Yin Yang 1 in HCC: YY1 is a transcription factor with complex biological functions, including apoptosis, tumorigenesis, development and differentiationYY1 is a member of the Polycomb Group protein family, a group of homeobox gene receptors that play critical roles in hematopoiesis and cell cycle control [26, 27]. The human YY1 gene is located on the telomere region of human chromosome 14 at the segment q32.2. It consists of five highly conserved exons encoding a protein of 14 amino acids in length, and an estimated molecular weight of 44 kDa. The YY1 protein contains four C2H2-type zinc-finger motifs with two specific domains that characterize its function as an activator or repressor. YY1 is a phosphoprotein with a half-life of 3.5 hours. …show more content…
The function of YY1 in transcription is context-specific and requires interactions with many cellular factors. As a result, YY1 develops intracellular networks that allow it to induce multiple functions in transcriptional initiation, activation and repression, ultimately leading to the regulation of normal cell growth and survival. As a DNA binding protein, YY1 functions in the replication and regulation of the histone alpha complex, vital for proliferating cells[29].Overexpression of YY1 in tumor tissues exerts different clinical behavior in different tumor types. YY1 The loss of YY1 results in a significant increase in p53 levels. YY1, MDM-2 and p53 can form a ternary complex and YY1 is essential for optimal MDM2-p53 physical interactions in vivo, which is a prerequisite for MDM2 to be able to ubiquinate p53. Ubiquitination induces the translocation of p53 to the proteasome which leads to its …show more content…
A large body of literature has documented hyperactivated AKT signaling in human solid tumors and hematological malignancies[34]. The PI3K/AKT/mTOR signaling pathway plays an important role in HCC and is activated in 30%–50% of HCC[35]. Sorafenib does not target this pathway. AKT/mTOR is critical for regulating growth and proliferation in any cell type. Data from HCC clinical trials have revealed that AKT/mTOR pathway is upregulated upon treatment and therefore the cancer acquires resistance to therapy. Cyclin D1 is a downstream target of AKT, which directly regulates cell cycle progression. Of the three highly conserved AKT isoforms, AKT1 is involved in regulating cell proliferation[36]. Accumulating research suggests that PI3K/AKT activation after sorafenib treatment plays a pivotal role in tumor progression in HCC. p-AKT levels increase in HCC cell lines after treating them with sorafenib [11, 37]. Targeting AKT1 will also suppress the activity of its downstream effector pathway
How I join the Army National Guard, was kind of crazy My friend name Rico campbell had told me he was about to join the Army National Guard and they were offering a $20,000 sign on bonus. I stated “do you know what we can do with all that money”. We Both went to a recruiter Name SFC (Sergeant First Class ) Tim Thomas he said “ what do you want out of life” both of us promptly replied “ I don't know”. I join The National guard that day but my Friend Rico nevered joined. After I join and Sign all the necessary paperwork SFC Thomas said “You are going to Iqra in may !”. At that time my heart dropped out of my body.
A little under two years ago, one day after basketball practice, I received a call from an unknown number. It was a 512 area code, and I was curious to see who it was. I answered the phone– it was the regional president at the time, Barrett Dover, inviting me to join BBYO Lonestar Region. Even though I didn’t know Barrett that well, or know much about BBYO at all, this call was what led me to join. This personal call went a long way; for I would not be here today if it weren’t for Barrett and the 92 years of Alephs before me who have invited others to join BBYO.
I love to tell stories about my childhood. Looking back now, through all of my life’s experiences, it almost feels like I was living in a fairy tale. It brings both joy and sadness to my heart when I share these memories with my daughter. The joy comes from remembering how things were back then and how those things impacted my life today. The sadness comes from knowing that she will never get to experience those things, therefore, she will only get to live them through me. Even now as a young woman, she will say to me from time to time, “mom, tell me a story about the Good Ole Days”!
However with a recent act passed by the government maybe it doesn’t go far enough in preventing businesses and its practices from protecting consumers. But with implementation, it’s the ensurance of what businesses ultimately do o in the best interests of the American people.
Like many cancers it is triggered by mutations in the p53 protein gene and tends to spread quickly through the lymphatic system if not destroyed. Treatment most involves surgical removal in early stages and immunological treatment at latter stages.
Every single day I have to ride my bicycle throughout the city of Miami. The perks I would say is that it is safer for the environment by causing less pollution in the air and I get a good cardio workout every day. The negative outcome of not having a car however is that I almost get hit or what feels like killed every other hour on the street. But how the person perceives this situation is really what is at hand. I take the time every once in a while and stop near a park or by a lake and just admire nature in its vast beauty and how truly wonderful it is to be alive, most people do not see how much of a blessing it is to just wake up every single day and being healthy. Having to worry about the weather is another issue that I have to be constantly worrying about, but thankfully at the end of the day it is just a little rain, unless it is a tremendous storm which dramatically increases my chance of being killed while riding my bike.
There's nothing worse than reflecting on something you once had, something that you loved, and realising that you will never be able to have it again. For me, it's the seasons I lived through in my childhood: every season had something to correlate to it. They always had something significant that made you know that that time of year was coming. But now it feels as if the seasons seem to float by me. That, or they are only signified because I've identified something I do not enjoy.
Have you ever felt like everything is going smoothly and you think that it’s going to be the best day ever and nothing’s going to go wrong and then BAM!!! Your life completely changed. This horrible circumstance happened to me on January 24th 2011 04:00.
The Yik Yak terms of services clearly stated that the app is not meant for people who are under 18 years of age. I believe that the reason why you need to be 18+ years old to use this app is because many underage people out there tend to bully someone or post threats. Many people can actually bypass this term by giving Yik Yak false information, but Yik Yak has geofencing system that can block students from certain schools from using the app. Yik Yak seems to do this because many underage students out there has been using Yik Yak for negative purpose, such as bullying other students or even posting threats to attack the school.
The day we left in 1-09-2056 it was not that good of a day. We were delayed 12 hours because of one of the batteries losing power when the ship was not on. My girlfriend did not want me to go after that but we needed the money and we would get to come back in 4 years and then we would leave again. We would be gone for a total of 12 years. I would go with two more people Bob, Joe, and me. This would be the first flight all through our galaxy.
People tend to use food as an escape route from feelings, to-do lists, or problems. Each emotion we have has its own trigger, and each has its own solution. Food does not fix problems or feelings, but instead, is a temporary distraction.
Mutations (for most cancers) must appear in both tumour suppressing genes and oncogenes for cancers to form. The tumour suppressing genes and oncogenes act in complementary fashion to one another; one pulls forward, and the other pushes back ensuring that the cell cycle occurs in a controlled manner (Sherr, 2004).
In this young, fragile stage of our young ones lives, they tend to copy what they see and what they hear. It is essential for them to be in a positive environment where they can learn the difference between right and wrong. They are developing their fragile minds and are starting to learn what is what. This is why we have decided to expand. These children deserve the utmost best and we tend on doing this.
In a normal cell, the rate at which the normal cell grows and proliferate is tightly regulated, however, resistance to such regulation as a result of gene mutation is a hallmark of cancer. Proto-oncogenes, tumor suppressor genes, and microRNA genes are the three major groups of normal cellular genes associated with cancer(Faguet, 2015).
Histones are proteins that are found in the nucleus of the Eukaryotic cells. Histone proteins function is to condense and package DNA in units called nucleosome. There are four core histones known as H2A, H2B, H3, and H4. Core histones can be paired up with each other to form H2A-H2B dimers and two copies of each H3 and H4 histones can paired up to form a H3-H4 tetramer. The histone octamer is form when a H3-H4 tetramer is combined with 2 H2A-H2B dimers.