The Role of Gut Microbiota in the Exaggeration of Kwashiorkor

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Smith et al. investigated the importance that the role of gut microbiota and diet that cause and exaggerate kwashiorkor, a severe form of malnutrition, in both monozygotic and dizygotic twins from Malawi, a country in Africa. The study tested twins, one that was well-nourished and one that was discordant, to evaluate changes in the bacteria of the gut while changing their diet, and the study also investigated the effect of fecal transplants to gnotobiotic mice to see how the gut microbiota along with the Malawian diet contribute to kwashiorkor by looking at the bacteria present before and after transplantation. The research is treated as a baseline study, and the authors hope that the results of the study can eventually be expanded to …show more content…
Smith et al. investigated the importance that the role of gut microbiota and diet that cause and exaggerate kwashiorkor, a severe form of malnutrition, in both monozygotic and dizygotic twins from Malawi, a country in Africa. The study tested twins, one that was well-nourished and one that was discordant, to evaluate changes in the bacteria of the gut while changing their diet, and the study also investigated the effect of fecal transplants to gnotobiotic mice to see how the gut microbiota along with the Malawian diet contribute to kwashiorkor by looking at the bacteria present before and after transplantation. The research is treated as a baseline study, and the authors hope that the results of the study can eventually be expanded to better understand how to treat and prevent such terrible malnutrition in other underdeveloped countries.
The results show that kwashiorkor in Malawian twins was caused by the diet of the area and the gut microbiome of the individual. Analysis of the data found showed that changes in the levels of bacteria will change when the diet changes. There are some aspects of the study that are not clearly explained in the article and if elaborated, may contribute to more concise findings. First, Smith et al. only used young twins in the study to investigate the microbiome with the diet. Although twins create a control group within human studies, there can be negative aspects, such as differences between twins and the rest of a population. The twins are
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