The Relationship Between Ghrelin And Eating Disorders

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What Is the Relationship Between Ghrelin and Eating Disorders?
Ghrelin, commonly referred to as the “hunger hormone,” is a 28-amino acid peptide that has many important roles in human digestion including regulation of growth hormone release, enhancement of appetite, and increase of food intake (1). This gut-derived peptide could play an extremely important role in the altered eating behaviors of patients with eating disorders. Increased fasting plasma ghrelin levels have been consistently reported in underweight patients with anorexia nervosa. Circulating levels of this hormone have also been found to be enhanced in symptomatic bulimic patients, while also being blunted in response to balanced meals (4).
Because of ghrelin’s effect on appetite and its suggested role in eating disorders, this research will aim to investigate ghrelin’s relationship with anorexia nervosa (AN) and bulimia nervosa (BN). The following paper will determine exactly how these eating disorders influence ghrelin regulation or how ghrelin levels may influence the eating disorders themselves. This paper will examine ghrelin’s functions, the two eating disorders, and what that relationship precisely is by examining ghrelin’s metabolic actions as well as two clinical trials that explore its role in bulimia nervosa and anorexia nervosa.
Metabolic Basis Ghrelin has many roles in the body’s metabolism, one of which is serving as the natural ligand for the growth hormone secretagogue receptor.
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