The Efficacy And Metabolic Profile Of Bipolar Disorder

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A Systematic Review of the Efficacy and Metabolic Profile of Lurasidone in the Treatment of Depression in Bipolar Disorder MSc in Psychiatry 2015 Dissertation by Giles Osborne BA BSc MA(Oxon) Department of Psychiatry, Cardiff Medical School, Cardiff, CF14 4XN Main Body Word Count 18,885 May 2015 DECLARATION / STATEMENTS PAGE DECLARATION This work has not previously been accepted in substance for any degree and is not concurrently submitted in candidature for any degree. Signed----------------------------- (G R Osborne) Date---------------------------------------- STATEMENT 1 This thesis is being submitted in partial fulfilment of the requirements for the degree of MSc (Psychiatry) Signed---------------------------- (G R …show more content…

Signed--------------------------- (G R Osborne) Date----------------------------------- ACKNOWLEDGEMENTS I would like to thank Mr Jon Ford BSc MSc and Dr Chris Lee MBBS PhD for the proofreading of this paper. I would particularly like to thank Dr Chris Lee for inspiring me to undertake this MSc. Dedicated to Obi, even though he may not have the cognitive construct of self. ABBREVIATIONS ADL: Activities of Daily Living AE: Adverse Event ANCOVA: Analysis of Covariance ANOVA: Analysis of Variance BDNF: Brain Derived Neurotrophic Factor BMI: Body Mass Index BPD: Bipolar Disorder CGI-BP: Clinical Global Impressions Scale CGI-BP-C: Clinical Global Impressions Scale - Bipolar-Change Scale CGI-BP-S: Clinical Global Impressions Scale - Bipolar-Severity Scale CI: Confidence Interval CVD: Cardiovascular Disease DB: Database df: Degrees of Freedom DSM IV/ 5: Diagnostic and Statistical Manual of Mental Disorders versions 4 or 5 EMA: European Medicines Agency EPSE: Extrapyramidal Side Effects EU: European Union FPG: Fasting Plasma Glucose FDA: Food and Drug Administration FDC: Fixed Dose Combination GLP: Good Laboratory Practice HAM-D: Hamilton Depression Rating Scale HR: Hazard Ratio ICD 10: International Classification of Diseases 10th Revision ICH-GCP: International Conference on Harmonisation Good Clinical Practices IFG: Impaired Fasting Glucose

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