The transcription factor NF-κB is recognized to regulate a notable number of cellular signaling pathways, which are related to cancer. During carcinogenesis, NF-κB targets a number of cytokines, pro-inflammatory molecules, growth factors, cell adhesion molecules, oncogenes, also pro/anti-apoptotic proteins. NFkB is a ubiquitously expressed eukaryotic transcription factor that is answerable for the regulation of numerous genes. Five subunits have determined for NFkB: p50 (NFkB1), p52 (NFkB2), p55 (RelB), p65 (RelA), and c-Rel (Rel). When NFkB is activated by inducements such as bacterial lipopolysaccharides (LPS) or pro-inflammatory cytokines, it displaces to the cell nucleus and starts the expression of a variety of target genes, such as Tumor
The purpose of this research was to determine the mechanisms in naked mole-rats that restricts cell proliferation and tumor formation. Contact inhibition is a mechanism observed where cell proliferation stops when two cells come in contact with one another. This process is caused by elevated levels of p27 cyclin-dependent kinase inhibitor which stops cells in the G1 phase from dividing. The cylcin-dependent kinase inhibitor p16 is also thought to regulate contact inhibition but its levels do not change in mice or human samples. Tumor-suppressor genes Rb and p53 are present in high concentration during contact inhibition to help control cell proliferation and apoptosis respectively. It was hypothesized that the naked mole-rats' cancer resistivity
The National Security Agency mandate is to accumulate information and provide surveillance and security for the world. The National Security Agency focuses on keeping invulnerability to any outside threats and preserving the peace. The N.S.A. job is to provide “products and services to the Department of Defense, the Intelligence Community, government agencies, industry partners, and select allies and coalition partners”. (National Security Agency). The N.S.A. is also responsible for the “deliver[y] [of] critical strategic and tactical information to war planners and warfighters.” (National Security Agency). The job of the N.S.A. is imperative, not only to ensure safety for America, but amassing foreign intelligence data, collecting data, as
One study by Shuijun Zhanga et al had shown the ABT-737 induced apoptosis of hepatocellular carcinoma cells (HCC) by the transcriptional repression of Myeloid cell leukemia 1 (Mcl-1). Shuijun Zhanga et a. had shown that NCTD could affect apoptosis by the modification of the B-cell lymphoma 2
Nevertheless, there is a promising biomarker and therapeutic target on the horizon. Studies show that S100A8 is preferentially overexpressed in ATC3,6, leading to the formation of tumors and invasion of the trachea. Knockdown of this protein, however, abolished tumor formation6. It is thought that S100A8 interacts with the RAGE receptor to promote cell proliferation by activating the p38, ERK 1/2, and JNK signaling pathways2.6. Taken together, this indicates that S100A8 is a potential diagnostic biomarker and that targeting this gene will prevent progression of the
The interpretation factor Myc is an essential downstream focus of Ras-ERK flagging and numerous different pathways. It is much of the time opened up or overexpressed in malignancy; strangely, Myc can tie to promoter areas of qualities as well as upgrade transcriptional extension of polymerase II, in this manner expanding its belongings past qualities with Myc-restricting destinations in their promoters. Myc can fill in as an all inclusive intensifier of communicated qualities as opposed to simply authoritative to promoters and starting interpretation (Sever and Brugge, 2015). Development factor and cytokine flagging can impact the improvement of a few malignancy sorts. One of the key players in the improvement of tumor is Janus kinas (JAK) flag
CDK7 inhibition was a highly selective and potent means to disrupt expression of a key cluster of genes. This study demonstrates that inhibition of transcription is an effective strategy to target highly aggressive breast cancers such as TNBC with high genetic heterogeneity and lacking obvious ‘driver’ oncogenes. Further studies will be required to determine whether these observations will translate to clinical treatment of
Ceritinib is a potent inhibitor of anaplastic lymphoma kinase (ALK), a tyrosine kinase involved in the pathogenesis of nonsmall cell lung cancer (NSCLC). ALK gene abnormalities due to mutations or translocations may result in expression of oncogenic fusion proteins, that alter signaling, and expression and result in increased cellular proliferation and survival in tumors. The primary mechanism of
One factor that inhibits TNFa expression is IL-10, an anti-inflammatory cytokine produced by LPS-activated macrophages that suppresses LPS-induced expression of several proinflammatory cytokines. (Lawrence, 2009) Inhibition of the expression of TNFa by macrophages is associated with selective induction of the NF- κB p50 subunit. (Wessells et al., 2004) Overexpression of the p50 blocked LPS-induced transcription from a TNFa promoter construct, showing that this transcription factor is an inhibitor of the TNFa
NF-kB, a key transcriptional factor which have been found to be activated in a variety of inflammatory disorders such as cardiovascular, cancer and neurodegenration. Various research groups have reported the down-regulation of NF-kB by of Ganoderma in LPS induced immunological models [64,
After decades of experience, medical research is now focusing on slowing or preventing the progression of this cancer. By learning all the biochemical pathways involved in the initiation, progression, and proliferation of cancer, scientists hope that they can find ways to change how cancer develops.
Today, we live in an age where environmental and dietary carcinogens are more prevalent than ever before. Whether consciously or unconsciously, humans come into daily contact with harmful chemicals that cause cell damage and may result or directly contribute to the formation of cancer. Although this is a sad reality, fortunately, medical research and technology has also advanced to provide new hope in treating and eventually curing cancer. One such pathway that is currently being studied concerns a class of proteins known as "cyclins" which are found in all cells and regulate it's transition through different phases of life including cell division and apoptosis. There is still much that is unknown about the nature of cyclins and
IKBKB gene encoding the IkB kinase which plays an essential role in NFkB signalling pathway, it has kinase activity which phosphorylate the inhibitor of NFkB and targeting it for degradation, detail are shown as below.
Inflammation is generally an acute process that occurs in response to infection and tissue damage. This protective mechanism involves members of the innate immune system such as macrophages and neutrophils recognizing pathogen-associated molecular patterns (PAMPS) as well as damage-associated molecular patterns (DAMPs) and initiating mediators that increase vasodilation, edema and pain. Long-term inflammation can also occur and leads to a chronic state with conditions favorable for tissue damage and genomic lesions (1,2). Over time this genetic damage can lead to cancer. An example of chronic inflammation leading to cancer development can be seen in patients with ulcerative colitis.
To identify the actual proteins responsible for the tongue cancer chemopreventive activity of Streblus asper extracts, especially the ERK ½, caspases, and Bcl-2 family together with the proteins related to the cells proliferative activity such as Ki-67, PCNA, cyclin D1, p21 and p27 as well as the signal transduction pathway such as Mitogen-activated protein kinases (MAPKs) pathway.
Colorectal cancer is still a critical issue and threatening society’s health (36,37). Tumors have developed different mechanisms for deceiving, counteracting, and onslaught the immune defense (38). Tumor cells secret different soluble factors, cytokines, chemokines (16,38,39), and exosomes (40) that recruit different heterogeneous supporting inflammatory cells such as B-cells, T-cells, mast cells, fibroblasts, myofibroblasts, mononuclear cells (MNCs), macrophages and MDSCs in the TME. The TME infiltrate with the recruited different cells by secreted factors from tumors (39,41). These recruited cells secrets various soluble factors, such as tumor-promoting, inhibitory, inflammatory (e.g., IL-6, IL-12b, TNF-α, IFN-ɣ),