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The Positive And Biological Effects Of Radiation

Decent Essays

Biological Effects of Radiation
Radiosensitivity
DNA as main cellular target –
Cellular role of DNA – DNA is a double helix molecule made up of two sugar phosphate backbones that are linked together at the bases: Adenine-Thymine and Guanine-Cytosine. DNA is responsible for cellular structure and function.
Direct vs. indirect DNA damage – ** Direct damage - Direct ionization has charged particles such as alpha, protons, and electrons. Direct damage to the nucleus of the atom is the direct damage to the DNA cell. Has the ability to rip electrons off of an atom. Indirect Damage - Indirect ionization is with x-rays, gamma rays, and neutrons. “Indirect ionizations cause secondary effects:
Radiolysis - splitting of water. An electron can be ejected to form h20+.
This electron can be absorbed by another atom to form h20-. These ions can form ion pairs or highly reactive free radicals. All can recombine to form water, hydrogen peroxide, or interact with the cellular components of a cell such as the nucleus. “ (Radiation Therapy Essentials Board
Preparation Tool)
“Low LET radiation causes damage primarily through the formation of free radicals” ****
Types and results of DNA damage-
Single strand breaks is when one piece of the backbone of the helix is broken; base deletion. 2000 per cell after typical daily dose of 180-200 cGy. This can easily be repaired. Radiation will damage the cell then enzymes come in and heal the damage with another strand. Sometimes the

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