The Effect Of Two Drugs On The Human Being, Aceclofenac And Eperisone Hydrochloride

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This study is a clear example of a clinical trial. The objective is analyzing the possible interactions between two drugs in the human being, Aceclofenac and Eperisone Hydrochloride. Aceclofenac has demonstrated to be potential analgesic and anti-inflammatory drug with same activity that indomethacin and diclofenac, and due to its preferential Cox-2 blockade, it is more safe than traditional Non-steroidal anti-inflammatory drug (NSAIDs) regarding to adverse effect on gastrointestinal and cardiovascular systems. Aceclofenac has selectivity for Cox-2, what makes it stands among others NAIDs. This favorable Cox inhibitor is well tolerated; it is Gastrointestinal (GI) tolerable and safe for cardiovascular system when compared with other selective Cox-2 inhibitor (Solanki et al, 2015). Eperisone hydrochloride is a muscle relaxant acting in central nervous system, through poly and mono-synaptic reflexes in the spinal cord, shows vasodilator effect, rises blood flow and blocks the pain reflex pathway. It has been presented to be beneficial for treatment of various myotonic conditions (Chandanwale et al, 2011). Both drugs has been shown efficacy in treatments, they are the most used NAIDs and muscle relaxant in Korea actually. The combination of the drugs is often prescribed to treat muscle spasms pain. The present study aims to analyze from a group of healthy Korean men whether these drugs will cause adverse reactions with concomitant use of single-dose. Participants and
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