The cumulative prognosis time distribution for the selected signaling pathways are shown in Fig. 4. The later activation of the IL-10 pathway in the symptomatic subjects can be explained by the anti-inflammatory nature of IL-10 and…. Similarly, the fact that the DNA sensing pathway is quick to become anomalous is likely due to the initial detection of viral ssRNA by RIG-I (Pichlmair, et al., 2006). In fig. 5, we show further evidence of the pathway cascade, i.e., the fraction of the subjects that have k pathways out of 403 that are in alarm at a given time averaged over all symptomatic subjects. This graph suggests that the pathway cascade could permit a potentially very early diagnosis of influenza. For example, these results suggest that at least 25% of patients that become symptomatic could be identified in the first 16 hours of infection using a five alarm pathway. Discussion of pathway results The most likely pathway to go into alarm first in our experiment, based on the MSET results, was the cytosolic DNA sensing pathway. It was the first pathway to alarm in the cascade over 70% of the time. Influenza A does not generate dsDNA, but negative sense ssRNA (Pichlmair, et al., 2006). The cytosolic DNA sensing pathway is known to detect foreign dsDNA in the cell and upon detection of this exogenous DNA, production and maturation of cytokines and interferons initiates an immune response (http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04623). However, ssRNA can
According to Center for Disease Control (CDC), influenza viruses are divided into three types, designated as A, B, and C. Influenza type C usually only causes either very mild symptoms or no symptoms at all. Types A and B, however, are responsible for epidemics of respiratory illnesses that can result in hospitalization, or even death. Influenza is constantly changing over time by mutations. This continual change allows the virus to evade the antibodies that were meant to kill it. A host infected with influenza virus develops antibodies against that virus; as the virus changes, the "first" antibody no longer recognizes the "newer" virus and infection can occur because the host does not recognize the new flu virus as a problem until the infection is well under way. The first antibody developed may, in some instances, provide partial protection against infection with a new influenza virus. According to Medicine Net.com, In 2009, almost all individuals had no antibodies that could recognize the novel H1N1 virus immediately. It quickly spread throughout the world so fast that the WHO declared this new flu strain (termed novel H1N1 influenza A swine flu). There are currently four main strains of influenza circulating worldwide. Three of the viruses are type A, and one is type B. Type A viruses are divided into subtypes based on the differences in two viral proteins called hemagglutinin (H) and neuraminidase (N). The three subtypes of influenza A are A(H1N1), A(H3N2), and A(H5N1). The reason for several strands of type A are because of the two kinds of change influenza A
For long before the 1918 pandemic, doctors had been trying to isolate the microorganism that causes influenza. In 1892, one man, Dr. Friedrich Johann Pfeiffer, believed he had the answer. His discovery, Pfeiffer’s
Every year, millions of people start talking about the influenza virus and getting their vaccines as the flu season approaches, which starts around the October-November period and reaches its peak between December and March. Therefore, public health officials around the world- and in the U.S in particular- are constantly challenged by properly preparing for the annual influenza dilemma, given that this viruses, and other respiratory viruses, are a serious health threat to the U.S population and the world as a whole. Furthermore, what makes the influenza virus even more challenging to control is that it can mutate rapidly and reassort to form new strains, having the ability to reside in multiple animal hosts. In fact, many scientists and researchers have been doing in-depth intensive research so as to understand the mechanism behind this unique characteristic of the virus, try to find new ways to control it, and explore different areas of protection and vaccination.
The epidemilogic triangle describes the relationships and interactions among the infectious agent, the host, and
This new influenza baffled researchers and doctors everywhere. Up to this point, all viral diseases has spread prominently throughout heavily populated areas and into the lungs of the very young, very old, or sickly. On the contrary, the Influenza of 1918 swept through the Midwest and preyed on the
According to the Centers for Disease Control and Prevention (CDC, 2013) national healthcare disparities report for 2010, influenza and pneumonia are ranked within the top ten major causes of death in the United States. The influenza viruses that will be discussed throughout this case study include the human influenza viruses: A and B. These viruses are responsible for seasonal epidemics during the fall and winter around the globe in temperate environments. Historically influenza outbreaks have had a seasonal distribution and characteristic time course although according to the CDC (2017) factors influencing the extent and severity of an outbreak are less clear. Generally, there are two or three different influenza strains typically circulating concurrently in any given
Influenza, an innocent little virus that annually comes and goes, has always been a part of people’s lives. Knowing this, one would not believe that it has caused not one, not two, but three pandemics and is on its way to causing a fourth! The Spanish flu of 1918, the Asian flu of 1957, and the Hong Kong
There are there types of influenza A and C or the most severe types and B which is the most common, Luckily not the to severe. The virus works by first attaching to the outside of a host cell. It injects its RNA into the cell. Unfortunately our cells treat the RNA like they should. It translates the viral genes using the cell’s ribosomes and enzymes. Now the virus can take the cell over and use it to reproduce more viruses. Sooner or later it releases the new nauseating viruses and they search for another cell to raid.
Avian influenza is a disease that has been wreaking havoc on human populations since the 16th century. With the recent outbreak in 1997 of a new H5N1 avian flu subtype, the world has begun preparing for a pandemic by looking upon its past affects. In the 20th Century, the world witnessed three pandemics in the years of 1918, 1957, and 1968. In 1918 no vaccine, antibiotic, or clear recognition of the disease was known. Killing over 40 million in less than a year, the H1N1 strain ingrained a deep and lasting fear of the virus throughout the world. Though 1957 and 1968 brought on milder pandemics, they still killed an estimated 3 million people and presented a new
In the first place, influenza is caused by influenza virus (Infectious Diseases). According to Mortada, there are three types of viruses, A, B, and C and the virus
Extemporaneous Writing Impact of Influenza on Society Influenza is a virus that infects the upper respiratory system. The common symptoms include but are not limited to: coughing, sneezing, and drowsiness. Influenza is spread by droplets of water or other substances containing the virus landing on another being after an infected person coughs or sneezes. The person who then contracts the disease could take anywhere from 1-4 days to show symptoms.
Most influenza outbreaks disproportionately kill juvenile, elderly, or already weakened patients; in contrast the 1918 pandemic predominantly killed previously healthy young adults. Modern research, using virus taken from the bodies of frozen victims, has concluded that the virus kills through a cytokine
Each year in the United States, 3000–49,000 influenza associated deaths occur, with over 90% reported among older adults aged 65 years or older. Influenza also results in an estimated 226,000 hospitalizations, with hospitalization rates among older adults increasing over the past 2 decades (Nace et al., 2015). Influenza is a highly transmissible viral illness that may lead to severe complications from underlying diseases, primary viral or secondary bacterial pneumonia and death (NCBI, 2015). Immunization is one of the most powerful and cost effective interventions against
Influenza is a virus that is transmitted mainly via airborne process, which is one of the fastest mode of transmission. It is transmitted though airborne due to symptoms such as coughing and sneezing of the host (the infected). The host sneezes and coughs, influenza can easily be transmitted the agent via droplets and small microorganism, therefore entering the uninfected though the respiratory system (mouth and nasal) (WHO, 2016). Another way the virus can lead to pandemic, is due to the fact that the number of human and animals continue to grow and interact. Thus, the pandemic of influenza type A is possible. This mode of transmission is both and; the airborne (respiratory system) and physically (hand contamination). The customarily begins in rural areas (farms) as the virus can be found in hosts such as horses, pigs, chickens and birds. There has been an undetected interchange of the disease among animals and humans in rural environments which then eventually grows to become a global pandemic (Webster, RG & Monto, AS et al 2013, Textbook of influenza). The virus may continue to spread physically due to hand contamination in public; these may include door handles, public transport and other hand held hold objects. The last mode of transmission is genetically, this may then lead to asthma or even death (WHO,
Background & Audience Relevance: Influenza is an infection that can affect anyone around the world. Am quite sure almost everyone, if not all of us, have been infected with influenza at some point in our lives.