1. Purine synthesis begins with the synthesis of IMP. Beginning with IMP, write the step(s) involved in its conversion to AMP, including the names and structures of all reactants and products.
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- 1) How is the TCA cycle regulated? a) Draw the TCA diagram that fills in all possible regulation points.Is there anyway to draw a visual diagram for this as the explanation does not make sense how can 2 aspartates interact with each other under physiological pH?Rapamycin has been shown to reduce adiposity in mice, at least in the short term. Why then have we not seen rapamycin on the shelves at our local pharmacy?
- Provide a diagram of the EPH RECEPTOR B2 (EPHB2) structure. Give annotations of binding sites and enzyme active sites.In humans the purine ring cannot be degraded. How is itexcreted? What reactions are involved?If D-glyceraldehyde-3-phosphate (DGAP) is dissolved in water, 96% of it will form dihydroxy- acetonephosphate (DHAP). Which of the following will triose phosphate isomerase do? a)Shift the balance to 100% DHAP b)Shift the balance to 0% DHAP c)Catalyze the peptide bond breaking d)Make the reaction faster
- If D-glyceraldehyde-3-phosphate (DGAP) is dissolved in water, 96% of it will form dihydroxy- acetonephosphate (DHAP). Which of the following will triose phosphate isomerase do? a)Shift the balance to 100% DHAP b)Shift the balance to 0% DHAP c)Shift the balance to 50 DGAP : 50 DHAP d)Catalyze the peptide bond breaking e)Make the reaction fasterThe NMDA receptor I/V curve is nonlinear, why? What about the GluA2-containing AMPA receptor I/V curve? Draw both under normal physiological conditions. In addition, explain what happens for the NMDA receptor I/V curve when you lower the magnesium concentration.43. Sequentially list the signal transduction process from ligand binding to biological response for the phospholipase C system. You may use the appropriate abbreviations in your list.
- The metabolic precursor for the production of most eicosanoids isConsider the synthesis and degradation of tyrosine as shown in Figures 25.37, 25.38, and 25.48 to determine where the carbon atoms in PEP and erythrose-4-P would end up in acetoacetate and fumarate.Chymotrypsin preferentially binds the transition state. What is meant by that?