Botulinum Toxin
What is Botulinum Toxin?
Botulinum toxin is the world’s strongest natural toxin that is created by the growth of clostridium botulinum, an anaerobic bacteria; Botulinum toxin only grows under limited oxygen levels and at temperatures less than 80degreeC. Although botulinum toxin can be ten times more deadly than cyanide and causes botulism, it has many practical medical uses. Botulinum toxin is a protein and has seven structural types. However, only botulinum toxin A and botulinum toxin B have been approved for medical and cosmetic use. Botulinum toxin, most often known for its cosmetic uses such as Botox, has many other medical uses. Some practical uses for botulinum toxin include it being used as a muscle relaxant and pain killer.
Introduction to how BT works?
Botulinum toxin is very effective in reducing pain and muscle spasm. When botulinum toxin is released into the body, it blocks the release of acetylcholine , a neurotransmitter that cuts off the signal between nerves and muscles. When one’s nerves stop transmitting signals to the muscles, one cannot feel pain as strongly, thus reducing pain and one muscles relax.
The Structure of BT?
Botulinum toxin A and botulinum toxin B are the only serologically differentiated botulinum toxins that are available for commercial and medical uses. Botulinum toxin A and botulinum toxin B both have polypeptides, which is a peptide chain connected by amide bonds. The light 50-kDa dichain polypeptide and the
Botox (Botulinum toxin type A) is known and has been approved by the Food and Drug Administration for removing facial wrinkles. It is also known as the most potent type of Botulinum toxin. Making men and women look younger and feel healthier is what this drug is cosmetically known for along with the side effects. The Botox is injected directly into the face, and reduces wrinkles for a period of several weeks to months. Although its use is strictly controlled, there have been reports of fatalities and sever side effects from extreme uses of Botox. It is also known for treating headaches and helping people not only in the
Exercising will also help decrease nerve pain. Walking or swimming are both great for the entire body and will relieve nerve pain. Yoga and stretching are great ways to help lessen inflammation and pain. In addition, meditation is very calming for the mind and body. It is best to meditate for about ten to fifteen minutes in the morning and at night before going to
Medicines. These include muscle relaxants, sedatives, and medicines called anticholinergics. Treatment with medicine is less successful than injections.
We have incorporated Chinese herbal medicine, acupuncture and cupping and massage. The ultimate goal at our Irving massage therapist center is to provide customers with a world-class sports massage that reduces the muscle pain. Kalpesh Patel runs the clinic, and he is licensed in acupuncture, and he has earned a Master's degree in acupuncture with the AIAM. Using our sports medicine, you can recover faster and alleviate pain throughout the different parts of your body. For athletes, these are things that are unavoidable because they are caused by too much
Clostridium botulinum produces botulinum toxin which is the strongest human known toxin. This makes it have great potential for use as a bioweapon. The concern for this has risen due to Iraq’s production, under Saddam Hussein’s rule, of 19,000 liters of botulinum toxin in 1995. This amount is enough to kill the entire population of humans on earth, three times over. The use of this neurotoxin could be in the form of aerosol or food contamination. For this reason, it is highly studied. It is also the reason I picked Clostridium botulinum as the bacterium to do my research paper on.
Viperitoxin decreased the twitch response by around 52-53% and decreased the KCl response by around 113%. There was no CCh response as it was not tested. Taipoxin decreased the twitch response by 83%, whilst the CCh response did not change, but increased the twitch response of KCl by 18%. For α-bungarotoxin, the twitch response decreased by 97%, whereas the CCh response by decreased 84% and the KCl response decreased by 19%.
The illness of topic that is rare but potentially fatal that is caused by a toxin is Botulism. In the United States, health care providers report an average of 110 cases per year. The botulinum toxin is a neurotoxin protein. The causative organism that makes up this toxin is Clostridium botulism and sometimes Clostridium butyricum or Clostridium baratii. They are the gram-positive, rod-shaped, spore-forming, obligate anaerobic bacteria. The bacteria that make this toxin are naturally found in many places and it is rare for them to make people sick. This bacterium makes spores that act like a protective coating. The spores help these bacteria survive in the environment, even in very extreme conditions. The spores even when eaten usually do not make people sick but under certain conditions they can grow and become
This document will answer many questions about Botulism Toxin. Some of the questions addressed will include; What exactly is botulism? What is the germ Clostridium botulinum? How frequent does botulism occur? What are the symptoms of botulism? How do we diagnose botulism? How do we treat botulism? What are complications from botulism? How does one prevent botulism? What are public health agencies doing to prevent and control botulism? I will also discuss other uses of Botulinum Toxin in the medical field as well as in the cosmetic field.
These bacteria can be found in in soil, dust and rivers. The bacteria is not harmful but when placed in and area where it does not have enough oxygen such as in closed tins, jars, bottles, soil and mud it produces poisonous toxins. Botulin can affect the nervous system by attacking the brain and the spinal cord. Resulting in muscle weakness and loss of muscle tone and subsequent paralysis.
Sean Mackey is a M.D, Ph.D, the current Chief of the Division of Pain Medicine, as well as a Redlich professor in several pain and brain related sciences at Stanford. Doctor Mackey leads the research at the Stanford Systems Neuroscience and Pain Laboratory focusing on the dissecting chronic pain and how it effects the nervous system. The SNAPL has also attempted to map out the brain and regions in the spinal cord that understand pain in order to treat these occurrences of chronic pain on a personal level (Stanford Medicine Bio). In order to solve these problems he is mainly explores the effects of different injected drugs, such as Lidocaine, Ondansetron, and Botulinum Toxin, for ameliorating effects or help in linking how different responders
C. Increase muscle excitation and contraction. Myasthenia gravis prevents muscles from contracting or acting sufficiently because antibodies target the acetylcholine receptors at the neuromuscular junction and muscles are not told to contract. The medicine blocks the breakdown
Production of toxins such as cytolytic that disrupt the cytoplasmic membranes of some cells, exfoliative toxins causing one's skin cells to separate, toxic-shock syndrome and enterotoxins which stimulate intestinal muscle contractions, nausea and vomiting.
Zytaze claims to fasten the healing process after a Botox procedure. The New York Daily News published a clinical trial about it and it stated that 92% percent of patients found the pill actually prolonged Botox effects.
To administer a nerve block, your doctor inserts a needle into your back near a nerve in your spine. He or she then injects an anesthetic through the needle that reaches the nerve and causes it to go numb. You should feel immediate relief from pain as the area in your back loses it's feeling. The problem with a nerve block is that the
Botox is short for botulinum toxin, a neurotoxic protein the bacterium Clostridium botulinum produces. Two main types are produced commercially: botulinum toxin