18-year-old Gabrielle checks her calendar. It has been 42 days since her last menstrual period, two weeks later than the length of the average woman’s menstrual cycle. Although many women would suspect pregnancy if their period was late, Gabrielle has not been sexually active. She is not
18-year-old Gabrielle checks her calendar. It has been 42 days since her last menstrual period, two weeks later than the length of the average woman’s menstrual cycle. Although many women would suspect pregnancy if their period was late, Gabrielle has not been sexually active. She is not even sure she is “late” because her period has never been regular. Ever since her first period at 13 years of age, her cycle lengths have varied greatly, and there are months where she does not get a period at all. Her mother told her that a girl’s period is often irregular when it first starts, but Gabrielle’s still has not become regular five years later. She decides to go to the student health center on her college campus to get it checked out.
The doctor asks her about the timing of her menstrual periods and performs a pelvic exam. She also notices that Gabrielle is overweight, has acne, and excess facial hair. As she explains to Gabrielle, while these physical characteristics can be perfectly normal, in combination with an irregular period they can be signs of a disorder of the endocrine, or hormonal, system called polycystic ovary syndrome (PCOS).
In order to check for PCOS, the doctor refers Gabrielle for a pelvic ultrasound and sends her to the lab to get blood work done. When her lab results come back, Gabrielle learns that her levels of androgens (a group of hormones) are high, and so is her blood glucose (sugar). The ultrasound showed that she has multiple fluid-filled sacs known as cysts in her ovaries. Based on Gabrielle’s symptoms and test results, the doctor tells her that she does indeed have PCOS. PCOS is common in young women. It is estimated that between 1 in 10 to 20 women of childbearing age have PCOS — as many as five million women in the United States. You may know someone with PCOS or may have it yourself.
1. Why can hormones have such a broad-range effect on the body, such as is seen in PCOS?
2. Which hormones normally regulate blood glucose and how is this related to diabetes?
3. What are androgens? How do you think their functions relate to some of the symptoms that Gabrielle is experiencing?
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