Author: Haley McDaniel, Pharm.D. Candidate
Date Answered: November 2, 2015
Question:
47. Should topiramate be considered for the treatment of bulimia nervosa?
Answer: The drug Topiramate is a sulfamate-substituted derivative from the monosaccharide D-fructose that is known for its anticonvulsant and antimigraine actions.1 Therefore, it is helpful for patients with seizures and migranes. Epilepsy is a specific example of what this drug is used to treat. Topiramate is different from other antiepileptic drugs because it is thought to block the spreading of seizures instead of lowering the threshold like other antiepilepsy drugs. 2 Although the exact mechanism that Topirmate cannot be identified, it is currently being observed from biochemical studies. Scientist have observed that the drug blocks voltage-dependent sodium channels, augments the activity of gamma-aminobutyric acid, antagonizes the AMPA/kainite subtype of glutamate receptor, and inhibits carbonic anhydrase. 1 Should this medicine be used to treat bulimia nervosa? Bulima nervousa is a disease that causes patients to engulf large amounts of food in a short amount of time, which then causes them to take action by purging or taking laxitives to get rid of the large sum of food they consumed. 3
There was a study that used a randomized, Double-Blind, Placebo-Controlled Trial, to test if Topiramate had an effect on the behavior, body weight, and quality of life related to health in patients suffering from
In “Anorexia Nervosa and Bulimia: The Development of Deviant Identities", which was published in 1987, the researchers utilized the labeling theory in their study on anorexics and bulimic victims. The current appearance norms in society demand thinness for women and muscularity in men. Social and Individual factors were considered in the studies which were conducted by the authors, Penelope A. McLorg and Diane E. Taub. Advertising has become the primary agent of socialization which promotes the slimness of both genders in our society. The researchers noted conformity in the behavior of the anorexics' and bulimics' families tend to conform to the norms by making close relations. In the study, the researchers found that parent’s opinions on
Bulimia nervosa, also called bulimia is a possible life threating eating disorder. A person that suffers from bulimia may secretly binge their food. They may eat large amount of food and then purge their food to get rid of the additional calories that they’ve digested. Bulimia is categorized in two ways, purging bulimia and non-purging bulimia. Purging bulimia is when a person regularly self-induces vomiting after eating. Non-purging bulimia is when an individual may use other methods to try to prevent weight gain, such as fasting, extreme dieting, or overly exercising.
Bulimia nervosa is an eating disorder with psychological, physiological, developmental, and cultural components. The disorder is commonly characterized by binge eating followed by inappropriate compensatory behaviors, such as self-induced vomiting, excessive exercise, fasting, and the misuse of diuretics, laxatives or enemas. Patients properly diagnosed with bulimia nervosa endure many psychological and physiological problems. In order to alleviate these problems for the patient, usually some type of intervention is required. Considering the financial costs to the patient who seeks treatment, it is important to
After reading, “Anorexia Nervosa: Friend or Foe?” by Serpell et. al., in 1998, “Bulimia Nervosa: Friend or Foe? The Pros and Cons of Bulimia Nervosa,” by Serpell and Treasure in 2001, and viewing the documentary, Dying to be Thin, from PBS in 2000, I found several significant points within this research. Specifically, AN is the deadliest of all psychiatric disorders and the most difficult psychiatric illness to treat. As mentioned in the video Dying to be Thin, while detection as well as treatment are critical for individuals suffering from AN and other eating disorders, the potential related health risks may be serious as well as irreversible, including osteoporosis, cardiac arrest, and amenorrhea leading to infertility as well significant
Bulimia nervosa is an eating disorder characterized by binge eating as well as by self-induced vomiting and/or laxative abuse (Mitchell, 1986). Episodes of overeating typically alternate with attempts to diet, although the eating habits of bulimics and their methods of weight control vary (Fairburn et al., 1986). The majority of bulimics have a body weight within the normal range for their height, build, and age, and yet possess intense and prominent concerns about their shape and weight (Fairburn et al., 1986). Individuals with bulimia nervosa are aware that they have an eating problem, and therefore are often eager to receive help. The most common approach to
There are many psychological effects of bulimia on the people who are suffering from it. They tend to feel unwanted, having difficulty in maintaining relationships, irritability, can’t eat with others, withdrawal from daily life activities, stress, depression etc. (Your Bulimia Recovery, 2011). One of the major drawbacks of being a bulimic is the loneliness you feel. Therefore, communities play a major role in positive or negative health outcomes. Disorganized communities, poor health services, no family support and poverty are related to poor health outcomes (Clark, 2001). It can also damage a person’s mental, physical and emotional health and can also affects his/her self-esteem and confidence (Neda Feeding Hope, 2015). The patients suffering
(14). Klein KM, , et al .Topiramate, nutrition and weight change: a prospective study. J Neurol Neurosurg Psychiatr, 2008; 79:590–3.
Bulimia has come to be known as bulimia nervosa for its similarity to another eating disorder known as anorexia nervosa, and also known as the binge- purge disorder for its cycle of bingeing and purging. Like anorexia, bulimia is normally developed during adolescences or early adulthood and “both are characterized by severely restricting food consumption.” (“Bulimia Nervosa”) However, unlike anorexia, bulimia is also characterized by binge eating. Binge
Eating disorders are classified as mental disorders and can lead to life threatening damage. It is important to manage eating disorders to prevent health effects. There are many different possibilities for patients with disorders. Common treatments for eating disorders can consists of counselor or therapists. Early detection is important to limit future oral health effects. A dental hygienist has an advantage to see the inside of the mouth for possible trauma, erosion, and malnutrition. It is common for patients to be in denial of the situation. A dental hygienist is trained to communication to the patient about the eating disorder without the patient feeling attacked. It is important to tell the difference in eating disorders. Most eating disorders all appear to be anorexia until further signs and symptoms are observed. The two types of eating disorders being discussed in this paper are anorexia nervosa and bulimia nervosa.
Somewhere across the globe there are children waking up with empty stomachs, scavenging for any scrap of food they can find. For some people in America though, ironically enough, there are those who purposefully do not eat, or push back up what they have eaten. Women and men in the American society are influenced by a beauty ideal so powerful that has taken peoples lives through starvation, despite being surrounded by food. This phenomenon is known as bulimia. Bulimia, as defined by the Merriam Webster dictionary, is “a serious eating disorder … characterized by compulsive overeating usually followed
From an objective point of view, my physical health was crumbling before my eyes. From a subjective point of view in my very disordered mind, I was completely fine. I have lost to, fought against, rose up from, and recovered from an eating disorder. I was able to solve this majorly risky problem. At age sixteen my self-esteem was extremely low and my weight was at an all-time high. A doctor would say I was healthy for my age; however, my insecurities would not let me see it. The desire to lose weight was so strong I began the dark path down the road of bulimia. At age sixteen, I was aware that I had an eating disorder and it was not until two years later that I would seek treatment for it.
According to the DSM-5, eating disorders are characterized by a persistent disturbance of eating–related behavior that results in non-normative eating patterns which leads to impaired physical and psychosocial functioning, (American Psychiatric Association, 2013). Bulimia Nervosa is an eating disorder characterized by recurrent episodes of binge eating with inappropriate compensatory behaviors to prevent weight gain. Binge eating is described as eating an amount of food definitely larger than normal with a sense of lack of control. Compensatory behaviors include misuse of laxatives, self-induced vomiting, diuretics, fasting and excessive exercise, (Comer, 2014) . Another key feature is
While the causes of bulimia are not limited to the 3 above, this paper will only investigate the ones listed. However, in order to fully comprehend how these can lead to bulimia nervosa, the reader must first understand the condition as a whole. This paper will eventually break down the 3 categories, but first, the symptoms of bulimia, the diagnostic process, and the negative health effects that accompany the condition will be briefly described.
Anorexia nervosa and bulimia are eating disorders that severely affect both men and women around the world. The cause of the eating disorder usually derives from psychological, biological and social forces. Eating disorders have become an epidemic in American society, twenty-four million people of all ages and genders suffer from an eating disorder in the U.S. (National Association of Anorexia Nervosa and Associated Disorders.\, 2011). There are many ways to address and treat an eating disorder. There have been multiple studies conducted to test the effectiveness of different types of treatment. My central research question analyzes the relationship between the continuation of the eating disorder with the presence of intervention or some
A placebo-based study performed at Cardiff University (UK) included 755 participants, over 4-months, at 3–5 doses, daily.