1. A woman with blood type O was rushed to the hospital after an accident. She needed a blood transfusion. Her family wanted to donate but no one was a match. Her partner was a man with blood type A and they had two children, a boy with blood type AB and a girl with blood type B. The woman's mother has blood type A and the woman's father has blood type AB. (You can assume both the daughter and son are the biological children of both parents, and the woman is the biological son of her parents.) a. Explain why these results cannot be illustrated by the simple inheritance of the ABO blood type. b. The expression of ABO antigens depends on alleles at the H locus. A dominant allele ( H) at the H locus encodes an enzyme that makes compound H, which is needed for the production of ABO antigen. The recessive allele ( h) encodes a defective enzyme that is incapable of making compound H. Based on this information and the ABO phenotypes, determine the ABO and H genotypes for each of the six members of this extended family. Use "?" for any alleles that cannot be determined. c. Of the two loci for ABO and H, which is epistatic and what type of epistasis occurs?

1. A woman with blood type O was rushed to the hospital after an accident. She needed a blood transfusion. Her family wanted to donate but no one was a match. Her partner was a man with blood type A and they had two children, a boy with blood type AB and a girl with blood type B. The woman's mother has blood type A and the woman's father has blood type AB. (You can assume both the daughter and son are the biological children of both parents, and the woman is the biological son of her parents.) a. Explain why these results cannot be illustrated by the simple inheritance of the ABO blood type. b. The expression of ABO antigens depends on alleles at the H locus. A dominant allele ( H) at the H locus encodes an enzyme that makes compound H, which is needed for the production of ABO antigen. The recessive allele ( h) encodes a defective enzyme that is incapable of making compound H. Based on this information and the ABO phenotypes, determine the ABO and H genotypes for each of the six members of this extended family. Use "?" for any alleles that cannot be determined. c. Of the two loci for ABO and H, which is epistatic and what type of epistasis occurs?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 14QP

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