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Why Is Nfkb Important

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The transcription factor NF-κB is recognized to regulate a notable number of cellular signaling pathways, which are related to cancer. During carcinogenesis, NF-κB targets a number of cytokines, pro-inflammatory molecules, growth factors, cell adhesion molecules, oncogenes, also pro/anti-apoptotic proteins. NFkB is a ubiquitously expressed eukaryotic transcription factor that is answerable for the regulation of numerous genes. Five subunits have determined for NFkB: p50 (NFkB1), p52 (NFkB2), p55 (RelB), p65 (RelA), and c-Rel (Rel). When NFkB is activated by inducements such as bacterial lipopolysaccharides (LPS) or pro-inflammatory cytokines, it displaces to the cell nucleus and starts the expression of a variety of target genes, such as Tumor
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