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The Role of Gut Microbiota in the Exaggeration of Kwashiorkor

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Smith et al. investigated the importance that the role of gut microbiota and diet that cause and exaggerate kwashiorkor, a severe form of malnutrition, in both monozygotic and dizygotic twins from Malawi, a country in Africa. The study tested twins, one that was well-nourished and one that was discordant, to evaluate changes in the bacteria of the gut while changing their diet, and the study also investigated the effect of fecal transplants to gnotobiotic mice to see how the gut microbiota along with the Malawian diet contribute to kwashiorkor by looking at the bacteria present before and after transplantation. The research is treated as a baseline study, and the authors hope that the results of the study can eventually be expanded to…show more content…
This disease may react differently in people with different diets, such as a protein-based diet often seen in America. The changes in bacteria may not be significant with other diets, which could mean there is a different factor contributing to the change in the microbiota. Third, the Malawian diet was not defined well, and it is only stated that there is a lack of protein in what the people of Malawi eat. Although protein is important, there may be other aspects of the diet that contribute to kwashiorkor that were not examined, such as the effect on any plants or vegetables consumed.
This study gave a base line for the topic of malnutrition and the effects in Malawi with a certain diet, either the Malawian diet or RUTF, which is peanut-based. The article states that the findings will hopefully be used to treat and prevent the serious malnutrition seen in the disease kwashiorkor. The study could go into further detail about the diet and the location of Malawi to show how the cultural and geographical factors contribute to the disease. The paper is indecisive in that the methods for determining bacterial species were not clearly explained. The figures show the importance of the changes in levels of different bacteria, but the specific method of understanding the results is not explained. Next, the information derived from the paper should be used, as suggested, to further
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