred and twenty six (53.8%) patients were male (Table. 1). A majority of patients were Caucasian (93.1%) and 39% of the Caucasian patients were Jewish.
Perianal Crohn’s disease was identified in 524 patients (30.4%), constituting approximately one-third of the study cohort. When Montreal disease classification was applied; more than half the patients (54.2%) exhibited complicated disease behavior; characterized by
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A family history of IBD among first-degree relatives (OR 4.98 [3.30-7.46]; p <0.001) was also associated with pCD, suggesting additional hereditary influences in the development of pCD. Isolated small bowel disease conferred a protective effect on the development of pCD (OR 0.38 [0.28-0.52]; p <0.001) whereas colonic involvement was significantly associated with pCD (OR 1.35[1.04-1.75]; p = 0.03). To further clarify the association between pCD and colonic and small bowel disease, we identified patients with any colonic or any small bowel disease and observed the same pattern of a protective effect with any small bowel disease (OR 0.74 [0.57-0.96]; p =0.03) and a significant association with any colonic disease (OR 2.55 [1.89-3.49]; p < 0.001) for the presence of pCD. Within the colon, distal colonic inflammation showed a strong association with pCD (Table. 3) with a higher OR for pCD the more distal the site of disease involvement.
Patients with non-stricturing and non-penetrating behavior were less likely to develop pCD (OR 0.69 [0.56-0.85]; p = 0.001); whereas stricturing disease behavior was associated with pCD (OR 1.44[1.14-1.81]; p = 0.002). We did not find an association between internal penetrating disease and pCD (Table 3). There was a statistically significant association between pCD and dermatologic manifestations of CD, namely pyoderma gangrenosum and erythema nodosum (OR 2.03 [1.33-3.09]; P=
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