The cumulative prognosis time distribution for the selected signaling pathways are shown in Fig. 4. The later activation of the IL-10 pathway in the symptomatic subjects can be explained by the anti-inflammatory nature of IL-10 and…. Similarly, the fact that the DNA sensing pathway is quick to become anomalous is likely due to the initial detection of viral ssRNA by RIG-I (Pichlmair, et al., 2006). In fig. 5, we show further evidence of the pathway cascade, i.e., the fraction of the subjects that have k pathways out of 403 that are in alarm at a given time averaged over all symptomatic subjects. This graph suggests that the pathway cascade could permit a potentially very early diagnosis of influenza. For example, these results suggest that at least 25% of patients that become symptomatic could be identified in the first 16 hours of infection using a five alarm pathway. Discussion of pathway results The most likely pathway to go into alarm first in our experiment, based on the MSET results, was the cytosolic DNA sensing pathway. It was the first pathway to alarm in the cascade over 70% of the time. Influenza A does not generate dsDNA, but negative sense ssRNA (Pichlmair, et al., 2006). The cytosolic DNA sensing pathway is known to detect foreign dsDNA in the cell and upon detection of this exogenous DNA, production and maturation of cytokines and interferons initiates an immune response (http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04623). However, ssRNA can
According to the Centers for Disease Control and Prevention (CDC, 2013) national healthcare disparities report for 2010, influenza and pneumonia are ranked within the top ten major causes of death in the United States. The influenza viruses that will be discussed throughout this case study include the human influenza viruses: A and B. These viruses are responsible for seasonal epidemics during the fall and winter around the globe in temperate environments. Historically influenza outbreaks have had a seasonal distribution and characteristic time course although according to the CDC (2017) factors influencing the extent and severity of an outbreak are less clear. Generally, there are two or three different influenza strains typically circulating concurrently in any given
Ishmael Beah, the author of the memoir A Long Way Gone, is a twelve-year old boy who is trapped inside a war zone in Sierra Leone, Africa. When his home town, Mattru Jong is attacked by “the rebels,” he is separated from his family and is forced to run from everything he once loved. Ishmael flees from town to town with other teenagers who face the same problems, trying to survive and escaping attacks from villagers. Beah writes, “People were terrified of boys our age. Some had heard rumors about young boys being forced by rebels to kill their families and burn their villages,” (Beah 37). At such a young age Ishmael was trying to survive off of what he had; sometimes he went days without food. Ishmael was deprived of more than just his clothing.
Peer pressure could come from a series of people. In many cases adults pressure children to act, dress, and submit to different situations in life. Salvation by Langston Hughes brings forth a very relatable topic to the reader’s eyes.The author’s purpose of Salvation is strictly to bring light to the role adults play in children's decision making. In other words the author expressed a time he was pressured to believe and do as adults say and he also dicuss the negative affect being pressured had on his
The epidemilogic triangle describes the relationships and interactions among the infectious agent, the host, and
This new influenza baffled researchers and doctors everywhere. Up to this point, all viral diseases has spread prominently throughout heavily populated areas and into the lungs of the very young, very old, or sickly. On the contrary, the Influenza of 1918 swept through the Midwest and preyed on the
Every year, millions of people start talking about the influenza virus and getting their vaccines as the flu season approaches, which starts around the October-November period and reaches its peak between December and March. Therefore, public health officials around the world- and in the U.S in particular- are constantly challenged by properly preparing for the annual influenza dilemma, given that this viruses, and other respiratory viruses, are a serious health threat to the U.S population and the world as a whole. Furthermore, what makes the influenza virus even more challenging to control is that it can mutate rapidly and reassort to form new strains, having the ability to reside in multiple animal hosts. In fact, many scientists and researchers have been doing in-depth intensive research so as to understand the mechanism behind this unique characteristic of the virus, try to find new ways to control it, and explore different areas of protection and vaccination.
Influenza, an innocent little virus that annually comes and goes, has always been a part of people’s lives. Knowing this, one would not believe that it has caused not one, not two, but three pandemics and is on its way to causing a fourth! The Spanish flu of 1918, the Asian flu of 1957, and the Hong Kong
Avian influenza is a disease that has been wreaking havoc on human populations since the 16th century. With the recent outbreak in 1997 of a new H5N1 avian flu subtype, the world has begun preparing for a pandemic by looking upon its past affects. In the 20th Century, the world witnessed three pandemics in the years of 1918, 1957, and 1968. In 1918 no vaccine, antibiotic, or clear recognition of the disease was known. Killing over 40 million in less than a year, the H1N1 strain ingrained a deep and lasting fear of the virus throughout the world. Though 1957 and 1968 brought on milder pandemics, they still killed an estimated 3 million people and presented a new
For long before the 1918 pandemic, doctors had been trying to isolate the microorganism that causes influenza. In 1892, one man, Dr. Friedrich Johann Pfeiffer, believed he had the answer. His discovery, Pfeiffer’s
Extemporaneous Writing Impact of Influenza on Society Influenza is a virus that infects the upper respiratory system. The common symptoms include but are not limited to: coughing, sneezing, and drowsiness. Influenza is spread by droplets of water or other substances containing the virus landing on another being after an infected person coughs or sneezes. The person who then contracts the disease could take anywhere from 1-4 days to show symptoms.
There are there types of influenza A and C or the most severe types and B which is the most common, Luckily not the to severe. The virus works by first attaching to the outside of a host cell. It injects its RNA into the cell. Unfortunately our cells treat the RNA like they should. It translates the viral genes using the cell’s ribosomes and enzymes. Now the virus can take the cell over and use it to reproduce more viruses. Sooner or later it releases the new nauseating viruses and they search for another cell to raid.
Each year in the United States, 3000–49,000 influenza associated deaths occur, with over 90% reported among older adults aged 65 years or older. Influenza also results in an estimated 226,000 hospitalizations, with hospitalization rates among older adults increasing over the past 2 decades (Nace et al., 2015). Influenza is a highly transmissible viral illness that may lead to severe complications from underlying diseases, primary viral or secondary bacterial pneumonia and death (NCBI, 2015). Immunization is one of the most powerful and cost effective interventions against
Background & Audience Relevance: Influenza is an infection that can affect anyone around the world. Am quite sure almost everyone, if not all of us, have been infected with influenza at some point in our lives.
Influenza is a virus that is transmitted mainly via airborne process, which is one of the fastest mode of transmission. It is transmitted though airborne due to symptoms such as coughing and sneezing of the host (the infected). The host sneezes and coughs, influenza can easily be transmitted the agent via droplets and small microorganism, therefore entering the uninfected though the respiratory system (mouth and nasal) (WHO, 2016). Another way the virus can lead to pandemic, is due to the fact that the number of human and animals continue to grow and interact. Thus, the pandemic of influenza type A is possible. This mode of transmission is both and; the airborne (respiratory system) and physically (hand contamination). The customarily begins in rural areas (farms) as the virus can be found in hosts such as horses, pigs, chickens and birds. There has been an undetected interchange of the disease among animals and humans in rural environments which then eventually grows to become a global pandemic (Webster, RG & Monto, AS et al 2013, Textbook of influenza). The virus may continue to spread physically due to hand contamination in public; these may include door handles, public transport and other hand held hold objects. The last mode of transmission is genetically, this may then lead to asthma or even death (WHO,
Until the last decade, environmental and sustainability concerns were not considered to be caused by banks. This was because showing concern for the environmentally degrading activities of their