1-Chloro-4-isopropylcyclohexane exists as two stereoisomers: one cis and one trans. Treatment of either isomer with sodium ethoxide in ethanol gives 4-isopropylcyclohexene by an E2 reaction. CH,CH,O Na* CI CH,CH,OH 1-Chloro-4- 4-Isopropylcyclohexene isopropylcyclohexane The cis isomer undergoes E2 reaction several orders of magnitude faster than the trans isomer. How do you account for this experimental observation?
1-Chloro-4-isopropylcyclohexane exists as two stereoisomers: one cis and one trans. Treatment of either isomer with sodium ethoxide in ethanol gives 4-isopropylcyclohexene by an E2 reaction. CH,CH,O Na* CI CH,CH,OH 1-Chloro-4- 4-Isopropylcyclohexene isopropylcyclohexane The cis isomer undergoes E2 reaction several orders of magnitude faster than the trans isomer. How do you account for this experimental observation?
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter9: Nucleophilic Substitution And Β-elimination
Section9.7: Experimental Evidence For E1 And E2 Mechanisms
Problem 9.7P
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