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The Role Of Medical Therapy Post NSTEMI

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The role of medical therapy post NSTEMI: On earliest recognition of NSTEMI, initial medical therapy is indicated in all patients. Analgesia is required in all patients, and patients who are hypoxaemic or who have respiratory distress should also be given supplemental oxygen therapy. [12] Anti-thrombin and antiplatelet therapy (300-325mg of aspirin and a P2Y12 receptor inhibitor) are also indicated. For high-risk patients triple antiplatelet therapy, in which an intravenous GPIIb/IIIa inhibitor is also added, can be considered as it has shown to reduce the risk of peri-procedural death and MI in patients undergoing PCI. [13] Patients who are not at high-risk of bleeding should be offered fondaparinux, unless they have an angiography planned …show more content…

[17] In some patients who are considered to be at high-risk for recurrent thrombosis, oral coagulation may be indicated at discharge. The nature of complications from PCI: Common complications of PCI are bleeding, haematoma, and pseudoaneurysm to the access site. Some strategies such as using bivalirudin (thrombin-inhibitor), the radial approach and using proton pump inhibitors in patients on dual antiplatelet therapy who are at higher than average risk of gastrointestinal bleeds appear to reduce the risk of post-PCI bleeding. During the procedure, when the lumen diameter is widened, this is associated with major local trauma to the vessel wall so can, in turn, lead to complications in a minority of patients such as coronary perforation, dissection or rupture. Coronary perforation or rupture occurs in fewer than 1% of cases, making it very rare. Abrupt vessel closure may also occur, usually when the true lumen is compressed by a large dissection flap or thrombus formation, but the incidence of this has reduced significantly since the use of intracoronary stents and newer antiplatelet drugs. [18] Restenosis after PCI needing a second revascularization procedure is a major limitation, the rates of this have fallen to less than 10% with the introduction of DESs. Typically, it develops within 3-6 months and presents as a return of angina, it rarely causes MI. Stent thrombosis is a risk in 1-2% of patients, it is most frequent in the first month but can months or

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