1) What happens to the RMP as the extracellular K* is increased? In other words, does RMP become more positive, more negative, or does it stay the same? 2) What generates the gradients for Na* and K* in a living cell? 3) What could happen to neurons (and muscle cells) of someone that was injected with a high dose of KCI?

Principles Of Pharmacology Med Assist
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ISBN:9781337512442
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Chapter27: Medications That Affect The Nervous System
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Lab 2.1 - Prelab
PhysioEx Ex. 3, Activities 1 and 3
Before coming to class, complete PhysioEx: Exercise 3 (Nerve Impulses in Single Neurons) Activities 1 and 3. Note that
you do not need to print or turn in your completed PhyisoEx activities. Instead, you should answer the questions below
and turn in these questions as your pre-lab for lab 2.1.
Activity 1: Resting Membrane Potential (RMP).
The axon membrane contains two kinds of Na* and K* channels. Leak channels are always open to allow a slight influx of
Na+ and larger efflux of K*. This helps generate the resting membrane potential (RMP). These simulations demonstrate
how relative concentrations of Na* and K* inside and outside the neuron affect RMP as they diffuse down their
gradients. Follow the procedures in PhysioEx Ex. 3 Activity 1 and use your data from Chart 1 to answer the questions
below:
1) What happens to the RMP as the extracellular K* is increased? In other words, does RMP become more positive,
more negative, or does it stay the same?
2) What generates the gradients for Na* and K* in a living cell?
3) What could happen to neurons (and muscle cells) of someone that was injected with a high dose of KCI?
4) If Na' channels were suddenly opened in a resting neuron, what would happen to the membrane potential?
Skip Activity 2.
Activity 3: Action Potentail Threshold
1)
Follow procedure in PhysioEx Ex. 3 Activity 3 and use your data from Chart 3 to answer the questions below:
2)
What was the threshold voltage to generate an action potential (AP)?
3)
Did the amplitude (height) of the AP change as the stimulus was increased?
4)
State the law or rule that describes this property:
Transcribed Image Text:Lab 2.1 - Prelab PhysioEx Ex. 3, Activities 1 and 3 Before coming to class, complete PhysioEx: Exercise 3 (Nerve Impulses in Single Neurons) Activities 1 and 3. Note that you do not need to print or turn in your completed PhyisoEx activities. Instead, you should answer the questions below and turn in these questions as your pre-lab for lab 2.1. Activity 1: Resting Membrane Potential (RMP). The axon membrane contains two kinds of Na* and K* channels. Leak channels are always open to allow a slight influx of Na+ and larger efflux of K*. This helps generate the resting membrane potential (RMP). These simulations demonstrate how relative concentrations of Na* and K* inside and outside the neuron affect RMP as they diffuse down their gradients. Follow the procedures in PhysioEx Ex. 3 Activity 1 and use your data from Chart 1 to answer the questions below: 1) What happens to the RMP as the extracellular K* is increased? In other words, does RMP become more positive, more negative, or does it stay the same? 2) What generates the gradients for Na* and K* in a living cell? 3) What could happen to neurons (and muscle cells) of someone that was injected with a high dose of KCI? 4) If Na' channels were suddenly opened in a resting neuron, what would happen to the membrane potential? Skip Activity 2. Activity 3: Action Potentail Threshold 1) Follow procedure in PhysioEx Ex. 3 Activity 3 and use your data from Chart 3 to answer the questions below: 2) What was the threshold voltage to generate an action potential (AP)? 3) Did the amplitude (height) of the AP change as the stimulus was increased? 4) State the law or rule that describes this property:
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