BIOC 3014 Coursework Kai et al IkB Kinase β (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor kB (NFkB) signalling. 2014, J Biol Chem 289(38)26960-72. http://www.ncbi.nlm.nih.gov/pubmed/?term=J+Biol+Chem+289(38)26960-72 Each question is marked out of 25%. The technique and detail parameter was subtracted from the paper directly used as a instruction and reference. 1. Discuss in detail the effects that an activating mutation in the IKBKB gene would be expected
In the spring of 1938, one of the deadliest pandemics first emerged along the shores of Italy. Through the examination of historical documents regarding this pandemic, it was discovered that the Black Death, or the plague, was initially spread among several Italian merchant ships on the return to the city of Messina from different regions of Asia, and such a sickness was a mystery to the sailors, as well as to the citizens, whom have succumbed to it (“The Black Death”). After a period of three years
6 weeks. Oxidative stress was determined by analyzing blood for reactive oxygen species (ROS) generation. Inflammatory state was determined by assessing nuclear NFKB DNA binding activity (via gel shift assay) and TNFα mRNA expression (via PCR testing). Resveratrol supplementation was found to significantly reduce ROS generation, NFKB DNA binding activity, and TNFα mRNA expression compared to both baseline and the placebo group at 3 and 6 weeks. (see figure 1). The authors therefore concluded that
Cellular Basis Of Disease: Why has the discovery of Toll-like receptors revolutionised our understanding of how the innate immune system works, and what is the therapeutic potential? The body has two immune systems: the innate immune system and the adaptive immune system. Adaptive, or acquired, immunity refers to antigen-specific defence mechanisms that take several days to become protective and are designed to react with and remove a specific antigen. This is immunity develops throughout life.