1. Aromatic compounds are metabolized via transformation of the aromatic ring to a reactive metabolite, arene oxide. Suggest two possible reactions of this metabolite and provide the products of those reactions ? P450 aromatic arene ? compound oxide

1. Aromatic compounds are metabolized via transformation of the aromatic ring to a reactive metabolite, arene oxide. Suggest two possible reactions of this metabolite and provide the products of those reactions ? P450 aromatic arene ? compound oxide

General, Organic, and Biological Chemistry

7th Edition

ISBN:9781285853918

Author:H. Stephen Stoker

Publisher:H. Stephen Stoker

Chapter14: Alcohols, Phenols And Ethers

Section: Chapter Questions

Problem 14.71EP: Three isomeric pentanols with unbranched carbon chains exist. Which of these isomers, upon...

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Concept explainers

Aromatic Compounds

Aromatic organic compound or aromatic system is an important class of hydrocarbons under the branch of organic chemistry. Aromatic compounds are also called arenas. The definition of aromatic organic compounds can be stated as a class of organic compounds with a planar cyclic ring of atoms bonded through alternated single and double bonds. Due to these alternating bonds, a peculiar feature termed as ‘resonance’, that is, delocalization of pi electrons or the electrons is shared within the atoms of the ring which are present in the aromatic compounds. The word ‘aromatic’ includes a Greek word ‘aroma’ which means smell, indicating that they were named as such due to the sweet odor they produce. Many well-known flavors such as vanilla, cinnamon, and few scents from flowers are extracted from aromatic compounds. Benzene with chemical formula C6H6 is a very common aromatic compound that contains six atoms of carbon held in the cyclic ring of alternate double bonds. It is also to be noted that not all aromatic compounds contain benzene ring. This can be explained by Huckel’s rule.

Question

1. Aromatic compounds are metabolized via transformation of the aromatic ring to a
reactive metabolite, arene oxide. Suggest two possible reactions of this metabolite and
provide the products of those reactions
?
P450
aromatic
arene
?
compound
oxide
?

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