1. Why do individualized dosing regimens need to be determined for some patients? (1) 2. What is the major difference between absolute bioavailability and relative bioavailability? (2) 3. Discuss (outline and give the implications) two characteristics of a drug that predict its transport across cell membranes. (2) 4. Illustrate and briefly describe four types of mammillary models. (4)

1. Why do individualized dosing regimens need to be determined for some patients? (1) 2. What is the major difference between absolute bioavailability and relative bioavailability? (2) 3. Discuss (outline and give the implications) two characteristics of a drug that predict its transport across cell membranes. (2) 4. Illustrate and briefly describe four types of mammillary models. (4)