What Is Melanocortin 1 Manogen?

Chimpanzees have what is called melanin, which is a dark brown pigment that protects them from UV radiation. Melanin is a natural sunscreen, which filters out UV radiation. It is been proven that people with high concentration of melanin in their skin heading to come from tropical areas and it has protected them from skin cancer. After all of this research, Jablonski and Chaplin then ask, “what role melanin might play in human evolution?” (170).

Jablonski and Chaplin describe melanin as nature's sunscreen. They also define melanin as “a large organic molecule that serves the dual purpose of physically and chemically filtering the harmful effects of UV radiation; it absorbs LTV rays, causing them to lose energy, and it neutralizes harmful chemicals called free radicals that form in the skin after damage by UV radiation.” Anthropologists and biologists had rationally believed that people living in tropical areas had higher concentrations of melanin in the skin to serve as protection against skin cancer. James E. Cleaver of the University of California in San Francisco refuted this idea. He stated that most skin cancers appeared later in life so in conclusion the amount of melanin that a dark skinned person produced had no relation to skin protection. Cleaver showed that diseases like xeroderma pigmentosum, a disorder in which the ability to repair damage caused by UV light is deficient, and melanomas, a serious type of skin cancer that develops in the cells that produce melanin, can be rare and even fatal. The authors ended up questioning the role that melanin played in human

Melanoma is the most dangerous type of skin cancer. It develops when unrepaired DNA damage to your skin cells trigger genetic defects that lead you skin cells to multiply at a fast pace and form tumors. Melanoma can often resemble moles and some can come from previous moles. These melanoma moles can range in color from pink, red, brown, purple, white, blue and skin-colored, but more mostly seen as black or brown. It’s said that consumers who use indoor ultraviolent tanning devices are seven-four percent more likely to develop melanoma compared to someone who has never used a tanning bed before. Melanoma is usually caused from intense and over exposure to UV radiation. It has be estimated to kill around 10,000 individuals in the U.S. each year. The lifetime risk of melanoma is 1.5 times higher in males than in females. Melanoma is curable, if it is recognized early and

Melanotan 2 is a substance that helps stimulate melanin production. Melanin is a dark brown or black pigment that is naturally found in the skin. It is naturally produced when the skin is exposed to the sun. The skin produces extra melanin in order to protect the skin from further sun damage.

Neanderthals and modern humans became one species, through thousands of years of interbreeding. Supporters of this theory state that some modern day Europeans have facial features similar to Neanderthal man. Neanderthal genes may have been inserted into the human gene pool, and Human genes may have been added to the Neanderthals. At this point, Neanderthals and humans may have evolved together at an incredible rate, becoming one race in a relatively short period of time. On the other hand, a disease, a war, or an increase in population causing the natural resources to be inadequate for keeping so many hominids alive might have cut off Neanderthals suddenly from contact with the humans,

“All four Neanderthals yielded the mtDNA sequences similar to those previously determined from Neanderthal individuals, whereas none of the five early modern humans contained such mtDNA sequences. In combination with current mtDNA data, this excludes any large genetic contribution by Neanderthals to early modern humans, but does not rule out the possibility of a smaller contribution” (Serre, 16 March 2004).

Familial melanoma is a genetic or inherited condition. This means that the risk of having a melanoma can be passed from generation to generation in a family. Ordinarily, each cell has two copies of each gene: one inherited from the mother and one inherited from the father. Familial melanoma follows a dominant inheritance pattern, in which case a mutation happens in only one copy of the gene. As every cell has two copies of each gene, it means that a parent can potentially pass along a copy of his or her normal gene or a copy of the mutated gene. Therefore, a child who has a parent with a mutation has a 50% chance of inheriting that mutation. A related person such as a brother or a parent of the person who has a mutation also has a 50% chance of having the same mutation.

Some people are born with more melanin than others. People with dark skin have more melanin than people with light skin. Some people are born with no melanin at all, and they are called albinos (Stewart, 10). Too much time in the sun produces extra melanin which protects the skin from the sun’s rays, and also makes lighter skin get darker, or suntanned. But if too much time is spent in the sun, it can result in a sunburn, and this can lead to skin

Those who have light skin, hair, and/or eye colors are at an increased risk for developing melanoma over their opposite counterparts. Risks escalate for those who are sensitive to the sun and develop sunburn easily, have a history of intense sunburns, or never tan. A family history of melanoma is another risk factor associated with developing the disease. Persons with a personal history of melanoma are at a greater risk of recurrence. Significant numbers of freckling and moles in an individual is an additional risk factor in developing melanoma. Controllable risk factors include the use of ultraviolet radiation tanning beds, and the time one spends in the sun under natural ultraviolet radiation (Calianno, 2011). Sunburns in later life and cumulative lifetime exposure to ultraviolet radiation are important factors in the development of melanoma, but blistering sunburns in early childhood markedly increase a person’s risk

Melanoma is the most serious type of skin cancer. You can get melanoma from the sun, it can be genetic or from tanning beds. Melanoma is mostly on skin, but also found in eyes, under nails, and sometimes found in organs. It’s increasing to a lot of people under the age of 40, especially women. Melanoma can be in many places. Next, the sun and tanning bed increase your chances

According to the Skin Cancer Foundation, one in five Americans will develop skin cancer in the course of a lifetime. Consider that 90% of nonmelanoma skin cancers are associated with high exposure to UV radiation from the sun (which means 90% of nonmelanoma skin cancers are preventable!) WebMD reports that Melanoma ( a severe type of skin cancer) often starts as a change in skin or a mole growth.

Not everyone is ready to draw such decisive conclusions about the Neanderthal mind from DNA however. John Hawks of the University of Wisconsin-Madison notes that Neanderthals may have carried gene variants that affected their brain function but that have no counterparts in modern humans for comparison. He remarks that if one were to envisage Neanderthal skin color based on the genes they share with modern humans, one would infer that they had dark skin. Yet scientists now know Neanderthals had some genes no longer in circulation that probably led to their possessing light skin. The larger problem with attempting to determine how Neanderthal brains worked from their genes, Hawks says, is that for the most part researchers do not know how genes

In the past few years, advancements in biotechnology and a growing collection of hominid bone remnants have allowed paleoanthropologists to gain insight into how populations of different archaic hominid species interacted. In particular, sequencing of the Neanderthal (Homo neanderthalensis) genome has provided evidence that the evolution of anatomically modern humans (Homo sapiens) was influenced by interbreeding and gene flow between the two species of Homo. By comparing Neanderthal and modern human DNA, researchers have been able to produce evidence that would support the notion that not only was interbreeding possible, but also that it likely happened and produced a selective advantage.

The first Neanderthal fossils found in Europe, a fragmented child’s cranium in Belgium in 1830, and an adult cranium in Gibraltar, were not immediately recognized as a divergent kind of human. Only in 1856 after a partial skeleton was found in a cave in the Neander Valley in Germany it became clear that these fossils belonged to an extinct human and our closest evolutionary relative (Hublin and Pääbo, 2006). Since then, questions about their relationship with modern humans have been fiercely debated between anthropologists. But what attracts most interest from scientists and popular media is the possibility of hybridization between Neanderthals and modern humans if, in other words, they were a genetically different specie or a

A major function of melanin is to act as a defensive barrier of the skin against radiation damage. Ultraviolet light between the wavelengths 280-320nm (UV-B) causes sunburn and damages the skin on nonpigmented peoples. Exposure to this degree of light causes their skin to become dry, leathery, and wrinkled in appearance similar to that associated with aging. This can be seen in Whites living in Australia and South Africa, where ultraviolet light intensity is high because of the relative latitude or closeness to the equator.