In the research paper, Transfer of a malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients by Dana Hamam and her colleagues, the idea of any cells within the human body that contain a single oncosuppressor mutation and can assimilate cancer factors and endure a successful malignant transformation is explored. Hamam first goes into detail about the background of cancer. A person that is diagnosed with cancer, it is usually the metastasis (the spreading) of cancer that instigates the poor healthy and possible death of the individual. Due to the statistic, Dana Hamam reviewed a piece of literature that explained the possibility of that the primary tumor cells may not be the only thing spreading throughout the body of cancer patients, but cancer cell-derived factors may also be making their way through the body as well. These cancer cell-derived factors, in theory, would create a niche that would allow malignant cancer cells to take host in other organs in the body. The factors could be numerous things such as proteins or nucleic acids that may perhaps be either floating around in the bloodstream or hitching a ride in exosomes (small extracellular membrane-enclosed vesicles). This process of trait transfers through blood circulating factors is named genometastasis. Hamam actually did an experiment on human embryonic kidney cells (HEK293) that was exposed to cancer. Those embryonic kidney cells were transformed into malignant cancer
In just 2016, about 595,690 people in the United States will die because of cancer.
Cancer, medically called ‘tumorigenesis’ (Thaker, Lutgendorf, & Sood, 2007, p.430) occurs when cells in the body orient themselves for malignant growth. Such cells show ‘self-sufficiency in growth signals’, are ‘insensitive to anti-growth signals’ and have ‘limitless replicative potential’ (Thaker, Lutgendorf, & Sood, 2007, p.430). Once a particular set of cells become malignant, the malignancy can spread to other set of cells in different organs due to ‘crosstalk’ between the affected cells and their surrounding ‘tissues’ and ‘micro-environments’(Thaker, Lutgendorf, & Sood, 2007, p.430).
The American Cancer Society is one of the most effective ways to learn about the different the various types of cancer. The reason why I chose this organization is because I recently lost a very dear friend to brain cancer. A lot of people do not know the signs and symptoms of cancer and I feel as if this is a great way to inform people about it.
Malignant tumor or malignantneoplasm, also known as cancer, is a disease caused by abnormal cell growth. The cell is potential to spread to other parts of the body. But not all tumors are cancerous such as benign tumors. They do not invade to other parts of the body. Some people may have symptoms such as abnormal bleeding, a prolonged cough, a new lump, unexplained weight loss, and a change in bowel movements among others. But those symptoms do not only indicate cancer, they can also occur because of other issues. Actually, there are over 100 different known cancers that affect humans.
In the Topic of Cancer, Christopher Hitchens writes about his experience with Cancer and uses various claims in order to provide an audience with a well-written rhetorical essay. The Topic of Cancer begins with Hitchens describing the morning he found out he had cancer. He remembers feeling like death, literally. Throughout the essay, Hitchens uses claims and rhetorical statements to help the audience who cannot personally relate to cancer. I have had more than my fair share of experiences with cancer. My sister, niece, and mother were all diagnosed with cancer. Sadly, only my mother survived the “battle” against the “new territory,” as Hitchens describes it. Cancer patients should be thoroughly informed about their cancer treatment options that evaluate issues such as life expectancy and the quality of life they will be living in order for the patients to make informed decisions about the treatment they choose to receive.
This ability of malign cancer to make their way across basement membrane and into blood vessels is what makes cancer so fatal and impossible to be cure by surgery alone. The result of metastasis and invasion in normal tissue by cancer cells are often seen as one of the distinctive features of malignancy (Ruoslahti 1996). Even though the ability of invasion and metastasis are one of the hallmarks for cancer, these abilities are not unique to cancer cells as it can also occur during the early development stage of the embryo, in healthy organisms and in many noncancerous diseases (Mareel & Leroy 2003). It does not matter whenever the organism has developed benign or malign cancer, all cancer cells have the ability to disturb the normal cell cycle and threaten the survival of the organism.
Cancer is a disease that can change the life of a person no matter their age or nationality. Cancer can range from being life threatening to a low risk of death. Cancer cells are cells that do not follow the regular cell growth and division pattern. They go through cell division and produce rapidly. Cancer cells differ from regulating cells in the body because normal cells eventually die. Cancer cells, on the other hand, do not die when they should causing it to be very hard to cure cancer in your body.
One may also inherit a gene that makes them more susceptible for breast cancer. BRCA 1 and 2 are tumor suppressor genes that when inactivated they indirectly disrupt DNA repair. This can cause cells to increase the number of mutations they have, which in turn can cause cancer. Healthy cells in the body are arranged in an orderly matter. These cells stay in place due to cell adhesion proteins which keep the cells in place. There are specific genes that signal cells to make protein adhesion cells. When these genes are damaged by mutations, the cell adhesion proteins are no longer able to
cancer is a collection ofrelated diseases and it can start almost anywhere in the human body. Cancer occurs when cells begin to grow and myltiply in an uncontrolled way. This is because cells usually kills itself when it is damaged or grow old, but when abnormal cells don't kill itself but replicate again and again witout stoping cancer happens.
Cancer is a disease of the body’s cells. It occurs when abnormal cells grow in uncontrolled way, which can damage and invade surrounding tissue and spread to other parts of the body. When cancer cells are confined to one area and do not spread, they are referred to as benign and are not dangerous. However, if the cells have the ability to spread to surrounding areas and different parts of the body, they are referred to as malignant or commonly known as cancer (Cancer Council Australia, 2016, “What is cancer?”). The Australian Institute of Health and Welfare suggests that cancer patient survival rates have increased over the years with treatment advances playing a key role. There are several treatments depending on the type of cancer and how advanced it is, among these are chemotherapy and radiation therapy. Each of these treatments use different strategies with a common aim to destroy cancer cells in the body. However, there is substantial evidence that both chemotherapy and radiation therapy are associated with causing cognitive impairments in patients due to their effects on the brain. Research findings suggest about 75% of cancer patients experience problems with cognitive functioning during treatment, and up to 35% have issues that continue for months after the treatment has finished (Cancer.Net Editorial Board, 2015). The following report discusses the possible implications on cognitive functioning in adults and children receiving these treatments.
A tumor, also known as a neoplasm, is an abnormal mass of tissue which may be solid or fluid-filled. A tumor does not mean cancer - tumors can be benign (not cancerous), pre-malignant (pre-cancerous), or malignant (cancerous). There are many different types of tumors and a variety of names for them - their names usually reflect their shape and the kind of tissue they appear in. A tumor is a kind of lump or swelling, it does not necessarily pose a health threat. Tumor are not necessarily cancerous, Benign tumors cannot spread, fibroids are benign tumors that grow on fibrous or connective tissue, lipomas consist of adipose tissue, a premalignant tumor is one that is not yet cancerous but is about to be, Cancerous tumors are referred to
Cancer is one of the most ambiguous diseases. As Jenny Phillips, a researcher in the thoracic oncology field, said, “I think the thing you need to know most about cancer is that we don’t know that much about it.” Yes, it is known that cancer is the uncontrollable division of abnormal cells, but how can it be stopped? That is the question. There are a number of treatments for this disease. There are the traditional treatments: chemotherapy, radiation, and surgery. There are also nontraditional treatments such as the use of oncolytic viruses, acupuncture, and the targeting of matrices. Aside from these treatments, are some other treatments that have recently been on the rise: personalized medicine, targeted therapy, and stereotactic radiosurgery. However, despite the number of treatments available for cancer, it is yet to be determined which is the most effective. Part of the problem lies in the fact that cancer is an individualized illness; each cancer is different and acts differently. Gliomas are difficult to treat due to the low accessibility of tumors inside the brain due to the Blood Brain Barrier (BBB). Lung cancer can be difficult to treat, because blood flow to the lungs is very different from that of other organs in the body (Jenny Phillips). In addition to the specifics of each location of the body, each person is different and has a unique genetic make up. This means each cancer will manifest within a certain set of genes which makes the task of finding a
Determining what is the best treatment for an individual is based on the pathology of the disease. The initial biopsy is done when cancer is first suspected, it will tell what kind of cancer is present and whether it is hormone receptive. Knowledge of hormone receptors, or not found, will be part of decision making information to treat an individual. Some types of tumors are stimulated by hormones that are normal in the woman's body, such as progesterone, estrogen, and HER-2. A tumor may show a positive response to one or more of these hormones. By knowing this information, a treatment plan can be offered that can increase the chances of a woman's cancer-free survival.
The purpose of the G1 phase is so the cell can grow, increase size, and create proteins and organelles, being able to take up to a total of 11 hours. During the G1 phase of a normal cell, the p53 gene monitors and destroys any cells with damaged DNA. In a cancer cell, the p53 is most likely to have a mutation in the p53 gene which results in the having damaged DNA not being destroyed. Even with those differences, some similarities is that both type of cells grow and increase size in the G1 phase. In the S phase, the DNA replicates in the nucleus taking up to 8 hours, but can often vary based off of the number of DNA necessary to replicate. What separates a normal and cancer cell is that a cancer cell will still replicate damaged DNA while a
The fever, aches, pains, weakness and the feeling of death nearby comes by as one never expects it, and this is called cancer. It has become an epidemic as statistics show an increase of deaths from this horrible disease throughout the years. There are many organizations that support the development of new treatments and strategies to decrease these numbers. Although, this battle has been going on for a long time, there is one thing that always has shown to benefit people. As we take a look through medical/scientific research, we can understand the relation between physical activity and cancer.