2. Roughly sketch the hydropathy plot for the given hypothetical membrane protein. Follow the color assignments of the helical domains and properly label your plot and axes (NB: Only a rough sketch is being asked. No need be exact with the hydropathy indices and residue numbers).

2. Roughly sketch the hydropathy plot for the given hypothetical membrane protein. Follow the color assignments of the helical domains and properly label your plot and axes (NB: Only a rough sketch is being asked. No need be exact with the hydropathy indices and residue numbers).

Anatomy & Physiology

1st Edition

ISBN:9781938168130

Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Chapter3: The Cellular Level Of Organization

Section: Chapter Questions

Problem 6RQ: Because they are embedded within the membrane, ion channels are examples of ________. receptor...

See similar textbooks

Related questions

Q: Disulfide bridges are limited in that only one particular amino acid can form these types of interac...

A: Amino acids are building blocks of proteins and alpha carbon of amino acids consist of carboxylic gr...

Q: What is the difference between the two salt precipitation methods: salting in and salting out? Gro...

A: SAlting out is a method generally used in purification of molecules depending on their solubility a...

Q: Why is the resulting disease-COVID 19-cause respiratory distress and/or intestinal distress?

A: People who are experiencing problems breathing, typically exhibit indicators of respiratory distress...

Q: Think of and identify a modern-day problem that can be solved by Genetic Engineering. If you were a ...

A: Genetic engineering is a branch of science which involves recombinant DNA technology to introduce fo...

Q: Cecilia is a l45-pound woman who consumes five standard drinks (14 gr of alcohol each). Estimate how...

A: Widmark Formula: This is a formula suggested by Swedish Scientist and forensic toxicologist Erik Wid...

Q: Three proteins K, L and M have the same % composition. Which is TRUE? A. The three proteins will ha...

A: Proteins are composed of a linear chain of amino acid sequences attached together via peptide bonds....

Q: What changes in the structure of each polysaccharide affect its gelling property? Explain

A: Colloid polysaccharides, proteins, and synthetic polymers are used to make gels, which are solid, je...

Q: Modified true or false. Write the correct answer if the underlined word is false. 1. A prosthetic g...

A: Proteins' principal role is to act as enzymes—catalysts that help cells speed up nearly all chemical...

Q: 3. Show a biological mechanism for the following retro process from the glyoxalate cycle. co.o OH

Q: drofofo %3D P-o-P-o- 6- o- o-P-o-P-o- -오-오 O oxidoreductase O isomerase O lyase O hydrolase O ligase...

A: The enzymes are classified into six different groups based on the reaction it catalyzes. The differe...

Q: From natural to synthetic ingredients in perfumery Explain and give example

A: When we smell perfume, we recognise certain fragrances. Scents of flowers, fruits, some foods, leath...

Q: What is measured at the A280 absorbance values?

A: Proteins in solution has a absorbance maxima at 280. The aromatic amino acids are responsible for th...

Q: Given a tripeptide Cys-His-Lys, Cys: Pk: = 1.71; Pk2= 10.78; Pke= 8.33 His: Pk = 1.82; Pkz= 9.17; Pk...

A: Proteins are composed of amino acids, which are bound together by peptide linkage. Amino acids conta...

Q: List the ketone bodies. Where are they synthesized and where are they used?

A: Ketone bodies have a distinct odour that can be detected in the breath of people in ketosis or ketoa...

Q: Increase the amount of substrate present. Increase the amount of enzyme present. Decreas...

Q: prepare 0.7% potassium Chloride (KCI) in 0.3 liter? * 0.21 gm O 21 gm O 210 gm 0.021 gm

A: Diluting or mixing two or more substances or even compounds refer as 'Dilution'. The ratio of...

Q: What is meant by reciprocal regulation ? Name one compound that reciprocally regulates glycolysis an...

Q: What amino acids are present on the unknown sample based on the results below? Test

A: Ninhydrin Test is used to test the presence of ammonia, amines or alpha amino acids or primary amine...

Q: 11.With the help of the buffer reaction in our body explain in a few sentences how the body fights m...

A: Introduction: pH regulation is a function of buffer systems of the body in combination with the resp...

Q: What happens when cell division didn’t undergo or complete the Meiosis I and Meiosis II?

A: A process by which cell divide into two or more daughter cells and distributes its genetic material ...

Q: Why are carbohydrates the body's preferred source of energy? Because they ... * A. are expensive t...

A: Carbohydrates considered as sugar molecules. Along with other proteins and fats, carbohydrates are a...

Q: 47. Protein Sequencing Applies changes in pH to separate amino acids Applies changes in pH to sepa...

A: "Since you have posted a multiple question, we will answer the first question for you. If you want a...

Q: Discuss the chemistry and occurrence of naturally occurring peptides.

A: Amino acids are organic molecules having an amino group and an acid group. Amino acids ar...

Q: In a haploid, a nonsense suppressor su1 acts on mutation1 but not on mutation 2 or 3 of gene P. An u...

A: In a procedure known as synthetic rescue, a suppressor mutation is a second mutation that alleviates...

Q: Polysaccharides are * A. saccharide unit that contains 3 to 10 units B. the simplest sugar uni...

A: Carbohydrates are a key source of food and a source of energy for the majority of living organisms. ...

Q: What is An enzyme that denatures PROTEIN?

A: The change of shape of a protein by external action, which may or may not change the amino acid sequ...

Q: List the systematic classification of enzymes according to the Enzyme Commission indicating the clas...

A: A protein or RNA produced by living cells that is highly selective and catalytic to its substrates i...

Q: In general, proteins can be classified into 3 different groups. Name and give a short description of...

A: In practically all cells, proteins are the essential substance. They make up around a quarter of a c...

Q: The enzyme that removes the RNA primer from the Okazaki fragment is: DNA pol III DNA ligase ...

A: Introduction: DNA is the hereditary material that defines every cell. It is found within the nucleus...

Q: A. Which of the following molecules in not a reasonable intermediate in the conversion of oxaloaceta...

A: Q. A. Asparagine is the amide of aspartic acid. Oxaloacetate is asparagine's precursor. Oxaloacetate...

Q: A mixture containing arginine, glutamic acid and isoleucine was subjected to electrophoresis at pH 7...

A: Amino acids differ from each other on the basis of their side-chain properties. There are twenty sta...

Q: Which mixture acts as buffer solutions? O 50 ml 0.1M H2CO3 and 100 ml 0.1M NAOH 100 ml 0.1M H2CO3 an...

A: A buffer solution is composed of a weak acid and its conjugate base. The buffer solution resists the...

Q: The figure shows that the average distance between base pairs measured parallel to the axis of a DNA...

A: DNA is composed of 2 polynucleotide strands would in a helical manner. Distance between 2 base pairs...

Q: Amount of water added (mL) Amount of Stock Solution (mL) Final Concentration A Solution 1 0. Solutio...

A: The concentration of unknown solution can be calculated from the formula C1V1= C2V2 Where C1= Concen...

Q: An unknown sample was tested if there is a presence of lipid, after the test it shows that it produc...

A: Acrolein test is commonly used to detect the presence of lipids in a sample. The sample is treated w...

Q: Assigned Member of the Group of Alcohol Dehydrogenase and Lysozyme

A: Alcohol dehydrogenase is an enzyme that catalyses the conversion of ethanol to acetaldehyde. CH3-CH2...

Q: Give the similarities and differences of the gel filtration and isoelectric precipitation in terms o...

A: Protein Purification: Modern protein science lab and related industries overexpress target protein i...

Q: The steady-state kinetics of an enzyme has been studied in the absence and presence of an inhibitor ...

A: To study the steady state enzyme kinetics, often enzyme velocity “V” is determined at various substr...

Q: In order to replicate both strands of DNA SIMULTANEOUSLY , E. coli bacteria folds or loops one stran...

A: Replication is the process by which new strands are synthesized complimentary to their parent strand...

Q: Why does this step in particular proceed spontaneously under typical cellular conditions?

A: Glycolysis is defined as a series of enzymatic reactions that convert one molecule of glucose, a six...

Q: In Chapter 3, the Kd of calmodulin EF hands for binding Ca2+ is given as 10−6 M. Many proteins have ...

A: Calmodulin is a Ca2+ sensor with EF-hands as its high-affinity Ca2+ binding domains, making it a pro...

Q: Name the four different types of interactions responsible for creating tertiary structures in protei...

A: Tertiary structures shape is determined via the different bonding interactions between side chains o...

Q: what are the key glycolytic enzymes and why are they considered key? how are these steps overcome in...

Q: Why is the peptide formation always presented/read from N-terminal to C-terminal?

A: Introduction: Amino acids are joined together by a condensation reaction between carboxylic and ami...

Q: When experiencing stress, the effects of the epinephrine circulating in the body will result in a. b...

A: Therapeutic Epinephrine is a synthetic version of the sympathomimetic amine epinephrine, which has v...

Q: F1 progeny then mates with a short, brown, pretty male. The table below shows the res Based on the d...

A: To determine the correct order of the gene,we need to compare the recombinant frequencies among all ...

Q: D-Galactose DGlucose CORRECT INCORRECT Glucose and galactose are both Aldohexoses They constitute th...

A: Glucose and galactose are biomolecules categorized under carbohydrates. Generally carbohydrates are ...

Q: Which of the following repair mechanisms would most likely be used to repair a G in DNA damaged by o...

A: Genetic variation is very important for evolution, but genetic stability is crucial for survival of...

Q: Select the two most hydrophobic amino acids. A. Leucine and Isoleucine OB. Arginine and Lysine OC Cy...

Q: Three polypeptides, the sequences of which are represented using the one-letter code for their amino...

A: Proteins are composed of amino acids, which are bound together by peptide linkage. Amino acids conta...

Question

Answer the given question Clearly and Graph it neatly

2. Roughly sketch the hydropathy plot for the given hypothetical membrane protein. Follow the color
assignments of the helical domains and properly label your plot and axes (NB: Only a rough sketch is
being asked. No need be exact with the hydropathy indices and residue numbers).

Hydropathy Plots
10
50
100
150
200
250
3
↑
Hydrophobic
Hydrophilic
Amino
terminus
Outside
-3
10
50
100
150
200
250
Residue number
Bacteriorhodopsin
Inside
Carboxyl
terminus
Hydropathy index

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Step 3

VIEW

Step by step

Solved in 3 steps with 3 images

SEE SOLUTION Check out a sample Q&A here

Similar questions

1. In Gel filtration chromatography, when will you stop collecting eluents if sample is not colored? 2. How does SDS-PAGE separate proteins and peptides from each other? Explain. 3. Explain the Donnan Membrane Phenomenon. Why is it important for the homeostasis of the cell?
1. Researchers have discovered a new membrane protein that has three transmembrane domain αhelixes that span the lipid bilayer. a. If the lipid bilayer is 30 Å thick, what is the smallest number of amino acid residues that can be in each α-helixes for them to be long enough to span the bilayer? b. If one of the three α-helixes is titled at a 32° angle relative to an axis perpendicular to the surface of the lipid bilayer, what is the smaller number of amino acid helixes required for that helix to still span the lipid bilayer? c. How many hydrogen bonding interactions would there be in the smallest possible tilted transmembrane α-helix? d. If the tilted α-helix was a 310 helix instead how many amino acid residues would be required to span the lipid bilayer? How many amino acid residues would be required if it was a π-helix?
1. Working as an engineer in the R&D section of a biotech industry, you are asked to select a membrane to concentrate a solution containing a protein with a molecular weight of 200 kDa; Fortunately, it has three types of membrane in the cellar: one for MF, one for UF and one for RO. Which one would you choose to perform the required service? Could you establish some characteristics of the chosen membrane?
Hydropathy plot analysis of your protein of interest reveals a single, prominent hydrophobic peak. However, you later discover that this protein is soluble and not membrane associated. Explain how the hydropathy plot may have been misleading.
2. Unlike soluble, cytosolic proteins, transmembrane proteins are more difficult to purify, Which of the following substances is most used to help purify a transmembrane protein? a. high salt solution b. sucrose c. detergent d. ethanol e. glucose
2. Would you expect an instrinsically disordered protein to contain a higher proportion of hydrophilic or hydrophobic residues? Explain your reasoning.
6. A carrot, when dried out, becomes soft. There is a way to make it firm and crisp. Explain how and why, using the following guidelines. a) Draw and label a representative cell of the carrot, in its dried state. Be precise in your drawing. b)Describe the type of extracellular solution that is appropriate to add to make the desired change (name and define what type of solution, the net movements of solvent and solutes, etc.). c)Draw a representative cell of the carrot, in its possible state after the change. Represent the movement of water using an arrow to indicate what has happened.
1. Discuss how the pH and temperature affect the solubility of protein. 2. Explain "salting-in" in your own words.
1. Consider the following α helix from myoglobin at pH 7. Gln-Gly-Ala-Met-Asn-Lys-Ala-Leu-Glu-His-Phe-Arg-Lys-Asp-Ile-Ala-Ala-Lys-Tyr(a) Label amino acids in the polypeptide above as follows: p for polar and uncharged, np for non polar, – for negatively charged, and + for positively charged.(b) How many complete turns are there in this helix?(b) Which side chains are likely to be on the side of the helix that faces the aqueous solvent? Why?(c) Which side chains are likely to face the interior of the protein? Why?
Researchers have discovered a new membrane protein that has three transmembrane domain αhelixes that span the lipid bilayer.a. If the lipid bilayer is 30 Å thick, what is the smallest number of amino acid residues thatcan be in each α-helixes for them to be long enough to span the bilayer?
17. The transition temperature of a membrane bilayer is determined directly or indirectly a. the ability of lipid molecules to be packed together b. whether the fatty acid chains of the lipids are saturated or unsaturated c. the extent to which the fatty acid chains of the lipids contain double bonds d. the length of the fatty acid chains. e. All of the above are correct answers.
1a-Membrane bound proteins often contain transmembrane domains. These transmembrane domains contain higher amounts of which of the following. Select all that apply. Select one or more: a. Non polar amino acids b. Polar amino acids c.Polar charged amino acids d. Amino acids with hydrophillic residues (R groups) 1b-In most cases, the major function of protein kinases is to: Select one: Oa.Add phosphate groups to certain proteins O b. Hydrolyze GTP to GDP O c. Add CAMP to adenylyl cyclase O d. Facilitate binding of signalling molecules to the associated membrane bound receptor.